2014
DOI: 10.1039/c4ay00248b
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Stability-indicating thin-layer chromatographic method for determination of darunavir in complex darunavir–β-cyclodextrin in the presence of its degradation products

Abstract: A method was developed to identify degradation products of the complex darunavir–β-cyclodextrin.

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Cited by 9 publications
(3 citation statements)
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“…Method by Thin Layer Chromatography (TLC) and High-Performance Liquid Chromatography (HPLC) were developed for the identification and quantification of darunavir in the darunavir: β-cyclodextrin complex [20,21]. These methods were also able to identify degradation products of the complex, being considered methods indicative of stability.…”
Section: Methodsmentioning
confidence: 99%
“…Method by Thin Layer Chromatography (TLC) and High-Performance Liquid Chromatography (HPLC) were developed for the identification and quantification of darunavir in the darunavir: β-cyclodextrin complex [20,21]. These methods were also able to identify degradation products of the complex, being considered methods indicative of stability.…”
Section: Methodsmentioning
confidence: 99%
“…A simple HPLC method has been developed for the determination of 4-amino-N-(2-methyl propyl)benzene sulphonamide impurity from bulk darunavir [23], another selective RP-HPLC method was developed for the separation and quantification of darunavir from its process related substances [24]. A simple, selective and inexpensive stability-indicating thinlayer chromatographic (TLC) method was developed for the determination of darunavir in presence of darunavir-β-cyclodextrin complex and its degradation products [25]. Unfortunately, high detection levels and low separation efficiency are the disadvantages of reported HPLC methods.…”
Section: Introductionmentioning
confidence: 99%
“…The official specification for the doxycycline hyclate present in dosage form is from 95.0% to 105.0% [6]. However, HPLC demands expensive equipment and columns, organic solvents in the preparation of solutions and/or mobile phases and the analysis time is longer than the carried out on Infrared spectroscopy or Ultraviolet spectrophotometric or Thin layer chromatography [13], which generates a greater time spent by analysts in performing the test and the lower logistics of equipment usage [1].…”
Section: Introductionmentioning
confidence: 99%