Stability-Indicating Liquid Chromatographic Determination of Etoposide and Benzyl Alcohol in Injectable Formulations

Floor, B.; Klein, A. E.; Muhammad, Naseem; Ross, Daniel L.

doi:10.1002/jps.2600740219

Cited by 21 publications

(4 citation statements)

References 6 publications

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“…In addition, in the clinical use of these drugs for the control and cure of cancer, etoposide and teniposide, which are well known for its anti-tumor activity and related to the podophyllotoxin, are enzymatically degraded to podophyllotoxin with toxic side effects [14]. It is obvious that podophyllotoxin exists commonly around us.…”

Section: Introductionmentioning

confidence: 99%

Development of an enzyme-linked immunosorbent assay for podophyllotoxin

Liu

et al. 2005

International Immunopharmacology

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Section: Introductionmentioning

confidence: 99%

Development of an enzyme-linked immunosorbent assay for podophyllotoxin

Liu

et al. 2005

International Immunopharmacology

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“…Patients who undergo MRI-based arthrography for standard clinical indications are commonly administered a contrast agent like gadolinium diluted in bacteriostatic saline (Link2) [14]. Few chromatographic methods have been reported also for determination of BZA in combination with other drugs [15][16][17][18]. To the best of our knowledge, this is the first paper dealing with stability indicating chromatographic separation of TAM and BZA despite they are formulated in a vial form.…”

Section: Introductionmentioning

confidence: 99%

Stability Indicating HPLC Method for the Simultaneous Estimation of Triamcinolone Acetonide and Benzyl Alcohol in Pure Form and Epirelefan® Vial

Sebaiy¹,

El-Adl²,

Baraka³

et al. 2021

AJMC

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A rapid, sensitive, and accurate stability indicating HPLC method was developed for the simultaneous determination of triamcinolone acetonide and benzyl alcohol in pure form, degradation products and pharmaceutical preparation. The separation was carried out on RP BDS Hypersil® C18 column (150 x 4.60 mm, 5μm) using an isocratic mobile phase composed of acetonitrile: 0.05 M phosphate buffer PH 3.50 (55 : 45). Both benzyl alcohol and triamcinolone acetonide quickly eluted at 1.67 min and 3.42 min, respectively, with a flow rate of 1.50 mL /min and UV detection at 254 nm. The linearity was in the range of 1 – 50 µg/mL for triamcinolone acetonide and 2 - 10 µg/mL for benzyl alcohol. The method has been validated for linearity, accuracy, precision, specificity, limit of detection, limit of quantification, robustness, and ruggedness as per the ICH guidelines. Finally, the method was compared statistically with reference methods indicating that there is no significant difference between them in respect of precision and accuracy.

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“…In Iran, a warning was issued by the Ministry of Health to medical practitioners and hospitals that in a single year (2000) nearly 200 cases of paraplegia had resulted from the use of generic brands of Na-diclofenac injections. Several other gas 6,7 and liquid [8][9][10] chromatographic methods, as well as derivative UV spectrometry 11 and polarography, 12 have been employed for the identification and quantification of benzaldehyde. Recently, Rezaee and coworkers have developed a simple and rapid microextraction method, named dispersive liquid-liquid microextraction (DLLME), and so far it has been applied for the extraction of different compounds.…”

Section: Introductionmentioning

confidence: 99%