Stability Indicating HPLC Method for Simultaneous Quantification of Trihexyphenidyl Hydrochloride, Trifluoperazine Hydrochloride and Chlorpromazine Hydrochloride from Tablet Formulation

Shetti, Priya; Venkatachalam, A.

doi:10.1155/2010/529386

Cited by 10 publications

(7 citation statements)

References 28 publications

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“…Photolability of phenothiazine derivatives is a well-established fact—irradiation of chlorpromazine with UV-C (254 nm) and UV-A (365 nm) caused its significant loss (Prohotsky et al 2014 ); however, according to another study, after application of ICH-recommended overall illumination, only 4.5 % of the drug was degraded. In the case of trifluoperazine (the same study), degradation of 9.5 % of the substance was observed (Shetti and Venkatachalam 2010 ). Irradiation of trifluoperazine with sunlight and UV light yielded the formation of two phototransformation products (Subbareddy and Divakar 2016 ).…”

Section: Photostability Testing Of Drugsmentioning

confidence: 73%

Studies on photodegradation process of psychotropic drugs: a review

Trawiński

Skibiński

2016

Environ Sci Pollut Res

106

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Consumption of psychotropic drugs is still increasing, especially in high-income countries. One of the most crucial consequences of this fact is significant release of them to the environment. Considerable amounts of atypical antipsychotics, benzodiazepines, antidepressants, and their metabolites were detected in river, lake, and sea water, as well as in tissues of aquatic organisms. Their ecotoxicity was proved by numerous studies. It should be noticed that interaction between psychotropic pharmaceuticals and radiation may lead to formation of potentially more toxic intermediates. On the other hand, photo-assisted wastewater treatment methods can be used as an efficient way to eliminate them from the environment. Many methods based on photolysis and photocatalysis were proposed and developed recently; nevertheless, the problem is still unsolved. However, according to recent studies, photocatalysis could be considered as the most promising and far more effective than regular photolysis. An overview on photolytic as well as homogenous and heterogeneous photocatalytic degradation methods with the use of various catalysts is presented. The photostability and phototoxicity of pharmaceuticals were also discussed. Various analytical methods were used for the photodegradation research, and this issue was also compared and summarized. Use of high-resolution multistage mass spectrometry (Q-TOF, ion trap, Orbitrap) was suggested. The combined techniques such as LC–MS, GC–MS, and LC–NMR, which enable qualitative and quantitative analyses in one run, proved to be the most valuable in this case. Assembling of MS/MS spectra libraries of drug molecules and their phototransformation products was identified as the future challenge.

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Section: Photostability Testing Of Drugsmentioning

confidence: 73%

Studies on photodegradation process of psychotropic drugs: a review

Trawiński

Skibiński

2016

Environ Sci Pollut Res

106

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“…Robustness of the analytical method referred to its ability to remain unaffected by minute, but deliberate changes alterations in method parameters 16 . Robustness was studied by analyzing the effect of small and deliberate changes made in chromatographic conditions like, temperature of column, flow rate, pH and composition of mobile phase 25 .…”

Section: Robustnessmentioning

confidence: 99%

Method Development and Validation of Stability Indicating RP-HPLC Method for Simultaneous Estimation of Escitalopram Oxalate and Clonazepam in Bulk and its Pharmaceutical Formulations

Kalia

Baghel

2019

J. Drug Delivery Ther.

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This article refers to simple isocratic reverse-phase high-performance liquid chromatographic method (RP-HPLC) developed for the simultaneous quantification of Escitalopram Oxalate (EST) and Clonazepam (CZP) in active pharmaceutical ingredient and pharmaceuticals. The separation of the two drugs was attained using a C₁₈ column (250mm×4.6mm, 5µ) as a stationary phase. The mobile phase was used as a mixture of methanol; acetonitrile; and 0.05M potassium dihydrogen orthophosphate buffer (pH 4 adjusted by orthophosphoric acid) with an isocratic ratio of 40:20:40 v/v. Detection was made by using PDA detector at 210 nm. Escitalopram Oxalate (RT= 4.428 minutes) and Clonazepam (RT= 6.532 minutes) were separated in a single chromatographic run with resolution of 8.719. The calibration plot indicated good linear relationship with r2 = 0.998 for Escitalopram Oxalate in concentration range of 32 µg/ml - 48 µg/ml and r2 = 0.999 for Clonazepam in concentration range of 16 µg/ml - 24 µg/ml. The retrievals for Escitalopram Oxalate and Clonazepam were found to be 99.75% and 99.00%, respectively. The established analytical method was validated and found acceptable as per ICH guidelines for linearity, precision, accuracy, specificity, limit of detection, limit of quantification, robustness and stability. Escitalopram Oxalate and Clonazepam individually as well as in combination were exposed to different stress conditions like acid, base, thermal, photolytic and oxidation degradation and peaks of a degraded product were well determined from peaks of pure drug. This method is modest, quick and appropriate for routine quality control analysis. Keywords: Reverse Phase – HPLC; Escitalopram Oxalate; Clonazepam; Validation; Degradation study.

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“…Permasalahan kedua yaitu AMT, TFP, dan ALP diketahui tidak stabil terhadap paparan cahaya matahari atau sinar UV (Chauhan et al, 2017;Shetti and Venkatachalam, 2010;Trawiński and Skibiński, 2017). Oleh sebab itu, pada saat proses pembuatan dan penyimpanan harus dijauhkan dari jangkauan sinar matahari, tidak boleh dikemas di plastik klip biasa karena dapat merusak obat.…”

Section: Potensi Instabilitas Dan Inkompatibilitasunclassified

Kajian Potensi Inkompatibilitas dan Instabilitas: Studi Kasus Sediaan Racikan Mengandung Amitriptilin, Trifluoperazine Dihidroklorida dan Alprazolam

Kasanah

Putri

Yuliani

et al. 2019

J. Pharm. Sci. Clin. Res.

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<p>Meracik obat merupakan salah satu tugas tenaga kefarmasian. Peracikan obat merupakan salah satu risiko penyebab <em>medication error</em>. Resep racikan yang mengandung amitriptilin, trifluoperazin dihidroklorida dan alprazolam adalah jenis peresepan dengan tingkat risiko tinggi, sedangkan informasi tentang sediaan racikan kombinasi obat tersebut masih sangat terbatas. Studi ini bertujuan untuk memberikan informasi mengenai risiko peracikan, potensi instabilitas, dan potensi inkompatibilitas pada resep racikan sediaan kapsul yang mengandung amitriptilin, trifluoperazin dihidroklorida dan alprazolam di sebuah rumah sakit di Semarang. Analisis risiko resep dilakukan dengan memperhatikan aspek risiko teknis dan risiko klinis, sedangkan pengkajian terhadap potensi instabilitas dan inkompatibilitas dilakukan secara sistematis menggunakan beberapa literatur sengan kriteria yang telah ditetapkan. Hasil analisis risiko menunjukkan bahwa resep racikan mengandung amitriptilin, trifluoperazin dihidroklorida dan alprazolam memiliki risiko peracikan yang sangat tinggi. Berdasarkan penelusuran literatur sistematis, ditemukan adanya potensi ketidakstabilan dan inkompatibilitas yang mungkin terjadi yaitu penarikan lembab dan reaksi hidrolisis. Berbagai upaya teknis dapat dilakukan oleh tenaga kefarmasian untuk meningkatkan kualitas obat dan menjamin keamanannya yaitu menggunakan cangkang kapsul HPMC, menyimpan sediaan dalam wadah tertutup kedap, terhindar dari cahaya langsung pada suhu ruang dan menambahkan silika gel. Meskipun demikian, potensi instabilitas dan inkompatibilitas yang ditemukan dalam studi ini masih berdasar pada kajian pustaka, sehingga perlu dilakukan penelitian eksperimental untuk mengetahui profil stabilitas dan kompatibilitas sediaan racikan tersebut.</p>

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Stability Indicating HPLC Method for Simultaneous Quantification of Trihexyphenidyl Hydrochloride, Trifluoperazine Hydrochloride and Chlorpromazine Hydrochloride from Tablet Formulation

Cited by 10 publications

References 28 publications

Studies on photodegradation process of psychotropic drugs: a review

Studies on photodegradation process of psychotropic drugs: a review

Method Development and Validation of Stability Indicating RP-HPLC Method for Simultaneous Estimation of Escitalopram Oxalate and Clonazepam in Bulk and its Pharmaceutical Formulations

Kajian Potensi Inkompatibilitas dan Instabilitas: Studi Kasus Sediaan Racikan Mengandung Amitriptilin, Trifluoperazine Dihidroklorida dan Alprazolam

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