Stability Enhancement of Partially-Oxidized Porous Silicon Nanostructures Modified with Ethyl Undecylenate

Boukherroub, Rabah; Wayner, Danial D. M.; Sproule, G. I.; Lockwood, D. J.; Canham, Leigh

doi:10.1021/nl010061a

Cited by 78 publications

(72 citation statements)

References 23 publications

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“…The alkene end participates in the hydrosilylation reaction, bonding to the Si surface and leaving the carboxy-terminus free for further chemical modification. A favorite linker molecule is undecylenic acid, which provides a hydrophobic 10 carbon aliphatic chain to insulate the linker from the porous Si surface [85,120]. The drug payload can be attached directly to the carboxy group of the alkene, or it can be further separated from the surface with a PEG linker as shown in Fig.…”

Section: Incorporating a Payload Within The Porous Nanostructure By Cmentioning

confidence: 99%

Porous silicon in drug delivery devices and materials☆

Anglin

Cheng

Freeman

et al. 2008

Advanced Drug Delivery Reviews

801

618

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Porous Si exhibits a number of properties that make it an attractive material for controlled drug delivery applications: The electrochemical synthesis allows construction of tailored pore sizes and volumes that are controllable from the scale of microns to nanometers; a number of convenient chemistries exist for the modification of porous Si surfaces that can be used to control the amount, identity, and in vivo release rate of drug payloads and the resorption rate of the porous host matrix; the material can be used as a template for organic and biopolymers, to prepare composites with a designed nanostructure; and finally, the optical properties of photonic structures prepared from this material provide a self-reporting feature that can be monitored in vivo. This paper reviews the preparation, chemistry, and properties of electrochemically prepared porous Si or SiO 2 hosts relevant to drug delivery applications.

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Section: Incorporating a Payload Within The Porous Nanostructure By Cmentioning

confidence: 99%

Porous silicon in drug delivery devices and materials☆

Anglin

Cheng

Freeman

et al. 2008

Advanced Drug Delivery Reviews

801

618

View full text Add to dashboard Cite

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“…In particular, we have encountered such a problem while attempting to make a porSi surface hydrophilic by chemically binding linear hydrocarbons (unpublished data) by using chemical modification methods described elsewhere. [16,17] Although attached long-chain hydrocarbon molecules really imparted the wettability property to the porSi surface and stabilized the porSi luminescence, they prevented direct contact between Si nanocrystals and O 2 molecules and suppressed electronic energy transfer. In the present study physical adsorption of nonionic surfactants was used to render a porSi surface hydrophilic without loss of electronic contact between Si nanocrystals and O 2 molecules on the powder surface.…”

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confidence: 99%

Surfactant‐Modified Hydrophilic Nanostructured Porous Silicon for the Photosensitized Formation of Singlet Oxygen in Water

et al. 2007

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Porous silicon (porSi), which contains luminescent Si nanocrystal assemblies, is a promising semiconductor material for the photosensitized formation of singlet oxygen, 1 O 2 , for biological applications. However, because as-prepared luminescent Si nanocrystals are H-terminated and therefore hydrophobic, the first step to create a prototype of Si nanocrystalbased photosensitizer should be a modification of the Si nanocrystal surface with the aim to make it hydrophilic and able to work in a biological ambient. Such surface modification by surfactants should not, however, result in a decrease of the nanocrystals' durability that may, in principle, take place because of surfactant-induced weakening of surface tension and the consequent increase of interaction with H 2 O molecules. Surfactants should not also decrease the ability of the nanocrystals to transfer the excitation energy to acceptors (first of all molecular oxygen) on their surface. These rather contradictory tasks have been largely solved in the present work by use of nonionic surfactants physically adsorbed on the porSi surface.One of the strategic objectives of nanotechnology is the development of new materials of nanometer size that have entirely new physical properties, and, therefore, new functionality. Over the last decade, tailoring of material characteristics by size control has been demonstrated for many types of semiconductors. Optical and electronic properties of semiconductor nanocrystals can be simply engineered by changing their size and composition. When electrons and holes are squeezed into a dimension that approaches a critical size, quantum-confinement effects become apparent. This effect can be seen experimentally as a widening of the semiconductor nanocrystal bandgap.[1]

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“…The reaction of an hydrogen-terminated porous silicon surface with desoxygeneted undecylenic acid at 95 C for 16 H under argon results in the formation of a (CH 2 ) 10 chain attached to the silicon surface via an Si-C bond on one end, and terminated with a carboxylic acid on the other end. [9][10][11] These functionalized surfaces proved to be very stable in boiling CCl 4 and water, as well as in 100 % humidity atmosphere. Once the linker is anchored on the silicon surface, the next step is to anchor the receptor that will provide specificity to the sensing platform.…”

Section: Introductionmentioning

confidence: 97%

Functional nanostructured platforms for chemical and biological sensing

Létant

2006

SPIE Proceedings

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The central goal of our work is to combine semiconductor nanotechnology and surface functionalization in order to build platforms for the selective detection of bio-organisms ranging in size from bacteria (micron range) down to viruses, as well as for the detection of chemical agents (nanometer range). We will show on three porous silicon platforms how pore geometry and pore wall chemistry can be combined and optimized to capture and detect specific targets. We developed a synthetic route allowing to directly anchor proteins on silicon surfaces and illustrated the relevance of this technique by immobilizing live enzymes onto electrochemically etched luminescent nano-porous silicon. The powerful association of the specific enzymes with the transducing matrix led to a selective hybrid platform for chemical sensing.We also used light-assisted electrochemistry to produce periodic arrays of through pores on pre-patterned silicon membranes with controlled diameters ranging from many microns down to tens of nanometers. We demonstrated the first covalently functionalized silicon membranes and illustrated their selective capture abilities with antibody-coated micro-beads. These engineered membranes are extremely versatile and could be adapted to specifically recognize the external fingerprints (size and coat composition) of target bio-organisms. Finally, we fabricated locally functionalized single nanopores using a combination of focused ion beam drilling and ion beam assisted oxide deposition. We showed how a silicon oxide ring can be grown around a single nanopore and how it can be functionalized with DNA probes to detect single viral-sized beads. The next step for this platform is the detection of whole viruses and bacteria.

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Stability Enhancement of Partially-Oxidized Porous Silicon Nanostructures Modified with Ethyl Undecylenate

Cited by 78 publications

References 23 publications

Porous silicon in drug delivery devices and materials☆

Porous silicon in drug delivery devices and materials☆

Surfactant‐Modified Hydrophilic Nanostructured Porous Silicon for the Photosensitized Formation of Singlet Oxygen in Water

Functional nanostructured platforms for chemical and biological sensing

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