Stability Constants of Calcium, Magnesium and Zinc Gallate Using A Divalent Ion-Selective Electrode

Sandmann, Beverly J.; Chien, May H.; Sandmann, Robert A.

doi:10.1080/00032718508068758

Cited by 12 publications

(8 citation statements)

References 3 publications

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“…AntiOxBEN 3 protective effects may be related with its antioxidant activity, interference with one of the mPTP components or through the chelation of calcium ions. The capability of gallic acid chelate zinc, calcium, and magnesium metals and the stability of such complexes confirmed the evidence that phenolic chelators possess chelating power either for mono and divalent metals 48 , although it is possible that in our present case, and based on the stoichiometry of the complexation reactions, some free calcium may still be available. Recently, it was demonstrated that gallic acid prevented mitochondrial swelling induced by different stimuli independent of calcium overload, suggesting that it act as a genuine inhibitor of mPTP and not by affecting mitochondrial calcium loading 49 .…”

Section: Resultssupporting

confidence: 79%

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

Teixeira

Oliveira

Cagide

et al. 2018

Journal of Enzyme Inhibition and Medicinal Chemistry

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Pharmacological interventions targeting mitochondria present several barriers for a complete efficacy. Therefore, a new mitochondriotropic antioxidant (AntiOxBEN3) based on the dietary antioxidant gallic acid was developed. AntiOxBEN3 accumulated several thousand-fold inside isolated rat liver mitochondria, without causing disruption of the oxidative phosphorylation apparatus, as seen by the unchanged respiratory control ratio, phosphorylation efficiency, and transmembrane electric potential. AntiOxBEN3 showed also limited toxicity on human hepatocarcinoma cells. Moreover, AntiOxBEN3 presented robust iron-chelation and antioxidant properties in both isolated liver mitochondria and cultured rat and human cell lines. Along with its low toxicity profile and high antioxidant activity, AntiOxBEN3 strongly inhibited the calcium-dependent mitochondrial permeability transition pore (mPTP) opening. From our data, AntiOxBEN3 can be considered as a lead compound for the development of a new class of mPTP inhibitors and be used as mPTP de-sensitiser for basic research or clinical applications or emerge as a therapeutic application in mitochondria dysfunction-related disorders.

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Section: Resultssupporting

confidence: 79%

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

Teixeira

Oliveira

Cagide

et al. 2018

Journal of Enzyme Inhibition and Medicinal Chemistry

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“…The dependence of the ionization constant of the acids on the ionic strength was explicitly considered in the calculation. Unfortunately, data on the protonation constant of these acids are only reported at a few ionic strengths and in the low molal range (up to 0.1 mol/kg) [60][61][62][63][64][65][66]. Therefore, here, the K I for each acid was measured at 0.16 mol/kg and 0.51 mol/kg and its values at higher ionic strength, up to 3.5 mol/kg, were estimated by the SIT model at 37 • C (Equations ( 8)-( 11)).…”

Section: Thermodynamic Modelingmentioning

confidence: 99%

Modeling the Solubility of Phenolic Acids in Aqueous Media at 37 °C

et al. 2021

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In this work, the solubility of vanillic, gallic, syringic, p-coumaric, ferulic and caffeic acids was determined at 37 °C under different conditions, namely pure water and two different ionic media, NaCl(aq) and NaClO4(aq), at different ionic strengths (i.e., 0.16, 0.50, 1.0, 2.0 and 3.0 M). The solubility in water of all the acids was found to be higher than that in both of the ionic media. Moreover, the solubility of hydroxycinnamic acids was lower than that of hydroxybenzoic acids. The activity coefficients of neutral species were calculated from these data; this knowledge is necessary when modeling the dependence of equilibrium constants on the ionic strength. Results obtained in this work can be useful for further studies regarding complex formation equilibria between these ligands and bioavailable metal cations.

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“…An ion‐selective electrode with a single junction reference electrode has been developed to determine the stability constants of Ca, Mg, and Zn gallates [33] . Krishnan et al.…”

Section: Introductionmentioning

confidence: 99%

“…An ion-selective electrode with a single junction reference electrode has been developed to determine the stability constants of Ca, Mg, and Zn gallates. [33] Krishnan et al have also studied the influence of citrate, mandelate, and succinate on the titanium(VI) gallic acid system. [34] They found that citrate and mandelate form mixed complexes with titanium and gallic acid.…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis and Application of Chemically Modified Amberlite XAD‐2 for Separation and Preconcentration of Pb(II)

et al. 2023

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A highly selective, efficient, green analytical method was developed to separate and preconcentrate trace amounts of lead from aqueous samples using gallic acid‐immobilized Amberlite XAD‐2. The method was designed by determining the stability constant of the Pb‐GA complex and plotting the chemical speciation diagram, which indicated strong complexation of Pb(II) with GA (log βPb‐GA=9.50). The species distribution curve for the Pb‐GA complex indicates almost 98 % complexation, forming Pb‐GA as the predominant species. Considering the strong interaction of GA toward the lead, GA was immobilized on the polymeric matrix of Amberlite XAD‐2, and the conditions for the uptake of lead from the aqueous solutions were optimized by both batch and column methods. The sorption capacity and concentration factor of modified Amberlite XAD‐2 for Pb(II) were found to be 4554 μg g−1 and100 respectively. The method was employed for the determination of lead in various wastewater samples. Molecular modeling studies were also performed on GA‐immobilized Amberlite XAD‐2 to determine the active structure of GA on the surface.

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Stability Constants of Calcium, Magnesium and Zinc Gallate Using A Divalent Ion-Selective Electrode

Cited by 12 publications

References 3 publications

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

Discovery of a new mitochondria permeability transition pore (mPTP) inhibitor based on gallic acid

Modeling the Solubility of Phenolic Acids in Aqueous Media at 37 °C

Design, Synthesis and Application of Chemically Modified Amberlite XAD‐2 for Separation and Preconcentration of Pb(II)

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