Stability and transitions of depressive subtypes over a 2-year follow-up

Lamers, Femke; Rhebergen, Didi; Merikangas, Kathleen R.; Jonge, de Peter; Beekman, Aartjan T.F.; Penninx, Brenda W. J. H.

doi:10.1017/s0033291712000141

Cited by 72 publications

(64 citation statements)

References 49 publications

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“…Two classes were characterized by high severity and were labeled “severe typical” and “severe atypical” based on symptom profiles. Consistent with other latent modeling studies(12–16;18) the most discriminating symptoms were appetite and weight, decreased in typical and increased in atypical. Of note, LCA-subtypes do not necessarily overlap with DSM classification of melancholic and atypical.…”

Section: Methodssupporting

confidence: 89%

“…First, lifetime depression symptoms were used as input variables in a latent class analysis (LCA; Supplemental Methods) clustering persons on the basis of their endorsed symptom profiles. A 3-class model was found to fit the data best, similarly to previous results obtained applying LCA to NESDA patients with current MDD (extensive descriptions of subtypes and their correlates have been previously published (15;16;18)). Two classes were characterized by high severity and were labeled “severe typical” and “severe atypical” based on symptom profiles.…”

Section: Methodssupporting

confidence: 77%

“…The overlap between schizophrenia genetic risk and typical MDD is consistent with the common presence of psychotic symptoms in patients with melancholic depression(46). Furthermore, previous findings from NESDA cohort showed that patients categorized as severe typical were more likely to be smoker(15;16;18); smoking is highly comorbid with psychiatric disorders, especially with schizophrenia, although the underlying biology is not well understood(47). For the atypical subtype, converging epidemiological evidence suggests a correlation with obesity and immuno-metabolic alterations(11;18;19).…”

Section: Discussionmentioning

confidence: 99%

“…Intriguingly, the differential polygenic signatures were found when deriving subtypes by LCA applied to all endorsed symptoms or by simply coding the direction of change (increase/decrease) in the highly discriminatory(12–16;18) symptoms of appetite and weight. It should be highlighted that while increased appetite/weight almost perfectly predicted LCA-atypical, the decreased appetite/weight→LCA-typical prediction was less accurate, suggesting that other symptoms beyond appetite/weight may be relevant to reliably identify this subtype.…”

Section: Discussionmentioning

confidence: 99%

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Polygenic dissection of major depression clinical heterogeneity

et al. 2015

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The molecular mechanisms underlying Major Depressive Disorder (MDD) are largely unknown. Limited success of previous genetics studies may be attributable to heterogeneity of MDD, aggregating biologically different subtypes. We examined the polygenic features of MDD and two common clinical subtypes (typical and atypical) defined by symptom profiles in a large sample of adults with established diagnoses. Data were from 1,530 patients of the Netherlands Study of Depression and Anxiety (NESDA) and 1,700 controls mainly from the Netherlands Twin Register (NTR). Diagnoses of MDD and its subtypes were based on DSM-IV symptoms. Genetic overlap of MDD and subtypes with psychiatric (MDD, bipolar disorder, schizophrenia) and metabolic (BMI, C-reactive protein, triglycerides) traits was evaluated via genomic profile risk scores (GPRS) generated from meta-analysis results of large international consortia. SNP-heritability of MDD and subtypes was also estimated. MDD was associated with psychiatric GPRS, while no association was found for GPRS of metabolic traits. MDD subtypes had differential polygenic signatures: typical was strongly associated with schizophrenia GPRS (OR=1.54, p=7.8e-9), while atypical was additionally associated with BMI (OR=1.29, p=2.7e-4) and triglycerides (OR=1.21, p=0.006) GPRS. Similar results were found when only the highly discriminatory symptoms of appetite/weight to were used to define subtypes. SNP-heritability was 32% for MDD, 38% and 43% for subtypes with, respectively, decreased (typical) and increased (atypical) appetite/weight. In conclusion, MDD subtypes are characterized by partially distinct polygenic liabilities and may represent more homogeneous phenotypes. Disentangling MDD heterogeneity may help the psychiatric field moving forward in the search for molecular roots of depression.

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Section: Methodssupporting

confidence: 89%

Section: Methodssupporting

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Polygenic dissection of major depression clinical heterogeneity

et al. 2015

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“…Conversely, negative aspects of parenting may exacerbate children’s risk for developing mental health problems of their own. As depression is a heterogeneous disorder (American Psychiatric Association, & DSM-5 Task Force, 2013; Lamers et al, 2012; Østergaard, Jensen, & Bech, 2011) it is reasonable to expect that mothers with depressive symptoms may engage in a wide range of parenting behaviors, spanning both positive behaviors, such as acceptance and consistent discipline, and negative behaviors, such as rejection and physical punishment. This study examined whether positive and negative aspects of maternal parenting mitigated or exacerbated the effects of maternal depressive symptoms on initial levels and trajectories of child adjustment problems.…”

mentioning

confidence: 99%

Parenting as a Moderator of the Effects of Maternal Depressive Symptoms on Preadolescent Adjustment

Zalewski

Thompson

Lengua

2015

Journal of Clinical Child & Adolescent Psychology

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Objective The purpose of this study was to examine whether parenting moderated the association between maternal depressive symptoms and initial levels and growth of preadolescent internalizing and externalizing symptoms. Method This study used a community sample of pre-adolescent children (N=214; 8–12 years old at Time 1), measuring maternal depressive symptoms and parenting at Time 1, and preadolescent internalizing and externalizing symptoms at each year for 3 years. Results After modeling latent growth curves of internalizing and externalizing symptoms, growth factors were conditioned on maternal depressive symptoms, positive (acceptance and consistent discipline) and negative (rejection and physical punishment) parenting, and the interactions of depression and parenting. Maternal rejection moderated the relation of maternal depression with internalizing symptoms, such that high rejection exacerbated the effects of maternal depressive symptoms on initial levels of preadolescent internalizing problems. There were no significant interactions predicting externalizing problems. Conclusion The findings highlight how specific parenting behaviors may alter the way in which maternal depressive symptoms confer risk for behavior problems.

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