“…Cortical thickness increases until approximately age 2, whereas cortical surface area increases, depending on the region, until adolescence, making it more vulnerable to early life stressors (71)(72)(73)(74). In addition, cortical surface area alterations have been found to be associated with early onset depression (75,76), and prior research shows that the increased appetite, or atypical neurovegetative, subtype is associated with earlier onset of depression (13,19,24). However, since this study consisted of adolescents and young adults, the age of onset was low overall and did not differ between subtypes.…”