Stability and toxicity of differently coated selenium nanoparticles under model environmental exposure settings

Selmani, Atiđa; Ulm, Lea; Kasemets, Kaja; Kurvet, Imbi; Erceg, Ina; Barbir, Rinea; Pem, Barbara; Santini, Paula Tristão; Marion, Ida Delač; Vinković, Tomislav; Krivohlavek, Adela; Sikirić, Maja Dutour; Kahru, Anne; Vrček, Ivana Vinković

doi:10.1016/j.chemosphere.2020.126265

Cited by 32 publications

(18 citation statements)

References 25 publications

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“…However, in spite of the positively charged PVP, PVP‐SeNPs presented negative zeta‐potential values, which can be explained by the attachment of selenite on the surface of the particles. [ 138 ]…”

Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

“…In general, the charge of SeNPs is negative, [ 37,138,121 ] however surface modification with positive charged compounds such as chitosan can also flip the charge of SeNPs to positive. [ 123,121 ] Also, the coating with different enantiomers can produce SeNPs with different characteristics.…”

Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

“…Overall, SeNPs toxicity is related to it increasing ROS generation and cell membrane disruption. [ 36,138,171 ] Kalishwaralal et al have studied the effects of SeNPs on Zebrafish embryos, a species that share 85% of human genome, demonstrating that although no evident mortality appeared at lower concentrations (5–10 µg mL −1 ), exposure to high concentrations (20–25 µg mL −1 ) resulted in a considerable percentage of mortality, with abnormalities appearing, such as cardiac malfunction (blood congestion at the cardiac inflow tract and resultant pericardial edema and decrease of heart rate) and tail malfunction. [ 153 ]…”

Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

“…For example, spherical SeNPs have been proved to have high biological applications, while Se nanowires have high photoconductivity. [ 79 ] Overall, SeNPs are produced by reducing Se oxyanions into elemental Se, leading to solutions with color ranging from pink, orange, and red, [ 89,101,138 ] due to the excitations of the SeNPs surface plasmon resonance formed in the reaction mixture, [ 153 ] presenting a maximum absorption at 200–400 nm. [ 134 ] Therefore, SeNPs photoelectron spectroscopy pattern includes the distinctive Se 3d peak around 54–56 eV, as well as the Se 3p3, Se 3p1 and Sed3 peaks, [ 155,157 ] confirming the formation of its zero‐valent oxidation state, although usually accompanied by the peak correspondent to a residual Se(IV), around 56–60 eV.…”

Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

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Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Ferro

Florindo

Santos

2021

Adv Healthcare Materials

236

146

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Selenium (Se) is an essential element to human health that can be obtained in nature through several sources. In the human body, it is incorporated into selenocysteine, an amino acid used to synthesize several selenoproteins, which have an active center usually dependent on the presence of Se. Although Se shows several beneficial properties in human health, it has also a narrow therapeutic window, and therefore the excessive intake of inorganic and organic Se‐based compounds often leads to toxicity. Nanoparticles based on Se (SeNPs) are less toxic than inorganic and organic Se. They are both biocompatible and capable of effectively delivering combinations of payloads to specific cells following their functionalization with active targeting ligands. Herein, the main origin of Se intake, its role on the human body, and its primary biomedical applications are revised. Particular focus will be given to the main therapeutic targets that are explored for SeNPs in cancer therapies, discussing the different functionalization methodologies used to improve SeNPs stability, while enabling the extensive delivery of drug‐loaded SeNP to tumor sites, thus avoiding off‐target effects.

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Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

Section: Preparation and Characterization Methods Of Se Nanoparticles (Senps)mentioning

confidence: 99%

See 2 more Smart Citations

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Ferro

Florindo

Santos

2021

Adv Healthcare Materials

236

146

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“…Often, commercial NPs are surface-coated to increase their colloidal stability. The latter, however, makes them more motile in an aqueous environment [ 9 ]. Moreover, upon release to the environment, the NPs will be transformed being exposed to dissolved oxygen, dissolved organic matter (DOM), various ions, etc.…”

Section: Introductionmentioning

confidence: 99%

Effects of Humic Acids on the Ecotoxicity of Fe3O4 Nanoparticles and Fe-Ions: Impact of Oxidation and Aging

et al. 2020

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The magnetite nanoparticles (MNPs) are increasingly produced and studied for various environmental applications, yet the information on their ecotoxicity is scarce. We evaluated the ecotoxicity of MNPs (~7 nm) before and after the addition of humic acids (HAs). White mustard Sinapis alba and unicellular ciliates Paramecium caudatum were used as test species. The MNPs were modified by HAs and oxidized/aged under mild and harsh conditions. Bare MNPs proved not toxic to plants (96 h EC50 > 3300 mg/L) but the addition of HAs and mild oxidation increased their inhibitory effect, especially after harsh oxidation (96 h EC50 = 330 mg/L). Nevertheless, all these formulations could be ranked as ‘not harmful’ to S. alba (i.e., 96 h EC50 > 100 mg/L). The same tendency was observed for ciliates, but the respective EC50 values ranged from ‘harmful’ (24 h EC50 = 10–100 mg/L) to ‘very toxic’ (24h EC50 < 1 mg/L). The ecotoxicity of Fe-ions with and without the addition of HAs was evaluated in parallel: Fe (II) and Fe (III) ions were toxic to S. alba (96 h EC50 = 35 and 60 mg/L, respectively) and even more toxic to ciliates (24 h EC50 = 1 and 3 mg/L, respectively). Addition of the HAs to Fe-ions yielded the respective complexes not harmful to plants (96h EC50 > 100 mg/L) but toxic to ciliates (24h EC50 = 10–100 mg/L). These findings will be helpful for the understanding of the environmental fate and toxicity of iron-based NPs.

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Effects of Natural Organic Matter on Bioavailability of Elements from Inorganic Nanomaterial

Urík

Kolenčík

Fujitake

et al. 2021

Nanotechnology in Plant Growth Promotion and Protection

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Stability and toxicity of differently coated selenium nanoparticles under model environmental exposure settings

Cited by 32 publications

References 25 publications

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Selenium Nanoparticles for Biomedical Applications: From Development and Characterization to Therapeutics

Effects of Humic Acids on the Ecotoxicity of Fe3O4 Nanoparticles and Fe-Ions: Impact of Oxidation and Aging

Effects of Natural Organic Matter on Bioavailability of Elements from Inorganic Nanomaterial

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