Stability and mixing compatibility of dog epithelia and dog dander allergens

Allergen immunotherapy: A practice parameter third update

“…Studies designed to investigate the effect of combining mold/fungi extracts with pollen extracts have demonstrated a significant loss of potency of grass pollen, cat, birch, white oak, box elder, dog, and some weeds. 329,330,422,423 Cockroach had a similar deleterious effect on pollen extract potency. 422,424 The evidence on mixing cockroach extract with dust mite and ragweed extracts is conflicting.…”

“…There have been reports of interactions between extracts when mixed together. [328][329][330]422,423 Extracts such as Alternaria species have been shown to reduce the IgE-binding activity of timothy grass extract when mixed together. Studies designed to investigate the effect of combining mold/fungi extracts with pollen extracts have demonstrated a significant loss of potency of grass pollen, cat, birch, white oak, box elder, dog, and some weeds.…”

Environmental assessment and exposure control: a practice parameter—furry animals

“…In particular, dog Can f 3 exhibited degradation into discrete fragments though these retained IgE binding activity. 78 Cat Fel d 1 was more stable when incubated with protease-containing extracts, retaining most of its activity. 79 Both dog and cat extracts are more stable when stored in 50% glycerin than in aqueous form.…”

Update

“…It also appears that mite extracts are more resistant to degradation and also do not appear to have degrading properties. A few studies have been extended to investigate compatibility of dog allergen proteins when mixed with fungal or insect allergens [32], and whether pollens or mites are compatible with fire ant whole body extracts [33]. Dog dander and epithelial extract potency was measured by specific human IgE binding inhibition, Can f1, and immunoblotting.…”