Stability and metabolism of Arbutus unedo bioactive compounds (phenolics and antioxidants) under in vitro digestion and colonic fermentation

Mosele, Juana I.; Macià, Alba; Romero, Mari-Paz; Motilva, María‐José

doi:10.1016/j.foodchem.2016.01.076

Cited by 147 publications

(92 citation statements)

References 40 publications

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“…Catechin and quercetin induced significant increases in Bifidobacterium whereas puerarin was ineffective, and while quercetin and puerarin produced significant reductions in Bacteroides, catechin was much more potent [135]. Intact cell walls might significantly limit access of (poly)phenols-catabolising bacteria to their substrates [136], and Mosele et al demonstrated that a simulated duodenal digestion that degraded pectin increased microbial access to many substrates [137]. It has also been demonstrated in vitro that the exposure to (poly)phenols modulates the ability of the microbiota to metabolise fructo-oligosaccharides and to generate short chain fatty acids [138,139].…”

Section: Controls Used In Model Fermentations Have Clearly Demonstratmentioning

confidence: 99%

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Williamson

Clifford

2017

Biochemical Pharmacology

267

172

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Please cite this article as: G. Williamson, M.N. Clifford, Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols, Biochemical Pharmacology (2017), doi: http://dx.doi.org/10.1016/ j. bcp.2017.03.012 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1Role of the small intestine, colon and microbiota in determining the metabolic fate of in the small intestine, or reaches the colon and is subject to extensive catabolism by colonic microbiota. Untransformed substrates may be absorbed, appearing in plasma primarily as methylated, sulfated and glucuronidated derivatives, with in some cases the unchanged substrate. Many of the catabolites are well absorbed from the colon and appear in the plasma either similarly conjugated, or as glycine conjugates, or in some cases unchanged.Although many (poly)phenol catabolites have been identified in human plasma and / or urine, the pathways from substrate to final catabolite, and the species of bacteria and enzymes involved, are still scarcely reported. While it is clear that the composition of the human gut microbiota can be modulated in vivo by supplementation with some (poly)phenol-rich commodities, such modulation is definitely not an inevitable consequence of supplementation, it depends on the treatment, length of time and on the individual metabotype, and it is not clear whether the modulation is sustained when supplementation ceases. Some catabolites have been recorded in plasma of volunteers at concentrations similar to those shown to be effective in in vitro studies suggesting that some benefit may be achieved in vivo by diets yielding such catabolites. and are also present at high levels in supplements [4], and form essential components of many Chinese medicines [5]. A study within the European Prospective Investigation intoCancer and Nutrition (EPIC) using the Phenol Explorer database reported that the cohort studied consumed 427 different polyphenols including 94 that were consumed at a rate of >1 g/day. The estimated total polyphenol consumption ranged from 584 mg/day by Greek women to 1786 mg/day for men in Aarhus-Denmark. The corresponding data for Greek men and for Aarhus women were 744 mg/day and 1626 mg/ day, respectively, with all data adjusted for age and weighted by season and weekday of dietary recall [6]. This study defined the major contributors to be the phenolic acids (predominantly the caffeoylquinic acids (27-53%), also called chlorogenic acids) and flavonoids (predominantly flavanols (16-29%), proanthocyanidins (5-9%) and theaflavins (14-25%)) [6]. Hydroxybenzoic acids (3.3-7.4%), alkyl-phenols (1.6...

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Section: Controls Used In Model Fermentations Have Clearly Demonstratmentioning

confidence: 99%

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Williamson

Clifford

2017

Biochemical Pharmacology

267

172

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“…It is well known that all the bioactive compounds have beneficial effects at the systemic level and should be digested, absorbed and metabolised through the complex digestive system of the human body (Hanhineva et al, 2010). When estimating the potential functionality of a compound, it is more important to focus on the amount after gastrointestinal digestion rather than the original quantity since the phenolics undergo several oxidation and polymerisation reactions with pH change, leading to the formation of other high molecular weight or low solubility phenolic derivatives that are not available for absorption (Mosele et al, 2016). Furthermore, polyphenols may bind to some dietary constituents such as proteins, carbohydrates, fibre and iron, leading to a significant decrease after gastrointestinal digestion (Bermudez-Soto et al, 2007;He et al, 2015aHe et al, ,b, 2016a.…”

Section: Introductionmentioning

confidence: 99%

Stability of the phenolic compounds and antioxidant capacity of five fruit (apple, orange, grape, pomelo and kiwi) juices during in vitro‐simulated gastrointestinal digestion

Quan

Tao

Lü

et al. 2017

Int J of Food Sci Tech

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Summary The in vitro digestive stability of phenolic compounds and the antioxidant capacity of five kinds of commonly consumed fruit juices in the daily diet, including apple juice (AJ), orange juice (OJ), grape juice (GJ), pomelo juice (PJ) and kiwifruit juice (KJ), were studied. Following in vitro digestion, the total phenolic (TP) content of fruit juices decreased to different extents by 35%, 25.3%, 23.5%, 22.2% and 7.8% for KJ, OJ, PJ, GJ and AJ, respectively. The individual phenolic content showed similar changes to the TP content, showing reductions of naringenin‐trisaccharide in OJ and PJ, epicatechin in GJ, and chlorogenic acid in AJ by 43.74%, 27.59%, 47.11% and 33.28%, respectively. Conversely, the antioxidant capacity of fruit juices during digestion measured by ABTS assay increased from 4.79% to 35.53%, except in KJ, which decreased by 19.34%. These results show the health benefits of fruit juices after processing and contribute towards establishing suitable dietary recommendations.

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“…A. unedo is used and A. andrachne has the potential for use as an ornamental shrub in the urban and suburban landscape , while both are recommended species for reforestations in Mediterranean region, where fires are common, as they are characterized by vigorous re-sprouting after fire and overgrazing (Konstantinidis et al, 2006;Moreno-Jiménez, 2008;Kazanis et al, 2012). They both have high medicinal value (Diba et al, 2010;González et al, 2010;Afifi-Yazar et al, 2011;Mendes et al, 2011;Etxeberria et al, 2012;Abidi et al, 2015;Güler et al, 2015), while strawberry tree fruits are an excellent source of vitamin C, dietary fiber and total available carbohydrates, sugars, potassium and secondary metabolites, such as phenolic compounds, being poor in lipids and Na, with ascorbic acid and fat-soluble antioxidants (Ruiz-Rodríguez, 2011;Mosele et al, 2016) of higher values than other red small fruits (Guerreiro et al, 2013). They are also used for preparing liqueurs and aromatic traditional distillate (Soufleros et al, 2005;González et al, 2011;Botelho et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Morphometric and Molecular Analysis of the Three Arbutus Species of Greece

Bertsouklis

Papafotiou

2016

Not Bot Horti Agrobo

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Arbutus andrachne, A. unedo and A. × andrachnoides found in the Greek macchia are promising species for reforestations, ornamental use, as well as for medicinal use and the food industry. Μorphological traits and molecular markers (RAPD) were used to identify and distinguish these Arbutus species to facilitate their exploitation. Since there are no descriptors established for Arbutus spp., 23 qualitative morphological characteristics of crown, foliage, bark, flowering, fruiting, and four quantitative morphological characteristics of leaf and fruit were selected and used to define differences and similarities between sampled individuals of A. andrachne, A. unedo and individuals with intermediate characteristics sampled as A. × andrachnoides. Twenty eight individuals representative of three Arbutus taxa were sampled in two typical macchia forest areas of the prefecture of Attica, Greece. Cluster analysis based on morphological characteristics separated the individuals in three distinct groups, and this was confirmed by molecular analysis. Τhe intermediate form was indicated as A. × andrachnoides, a natural hybrid of A. andrachne and A. unedo. Fifteen 10-mer oligonucleotide arbitrary primers used to amplify genomic DNA generated 166 reproducible polymorphic fragments, which revealed that A. × andrachnoides has higher degree of genetic similarity with A. andrachne than A. unedo. The applied morphometric characteristics are suggested as a basis to develop a complete list of discriminating descriptors for Arbutus genus.

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Stability and metabolism of Arbutus unedo bioactive compounds (phenolics and antioxidants) under in vitro digestion and colonic fermentation

Cited by 147 publications

References 40 publications

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Stability of the phenolic compounds and antioxidant capacity of five fruit (apple, orange, grape, pomelo and kiwi) juices during in vitro‐simulated gastrointestinal digestion

Morphometric and Molecular Analysis of the Three Arbutus Species of Greece

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