Stability and Determination of Metamizole Sodium by Capillary Electrophoresis Analysis Combined with Infra-red Spectroscopy

Qian, Xiang; Niu, Guoguang; Wu, Xiujuan; Chen, G

doi:10.1016/s1005-9040(07)60142-1

Cited by 13 publications

(10 citation statements)

References 16 publications

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“…It is reported (Qian et al, 2007) that in aqueous media in the presence of oxygen, MT instantly transforms into MAA owing to a hydrolyzation-oxidation reaction (chemical structures of two substances are presented in Figure 3). We decided to investigate MT conversion into MAA in both water and organic media.…”

Section: Metamizole Stabilitymentioning

confidence: 99%

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4‐Methylamino antipyrine determination in human plasma by high‐performance liquid chromatography tandem mass spectrometry

Nikitina¹,

Gildeeva

Grigoriev

et al. 2020

Biomedical Chromatography

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In the present study, a simple and rapid method for metamizole metabolite 4‐methylamino antipyrine (MAA) determination in human plasma was developed, validated and successfully applied to a clinical trial. Chromatographic separation was achieved in HILIC mode on a YMC‐Pack SIL column (100 × 2.0 mm; S‐5 μm, 30 nm), with a mobile phase consisting of acetonitrile, water and formic acid. Protein precipitation of a small plasma volume using acetonitrile was selected for sample preparation. The multiple reaction monitoring transitions in the positive ionization mode were m/z 218.2 → 56.2 for MAA and m/z 221.2 → 56.2 for MAA‐d3 (IS, internal standard). Concentration levels of MAA calibration standards were in the range of 0.100–20 μg/ml. Metamizole conversion into MAA in both water and organic media was investigated, and the level of the conversion in commercially available injection solutions was estimated.

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Section: Metamizole Stabilitymentioning

confidence: 99%

“…It is reported (Qian, Gang, Xian-hua, & Gang, 2007) Acetonitrile (LC-MS grade) was purchased from Biosolve (Dieuze, France), methanol (MeOH, Gradient HPLC grade) was from J.T. Baker (Deventer, Netherlands), formic acid (≥98%) was from Merсk (Darmstadt, Germany) and ammonium acetate (>99.0%) was from Sigma-Aldrich (St Louis, MO, USA).…”

Section: Introductionmentioning

confidence: 99%

4‐Methylamino antipyrine determination in human plasma by high‐performance liquid chromatography tandem mass spectrometry

Nikitina¹,

Gildeeva

Grigoriev

et al. 2020

Biomedical Chromatography

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“…Oxidation electrode mechanism of sodium metamizole is complicated. [8][9][10]24 Analytical metamizole peak is most likely related with methylamino-N-methanesulfonate group.…”

Section: Characteristicmentioning

confidence: 99%

“…5 Because of possibly side effect for human health sodium metamizole has been withdrawn from the drug market in Northern Europe, USA, Japan and Australia, 6,29 but it is still very popular in other part of Europe and Latin America. 9 Nowadays various analytical procedures have been proposed to determinate sodium metamizole such as: spectrophotometry, 7,8 capillary electrophoresis, 9,10 UV, 11 chemiluminescence; 12,13 chromatography; 14,15 titrimetry, 16 flow injection analysis with amperometric, [17][18][19] bioamperomteric, 20 spectrophotometric 21,22,30 detection. So far in the literature several voltammetry methods were also described using: GC electrode, 23 carbon nanotube modified graphite-epoxy resin composite (GrEC) electrode, 24 platinum electrode coated with polymeric nickel-salen film, 3 carbon-paste electrode modified with N,N -ethylenebis(salicylideneaminato) oxovanadium(IV), 25 nano-riboflavin-modified glassy carbon electrode.…”

mentioning

confidence: 99%

Voltammetry and Flow Injection Analysis with Amperometric Detection for Sensitive Sodium Metamizole Determination on Glassy Carbon Electrode Modified with SWCNTs/Nafion

Rumin

Smajdor

Paczosa‐Bator

et al. 2016

ECS J. Solid State Sci. Technol.

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Novel, rapid and high sensitive voltametric methods and flow injection analysis were proposed for the determination of sodium metamizole on glassy carbon electrode modified with single-walled carbon nanotube with Nafion composite film. The results showed that SWCNT/Nafion remarkably enhanced the oxidation of metamizole which improved the anodic peak current of metamizole significantly. Under the optimized conditions peak current was proportional to sodium metamizole concentration in the range from 0.15 to 5 μM (DPV method) and from 20 to 100 μM (FIA method). The detection limit was 13 nM for DPV and 0.4 μM for FIA determination. The RSD for proposed methods were equal to 4.1% (n = 9) and 2.4% (n = 7) for voltammetry and FIA measurement respectively. Proposed methods were successfully validated by studying the recovery of metamizole in drugs and urine.

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“…As previously mentioned, storage conditions can have a huge impact on analyte stabilities and should therefore be taken very seriously. Several research articles have already examined the chemical stabilities of morphine (Ping et al, 2019 ; Vermeire, 1999 ), hydromorphone (Hildebrand et al, 2001 ; Nassr et al, 2003 ), metamizole (Xiang et al, 2007 ) and esketamine (Ancedy et al, 2021 ; Donnelly, 2013 ; Huvelle et al, 2016 ) in saline solution. However, it is hardly known whether these analgesics are also stable as mixtures.…”

Section: Introductionmentioning

confidence: 99%

Stability evaluation of morphine, hydromorphone, metamizole and esketamine containing analgesic mixtures applied for patient‐controlled analgesia in hospice and palliative care

Harder

Fiegl‐Lechner

Oberacher

et al. 2022

Biomedical Chromatography

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In this study, different injection solutions containing opioid and nonopioid compounds used for patient‐controlled analgesia in hospice and palliative care were evaluated in terms of analyte stability. Investigated injection solutions contained different combinations of morphine, hydromorphone, metamizole and esketamine. For the practical implementation, samples from infusion pumps were daily drawn over a period of 7 days at 22 and 37°C. Quantitative measurements were performed on a high‐performance liquid chromatography system with ultraviolet detection applying a validated analytical method. All compounds apart from morphine showed no evident changes in concentration. However, a significant loss of morphine was observed for injection mixtures containing both morphine and metamizole at 37°C. After 7 days, only 72% of the initially measured morphine concentration was measured in the binary and 77% in the ternary mixture. Furthermore, an additional compound was detected that could represent the morphine‐metamizole‐adduct, “metamorphine”. Based on these results, a significantly reduced morphine concentration must be expected after only 3 days if an injection solution mixture containing both morphine and metamizole is administered to a patient at 37°C. Since the analgesic effects of morphine–metamizole adducts have not yet been thoroughly investigated, further clinical studies are necessary before accurate conclusions can be drawn in this regard.

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Stability and Determination of Metamizole Sodium by Capillary Electrophoresis Analysis Combined with Infra-red Spectroscopy

Cited by 13 publications

References 16 publications

4‐Methylamino antipyrine determination in human plasma by high‐performance liquid chromatography tandem mass spectrometry

4‐Methylamino antipyrine determination in human plasma by high‐performance liquid chromatography tandem mass spectrometry

Voltammetry and Flow Injection Analysis with Amperometric Detection for Sensitive Sodium Metamizole Determination on Glassy Carbon Electrode Modified with SWCNTs/Nafion

Stability evaluation of morphine, hydromorphone, metamizole and esketamine containing analgesic mixtures applied for patient‐controlled analgesia in hospice and palliative care

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