Stability and controlled release of lutein loaded in zein nanoparticles with and without lecithin and pluronic F127 surfactants

Chuacharoen, Thanida; Sabliov, Cristina M.

doi:10.1016/j.colsurfa.2016.04.038

Cited by 121 publications

(67 citation statements)

References 29 publications

(3 reference statements)

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“…It appears that when the compounds are not encapsulated, they are more prone to loss due to volatilization and degradation than when they are encapsulated in nanoparticles. The results of this study therefore provide further evidence that encapsulation can protect active ingredients against rapid volatilization and degradation . Scremin et al , also observed that encapsulation of eugenol in rice‐bran protein‐based microcapsules provided protection to the active substance against degradation (around 30% compared to the non‐encapsulated compound).…”

Section: Resultssupporting

confidence: 69%

Association of zein nanoparticles with botanical compounds for effective pest control systems

Oliveira

Campos

Germano-Costa

et al. 2019

Pest Management Science

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BACKGROUND: Botanical compounds from plant species are known to have pesticidal activity and have been used in integrated pest management programs. The varied spectrum of the pesticidal action of these compounds can also avoid selection of resistance in pest populations. In this study, mixtures of the botanical compounds geraniol, eugenol and cinnamaldehyde were encapsulated in zein nanoparticles to improve their stability and efficiency. Biological effects of the nano-scale formulations of the botanical compounds were evaluated against two agricultural pests: the two-spotted spider mite (Tetranychus urticae) and the soybean looper (Chrysodeixis includes).RESULTS: The formulations were stable over time (120 days) with a high encapsulation efficiency (>90%). Nanoencapsulation also provided protection against degradation of the compounds during storage and led to a decrease in toxicity to non-target organisms. The release of the compounds (especially eugenol and cinnamaldehyde) from the nanoparticles was directly influenced by temperature, and the main mechanism of release was through a diffusion-based process. Nanoencapsulated compounds also showed superior efficiency compared to the emulsified compounds in terms of repellency and insecticidal activity. CONCLUSION:The findings of this study indicate that the convergence of botanical compounds with nano-scale formulation has the potential to improve efficacy for their sustainable use in integrated pest management in agriculture.

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Section: Resultssupporting

confidence: 69%

Association of zein nanoparticles with botanical compounds for effective pest control systems

Oliveira

Campos

Germano-Costa

et al. 2019

Pest Management Science

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“…Due to its ability to form nanoparticles, zein has been used to provide protection, stability, and as a delivery system to bioactive compounds (Wang et al., ). Among the bioactive compounds that have been encapsulated in zein nanoparticles and their respective obtention methods of obtaining are the following: resveratrol by antisolvent precipitation (Huang et al., ); rutin by antisolvent precipitation (Zhang, & Han, ); quercetagetin by antisolvent coprecipitation (Chen et al., ); curcumin by antisolvent precipitation and liquid–liquid dispersion (Hu, Wang, Fernandez, & Luo, ; Xue et al., ; Zou et al., ); vitamin A by phase separation (Park, Park, & Kim, ); vitamin D3 by phase separation (Luo, Teng, & Wang, ); procyanidins by liquid–liquid dispersion (Zou, Li, Percival, Bonard, & Gu, ), Tangeretin by liquid–liquid dispersion (Chen, Zheng, McClements, & Xiao, ); lutein by liquid–liquid dispersion (Chuacharoen & Sabliov, ), and quercetin by the desolvation procedure of an hydroalcoholic solution (Penalva, González‐Navarro, Gamazo, Esparza, & Irache, ). However, the previously noted methods by which zein nanoparticles with bioactive compounds have been obtained do not ensure that the entire solvent is removed from the nanoparticles, and an additional process is used, such as lyophilization, to obtain them in the form of powder, for which electrospraying comprises a technique that eliminates the entirety of the solvent and it can be obtained in powder in a single step.…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Currently, electrospraying is a novel process for obtaining the nanoparticles from biopolymers. Zein nanoparticles have been obtained by this method and used to protect both hydrophilic and hydrophobic antioxidant molecules from environmental factors. The objective of this work was to prepare and characterize gallic acid‐loaded zein nanoparticles obtained by the electrospraying process to provide protection to gallic acid from environmental factors. Thus, it was related to the concentration of gallic acid in physicochemical and rheological properties of the electrosprayed solution, and also to equipment parameters, such as voltage, flow rate, and distance of the collector in morphology, and particle size. The physicochemical properties showed a relationship in the formation of a Taylor cone, in which at a low concentration of gallic acid (1% w/v), low viscosity (0.00464 ± 0.00001 Pa·s), and density (0.886 ± 0.00002 g/cm3), as well as high electrical conductivity (369 ± 4.3 µs/cm), forms a stable cone‐jet mode. The rheological properties and the Power Law model of the gallic acid‐zein electrosprayed solution demonstrated Newtonian behavior (n = 1). The morphology and size of the particle were dependent on the concentration of gallic acid. Electrosprayed parameters with high voltage (15 kV), low flow rate (0.1 mL/hr), and short distance (10 cm) exhibited a smaller diameter and spherical morphology. FT–IR showed interaction in the gallic acid‐loaded zein nanoparticle by hydrogen bonds. Therefore, the electrospraying process is a feasible technique for obtaining gallic acid‐loaded zein nanoparticles and providing potential protection to gallic acid from environmental factors.

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“…However, zein nanoparticles have poor aggregation stability when exposed to certain environmental conditions, such as pH values around the isoelectric point, high salt levels, and elevated temperatures. This problem can be partially overcome by coating zein nanoparticles with emulsifiers, such as lecithin, small molecule surfactants, sodium caseinate, or sodium caseinate-dextran conjugates (Chen & Zhong, 2014;Chuacharoen & Sabliov, 2016b;Davidov-Pardo, Joye, Espinal-Ruiz, & McClements, 2015;Patel, Hu, Tiwari, & Velikov, 2010). Zein nanoparticle encapsulation protected resveratrol from isomerization by UV light (Davidov-Pardo, Joye, Espinal-Ruiz, & McClements, 2015), and increased its oral bioavailability (Penalva, Esparza, Larraneta, Gonzalez-Navarro, Gamazo, & Irache, 2015).…”

Section: Introductionmentioning

confidence: 99%

Resveratrol encapsulation in core-shell biopolymer nanoparticles: Impact on antioxidant and anticancer activities

et al. 2017

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Zein/pectin core-shell nanoparticles with average diameter of about 235 nm and polydipersity index (PDI) of 0.24 were developed to encapsulate, protect and deliver resveratrol. Biopolymer nanoparticles could be formed containing up to 10.2% (w/w) resveratrol, with a particle yield of 91.7% and a resveratrol loading efficiency of 77.9%. The nanoparticles formed were spherical and had good redispersibility in aqueous solutions. The encapsulated resveratrol had a higher in vitro antioxidant activity than free resveratrol as determined by DPPH•, ABTS• + scavenging ability, and iron (III) reducing power. The encapsulated resveratrol also exhibited higher antiproliferative activity when tested using human hepatocarcinoma Bel-7402 cells than free resveratrol, with IC 50 values of 17.6 µg/mL (77.2 µM) and 25.6 µg/mL (112.0 µM) respectively. The colloidal form of resveratrol developed in this study may be particularly useful for application in functional foods and beverages, as well as in dietary supplements and pharmaceutical products.

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Stability and controlled release of lutein loaded in zein nanoparticles with and without lecithin and pluronic F127 surfactants

Cited by 121 publications

References 29 publications

Association of zein nanoparticles with botanical compounds for effective pest control systems

Association of zein nanoparticles with botanical compounds for effective pest control systems

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Resveratrol encapsulation in core-shell biopolymer nanoparticles: Impact on antioxidant and anticancer activities

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