Stability and Applicability of Retinyl Palmitate Loaded Beeswax Microcapsules for Cosmetic Use

Abstract

In our previous study, retinyl palmitate was successfully encapsulated by melt dispersion using waxes as shell materials. Herein, the objective of the present research is to evaluate the shelf life and kinetic release of the developed microcapsules. The study was conducted by measuring actual loading capacity over a period of time using spectroscopic analysis. The transfer percentage of particles from nonwoven facial wipes to skin-like surfaces was also investigated by simulating the rubbing mechanism with a robotic transfer replicator. Although particles stored as powder form under room temperature showed only eight days of shelf-life, particles stored as a dispersion in a refrigerator maintained 60% of the theoretical loading capacity after one month. The kinetic release profile of the particles in ethanol with shaking at 100 rpm and 37 2ºC showed an initial burst in the first half an hour, followed by a sustained release. It also showed that 98% of the retinyl palmitate content released within 4 hours. Particles incorporated into wet nonwoven wipes gave approximately 22% transfer to skin-like fabric. Thus, the study shows potentials of delivering skincare properties by means of retinyl palmitate capsule loaded textile substrates.

Evaluation of Cell Proliferation and Wound Healing Effects of Vitamin A Palmitate-Loaded PLGA/Chitosan-Coated PLGA Nanoparticles: Preparation, Characterization, Release, and Release Kinetics

“…In skin that has been harmed by the sun, vitamin A helps to minimize keratoses and restore normal, supple skin . The use of VAP for cosmetic/dermacosmetic purposes is quite common. − A recent use for VAP is its use in wound healing…”

“… 25 The use of VAP for cosmetic/dermacosmetic purposes is quite common. 26 − 28 A recent use for VAP is its use in wound healing. 29…”