St. John’s Wort (Hypericum perforatum)

Belwal, Tarun; Devkota, Hari Prasad; Singh, Manoj Kumar; Sharma, Ruchika; Upadhayay, Sashi; Joshi, Charu; Bisht, Kapil; Gour, Jalaj Kumar; Bhatt, Indra D.; Rawal, Ranbeer S.; Pande, Veena

doi:10.1016/b978-0-12-812491-8.00056-4

Cited by 18 publications

(16 citation statements)

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“…Although the chemical composition of H. perforatum essential oils has been reported previously in several publications [ 9 , 11 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 ], there is a wide variation in the reported levels of secondary metabolites from different H. perforatum plant samples (see Table 1 for a summary of results from recent studies since 2010). This variability can impact the specific pharmacological activity of essential oils/extracts [ 40 , 41 ].…”

Section: Resultsmentioning

confidence: 95%

“…In addition, H. perforatum extracts have also been reported to have anti-angiogenic, anti-fibroblastic, and antioxidant properties [ 6 , 7 , 8 ]. The phytochemical profile of H. perforatum includes naphthodianthrones (specifically hypericin and pseudohypericin), hyperforin, proanthocyanins, flavonoids, biflavonoids, xanthones, phenylpropanes, phenolic acids, and volatile constituents [ 9 , 10 , 11 ]. Hypericum essential oils are rich sources of monoterpenes, sesquiterpenes, and their oxygenated derivatives (reviewed in [ 9 ] and Table 1, which has a listing of the more recent H. perforatum essential oil data published after this review).…”

Section: Introductionmentioning

confidence: 99%

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Chemical Composition and Immunomodulatory Activity of Hypericum perforatum Essential Oils

Schepetkin

Özek

et al. 2020

Biomolecules

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Hypericum L. (Hypericaceae) extracts have been used for their therapeutic effects; however, not much is known about the immunomodulatory activity of essential oils extracted from this plant. We isolated essential oils from the flowers and leaves of H. perforatum and analyzed their chemical composition and innate immunomodulatory activity. Analysis of flower (HEOFl) versus leaf (HEOLv) essential oils using gas chromatography–mass spectrometry revealed that HEOFl was comprised mainly of monoterpenes (52.8%), with an abundance of oxygenated monoterpenes, including cis-p-menth-3-en-1,2-diol (9.1%), α-terpineol (6.1%), terpinen-4-ol (7.4%), and limonen-4-ol (3.2%), whereas the sesquiterpenes were found in trace amounts. In contrast, HEOLv was primarily composed of sesquiterpenes (63.2%), including germacrene D (25.7%) and β-caryophyllene (9.5%). HEOLv also contained oxygenated monoterpenes, including terpinen-4-ol (2.6%), while monoterpene hydrocarbons were found in trace amounts. Both HEOFl and HEOLv inhibited neutrophil Ca2+ mobilization, chemotaxis, and reactive oxygen species (ROS) production, with HEOLv being much more active than HEOFl. Furthermore, the pure sesquiterpenes germacrene D, β-caryophyllene, and α-humulene also inhibited these neutrophil responses, suggesting that these compounds represented the active components of HEOLv. Although reverse pharmacophore mapping suggested that potential protein targets of germacrene D, β-caryophyllene, bicyclogermacrene, and α-humulene could be PIM1 and mitogen-activated protein kinase (MAPK)-activated protein kinase 2 (MAPKAK2), a kinase binding affinity assay did not support this finding, implying that other biological targets are involved. Our results provide a cellular and molecular basis to explain at least part of the beneficial immunotherapeutic properties of the H. perforatum essential oils.

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Section: Resultsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Immunomodulatory Activity of Hypericum perforatum Essential Oils

Schepetkin

Özek

et al. 2020

Biomolecules

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“…In the first study by Han et al, NS oil cream was compared to the Hypericum perforatum (HP) oil cream [41]. HP or its common name St. John's Wort, is another traditional herb known for its anti-inflammatory properties [54]. By the end of the study duration, the NS group demonstrated a significantly smaller wound area and higher wound contraction compared to the control group but the difference was not significant compared to the HP group [41].…”

Section: Gross Appearancesmentioning

confidence: 99%

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Sallehuddin

Nordin

Idrus

2020

IJERPH

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Nigella sativa (NS) has been reported to have a therapeutic effect towards skin wound healing via its anti-inflammatory, tissue growth stimulation, and antioxidative properties. This review examines all the available studies on the association of Nigella sativa (NS) and skin wound healing. The search was performed in Medline via EBSCOhost and Scopus databases to retrieve the related papers released between 1970 and March 2020. The principal inclusion criteria were original article issued in English that stated wound healing criteria of in vivo skin model with topically applied NS. The search discovered 10 related articles that fulfilled the required inclusion criteria. Studies included comprise different types of wounds, namely excisional, burn, and diabetic wounds. Seven studies unravelled positive results associated with NS on skin wound healing. Thymoquinone has anti-inflammatory, antioxidant, and antibacterial properties, which mainly contributed to wound healing process.

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“…Achillea millefolium L., commonly known as yarrow, has been used in traditional medicine for inflammatory and spasmodic gastrointestinal disorders, as an appetite-enhancing drug, for wound healing and diabetes ( 17 , 18 ). Hypericum perforatum L., commonly known as St. John's Wort, has been used for poor appetite, difficulty sleeping, nervousness, the treatment of burns, skin ulcers, and cuts ( 19 ). Satureja montana L., commonly known as winter savory, is used for digestive complaints, such as diarrhea, and colic ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

“…Lastly, Gentiana asclepiadea L., commonly known as willow gentian, is traditionally used for improving appetite, digestive problems, and hepatitis infections ( 21 ). All listed medicinal plants have proven antimicrobial, antioxidant, anticancer, and anti-inflammatory properties ( 18 , 19 , 22 – 25 ). The major active compounds in the St. John's wort are flavonoids (quercetin, biapigenin, hyperoside, rutin, quercitrin, and isoquercitrin), phenolic acids (chlorogenic, caffeic, p -coumaric, and ferulic acid), naphthodianthrones (hypericin and pseudohypericin), and phloroglucinols (hyperforin and adhyperforin) ( 19 , 22 , 26 ).…”

Section: Introductionmentioning

confidence: 99%

Plant Extracts Rich in Polyphenols as Potent Modulators in the Growth of Probiotic and Pathogenic Intestinal Microorganisms

Milutinović

Dimitrijević-Branković

Rajilić‐Stojanović

2021

Front. Nutr.

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Medicinal plants and their extracts contain substantial quantities of polyphenols. As metabolically active plant metabolites, polyphenols are food components with a wide range of biological activities. Given their poor absorbability in the digestive tract their activity toward the human host is typically mediated through interaction with intestinal microbes. As a result, polyphenols comprise a novel group of prebiotics. In this study, we tested the effect of five polyphenol-rich extracts from four medicinal herbs on the growth of probiotic and pathogenic microbes. The studied medicinal herbs were Gentiana asclepiadea L. (willow gentian), Hypericum perforatum L. (St. John's wort), Satureja montana L. (winter savory), and Achillea millefolium L. (yarrow). All these plants are traditionally used for the treatment of digestive problems. Extracts were prepared using safe solvent combinations. We tested the impact of addition of plant extracts on the growth of three probiotic lactobacilli and probiotic yeast Saccharomyces boulardii. The effect of addition of plant extracts to liquid media (concentration range 0.25–10 mg/mL) on the growth of probiotics, was tested in vitro. The antimicrobial activity of the extracts was tested against several opportunistic bacteria and yeast. St. John's wort, winter savory, and willow gentian extracts showed a stimulative effect on probiotic yeast growth, while the highest growth-stimulating effect was achieved when microwave-assisted yarrow extract was used in the concentration of 0.5 mg/mL. Under these conditions growth of S. boulardii was increased 130-fold. In addition, the yarrow extract stimulated the growth of Lactiplantibacillus plantarum 299v. The growth of two Lacticasibacillus rhamnosus strains was not stimulated by the addition of any extracts. Our results show that plant polyphenol-rich extracts can influence the growth of microorganisms that are typical members of the intestinal microbiota. For the first time we demonstrate that probiotic yeast growth can be stimulated by extracts of medicinal herbs, which when accompanied by suppression of Candida yeasts suggests a potential benefit of the treatment in diseases that are associated with fungal dysbiosis.

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St. John’s Wort (Hypericum perforatum)

Cited by 18 publications

References 124 publications

Chemical Composition and Immunomodulatory Activity of Hypericum perforatum Essential Oils

Chemical Composition and Immunomodulatory Activity of Hypericum perforatum Essential Oils

Nigella sativa and Its Active Compound, Thymoquinone, Accelerate Wound Healing in an In Vivo Animal Model: A Comprehensive Review

Plant Extracts Rich in Polyphenols as Potent Modulators in the Growth of Probiotic and Pathogenic Intestinal Microorganisms

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