SSH1 expression is associated with gastric cancer progression and predicts a poor prognosis

Maimaiti, Yusufu; Maimaitiming, Maimaitiaili; Li, Yiliang; Saifuding, Aibibula; Ainiwaer, Azatijiang; Aili, Aikebaier; Sun, Zhenzhu; Kelimu, Abudureyimu

doi:10.1186/s12876-018-0739-5

Cited by 12 publications

(12 citation statements)

References 24 publications

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“…SSH1-CDK13, SSH1-CDK19, SSH2-EPHB2 were identified with high significance. Slingshot phosphatases have been previously implicated in cancer progression [80,81] and have been known to mediate caspase-modulated actin polymerization towards bacterial clearance upon Legionella infection [82]. In our analysis, Slingshot phosphatase members SSH1, SSH2 were found to be downregulated exclusively in human DCs, while SSH3 was downregulated in both human DCs and MOs.…”

Section: Discussionmentioning

confidence: 54%

Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling

Subbannayya

Pinto

Bösl

et al. 2019

IJMS

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Dual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune response through the modulation of mitogen-activated protein kinases (MAPKs). Yet the precise interplay between the various members of the DUSP family with protein kinases is not well understood. Recent multi-omics studies characterizing the transcriptomes and proteomes of immune cells have provided snapshots of molecular mechanisms underlying innate immune response in unprecedented detail. In this study, we focus on deciphering the interplay between members of the DUSP family with protein kinases in immune cells using publicly available omics datasets. Our analysis resulted in the identification of potential DUSP-mediated hub proteins including MAPK7, MAPK8, AURKA, and IGF1R. Furthermore, we analyzed the association of DUSP expression with TLR4 signaling and identified VEGF, FGFR, and SCF-KIT pathway modules to be regulated by the activation of TLR4 signaling. Finally, we identified several important kinases including LRRK2, MAPK8, and cyclin-dependent kinases as potential DUSP-mediated hubs in TLR4 signaling. The findings from this study have the potential to aid in the understanding of DUSP signaling in the context of innate immunity. Further, this will promote the development of therapeutic modalities for disorders with aberrant DUSP signaling.

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Section: Discussionmentioning

confidence: 54%

Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling

Subbannayya

Pinto

Bösl

et al. 2019

IJMS

View full text Add to dashboard Cite

show abstract

“…SSH1-CDK13, SSH1-CDK19, SSH2-EPHB2 were identified with high significance. Slingshot phosphatases have been previously implicated in cancer progression [75,76] and have been known to mediate caspase-modulated actin polymerization towards bacterial clearance upon Legionella infection [77]. In our analysis, Slingshot phosphatase members SSH1, SSH2 were found to be downregulated exclusively in human DCs, while SSH3 was downregulated in both human DCs and MOs.…”

Section: Discussionmentioning

confidence: 56%

Dynamics of dual specificity phosphatases and their interplay with protein kinases in immune signaling

Subbannayya

Pinto

Bösl

et al. 2019

Preprint

View full text Add to dashboard Cite

Dual specificity phosphatases (DUSPs) have a well-known role as regulators of the immune response through the modulation of mitogen activated protein kinases (MAPKs). Yet the precise interplay between the various members of the DUSP family with protein kinases is not well understood. Recent multi-omics studies characterizing the transcriptomes and proteomes of immune cells have provided snapshots of molecular mechanisms underlying innate immune response in unprecedented detail. In this study, we focused on deciphering the interplay between members of the DUSP family with protein kinases in immune cells using publicly available omics datasets. Our analysis resulted in the identification of potential DUSPmediated hub proteins including MAPK7, MAPK8, AURKA, and IGF1R. Furthermore, we analyzed the association of DUSP expression with TLR4 signaling and identified VEGF, FGFR and SCF-KIT pathway modules to be regulated by the activation of TLR4 signaling. Finally, we identified several important kinases including LRRK2, MAPK8, and cyclin-dependent kinases as potential DUSP-mediated hubs in TLR4 signaling. The findings from this study has the potential to aid in the understanding of DUSP signaling in the context of innate immunity. Further, this will promote the development of therapeutic modalities for disorders with aberrant DUSP signaling.

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“…Wang et al [7] found that the expression of SSH-1 was to be upregulated in pancreatic cancer cell lines with high metastatic potential, and loss of SSH-1 was correlated with an increase in the phosphorylation of cofilin-1 and the inhibition of cancerous cell migration (but not proliferation). Moreover, SSH-1 was also significantly associated with lymph node metastasis in gastric cancer patients, and was an independent predictor of poor clinical outcomes in Maimaiti's research [8]. While, little is known regarding the SSH-1 expression in human stage pT1 bladder UC patients.…”

Section: Discussionmentioning

confidence: 96%

“…Yellow or brown staining indicated SSH-1 positivity. The SSH-1 staining scoring system is based on published research [8]. The intensity of SSH-1 in cancer cells was graded as 0-3, and the number of SSH-1( +) cells was graded as 0-4 according to the percentage of positive cells (0: 0-5%; 1: 6-25%; 2: 26-50%; 3: 51-75%; 4: 76-100%).…”

Section: Ihc and Scoringmentioning

confidence: 99%

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Slingshot homolog-1 expression is a poor prognostic factor of pT1 bladder urothelial carcinoma after transurethral resection

Luo

Liu

et al. 2020

World J Urol

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Objective Slingshot homolog-1 (SSH-1) shows an important role in the occurrence and development in various tumors. While, the expression and prognostic implications of SSH-1 in bladder urothelial carcinoma (UC) remain unclear and thus were addressed in this study. Methods Immunohistochemistry (IHC) was performed on tissue microarrays composed of 624 bladder UC specimens after transurethral resection of bladder tumor (TUR-BT) to detect SSH-1 expression. The clinic-pathological features were compared between SSH-1(+) and SSH-1(−) subgroups. The Kaplan-Meier curve with log-rank test and univariate/multivariate Cox regression model with stepwise backward elimination methods were performed for survival analyses. Results In this study, 359 (57.53%) specimens were detected with SSH-1 expression. SSH-1 positivity was significantly associated with higher pathological grade (p = 0.020), lymphovascular invasion (p = 0.006), tumor recurrence (p < 0.001) and progression (p < 0.001) in bladder UC. Besides, SSH-1 positivity predicted a shorter overall survival (OS, p = 0.024), recurrence-free survival (RFS, p < 0.001), progression-free survival (PFS, p = 0.002) and cancer-specific survival (CSS, p = 0.047). Multivariate Cox proportional hazard analysis showed that tumor size (p = 0.007), lymphovascular invasion (p = 0.003), recurrence (p < 0.001), progression (p < 0.001) and SSH-1 expression (p = 0.015) were predictors of poor prognosis in bladder UC patients. Conclusions SSH-1 expression was associated with undesirable clinic-pathological characteristics and poor post-operative prognosis in bladder UC patients. SSH-1 might play an important role in bladder UC and serve as a promising predictor of oncological outcomes in patients with bladder UC.

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SSH1 expression is associated with gastric cancer progression and predicts a poor prognosis

Cited by 12 publications

References 24 publications

Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling

Dynamics of Dual Specificity Phosphatases and Their Interplay with Protein Kinases in Immune Signaling

Dynamics of dual specificity phosphatases and their interplay with protein kinases in immune signaling

Slingshot homolog-1 expression is a poor prognostic factor of pT1 bladder urothelial carcinoma after transurethral resection

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