Sry-related High Mobility Group Box 17 Functions as a Tumor Suppressor by Antagonizing the Wingless-related Integration Site Pathway

Anani, Maha; Nobuhisa, Ikuo; Taga, Tetsuya

doi:10.15430/jcp.2020.25.4.204

Cited by 3 publications

(1 citation statement)

References 85 publications

(120 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, in the female only group, there was a trend that DMRs methylated in the tumor were more easily methylated in females. Among these genes, SRY (sex determining region Y)-box 17 ( SOX17 ) is a transcription factor important for esophagus tissue development and is hypermethylated in human cancers [ 40 ]. Moreover, the promoter hypermethylation of SOX17 correlates with poor chemoradiation therapy response in ESCC and SOX17 overexpression sensitizes the response through the downregulation of DNA repair genes or damage response genes [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Drug Repurposing Applications to Overcome Male Predominance via Targeting G2/M Checkpoint in Human Esophageal Squamous Cell Carcinoma

Yin

Feng

et al. 2022

Cancers

View full text Add to dashboard Cite

Esophageal squamous cell carcinoma (ESCC) is strongly characterized by a male predominance with higher mortality rates and worse responses to treatment in males versus females. Despite the role of sex hormones, other causes that may contribute to sex bias in ESCC remain largely unknown, especially as age increases and the hormone difference begins to diminish between sexes. In this study, we analyzed genomics, transcriptomics, and epigenomics from 663 ESCC patients and found that G2/M checkpoint pathway-related sex bias and age bias were significantly present in multi-omics data. In accordance with gene expression patterns across sexes, ten compounds were identified by applying drug repurposing from three drug sensitivity databases: The Connective Map (CMap), Genomics of Drug Sensitivity in Cancer (GDSC), and The Cancer Therapeutic Response Portal (CTRP). MK1775 and decitabine showed better efficacy in two male ESCC cell lines in vitro and in vivo. The drugs’ relevance to the transition between G2 and M was especially evident in male cell lines. In our study, we first validated the sex bias of the G2/M checkpoint pathway in ESCC and then determined that G2/M targets may be included in combination therapy for male patients to improve the efficacy of ESCC treatment.

show abstract

Section: Resultsmentioning

confidence: 99%

Drug Repurposing Applications to Overcome Male Predominance via Targeting G2/M Checkpoint in Human Esophageal Squamous Cell Carcinoma

Yin

Feng

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

Methylation signatures as biomarkers for non-invasive early detection of breast cancer: A systematic review of the literature

Gonzalez,

Nie,

Chaudhary

et al. 2024

Cancer Genetics

View full text Add to dashboard Cite

Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer

Otálora‐Otálora

López‐Kleine

Rojas

2023

CIMB

View full text Add to dashboard Cite

The transcriptomic analysis of microarray and RNA-Seq datasets followed our own bioinformatic pipeline to identify a transcriptional regulatory network of lung cancer. Twenty-six transcription factors are dysregulated and co-expressed in most of the lung cancer and pulmonary arterial hypertension datasets, which makes them the most frequently dysregulated transcription factors. Co-expression, gene regulatory, coregulatory, and transcriptional regulatory networks, along with fibration symmetries, were constructed to identify common connection patterns, alignments, main regulators, and target genes in order to analyze transcription factor complex formation, as well as its synchronized co-expression patterns in every type of lung cancer. The regulatory function of the most frequently dysregulated transcription factors over lung cancer deregulated genes was validated with ChEA3 enrichment analysis. A Kaplan–Meier plotter analysis linked the dysregulation of the top transcription factors with lung cancer patients' survival. Our results indicate that lung cancer has unique and common deregulated genes and transcription factors with pulmonary arterial hypertension, co-expressed and regulated in a coordinated and cooperative manner by the transcriptional regulatory network that might be associated with critical biological processes and signaling pathways related to the acquisition of the hallmarks of cancer, making them potentially relevant tumor biomarkers for lung cancer early diagnosis and targets for the development of personalized therapies against lung cancer.

show abstract

Sry-related High Mobility Group Box 17 Functions as a Tumor Suppressor by Antagonizing the Wingless-related Integration Site Pathway

Cited by 3 publications

References 85 publications

Drug Repurposing Applications to Overcome Male Predominance via Targeting G2/M Checkpoint in Human Esophageal Squamous Cell Carcinoma

Drug Repurposing Applications to Overcome Male Predominance via Targeting G2/M Checkpoint in Human Esophageal Squamous Cell Carcinoma

Methylation signatures as biomarkers for non-invasive early detection of breast cancer: A systematic review of the literature

Lung Cancer Gene Regulatory Network of Transcription Factors Related to the Hallmarks of Cancer

Contact Info

Product

Resources

About