Methylation signatures as biomarkers for non-invasive early detection of breast cancer: A systematic review of the literature

Gonzalez, Tessa; Nie, Qian; Chaudhary, Lubna N.; Basel, Donald; Reddi, Honey V.

doi:10.1016/j.cancergen.2023.12.003

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2024

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Cited by 3 publications

References 52 publications

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Epigenetics and Carcinogenesis

Goodrich,

Polemi,

Dolinoy

2024

Reference Module in Biomedical Sciences

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Epigenetics and Carcinogenesis

Goodrich,

Polemi,

Dolinoy

2024

Reference Module in Biomedical Sciences

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Genetic expression in cancer research: Challenges and complexity

Liu,

Guo,

Wang

2024

Gene Reports

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Identification of the novel exhausted T cell CD8 + markers in breast cancer

Liu,

Dong,

Rasteh

et al. 2024

Sci Rep

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Cancer is one of the most concerning public health issues and breast cancer is one of the most common cancers in the world. The immune cells within the tumor microenvironment regulate cancer development. In this study, single immune cell data sets were used to identify marker gene sets for exhausted CD8 + T cells (CD8Tex) in breast cancer. Machine learning methods were used to cluster subtypes and establish the prognostic models with breast cancer bulk data using the gene sets to evaluate the impacts of CD8Tex. We analyzed breast cancer overexpressing and survival-associated marker genes and identified CD8Tex hub genes in the protein–protein-interaction network. The relevance of the hub genes for CD8 + T-cells in breast cancer was evaluated. The clinical associations of the hub genes were analyzed using bulk sequencing data and spatial sequencing data. The pan-cancer expression, survival, and immune association of the hub genes were analyzed. We identified biomarker gene sets for CD8Tex in breast cancer. CD8Tex-based subtyping systems and prognostic models performed well in the separation of patients with different immune relevance and survival. CRTAM, CLEC2D, and KLRB1 were identified as CD8Tex hub genes and were demonstrated to have potential clinical relevance and immune therapy impact. This study provides a unique view of the critical CD8Tex hub genes for cancer immune therapy.

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Methylation signatures as biomarkers for non-invasive early detection of breast cancer: A systematic review of the literature

Cited by 3 publications

References 52 publications

Epigenetics and Carcinogenesis

Epigenetics and Carcinogenesis

Genetic expression in cancer research: Challenges and complexity

Identification of the novel exhausted T cell CD8 + markers in breast cancer

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