Squid type II collagen as a novel biomaterial: Isolation, characterization, immunogenicity and relieving effect on degenerative osteoarthritis via inhibiting STAT1 signaling in pro-inflammatory macrophages

Evaluation of the Potential of Collagen from Codfish Skin as a Biomaterial for Biomedical Applications

“…Besides fish, many other marine organisms from different taxa have been studied as origins of biomass for the extraction of collagen, from a fundamental perspective or as raw-material for biopolymer production. Examples can be found on marine sponges [10,11,12,13,14,15], jellyfish [16,17,18], anemones [19,20], corals [21], squids [22,23,24] and different echinoderms [25,26,27].…”

Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping

“…Further, due to the high variability in peptide composition between CH preparations, no effect can be extrapolated from a CH to another mixture. Thus, each orally administered CH preparation must be carefully analyzed in vitro and in vivo regarding pleiotropic effects before this peptide mixture can be attested to be an effective and safe nutraceutical for patients The distinct activities on OA cartilage are attributed to the differences of the peptide composition, and the extent to which a single oligopeptide or a combination of oligopeptides, aggregates, and metabolized peptides contributes in vivo to the major components of joint tissues remains to be determined In vivo studies Bagi (2017) [ 25 ] UC-II ® (InterHealth, Benicia, CA) Supported by Pfizer Consumer Healthcare 8 weeks Study results demonstrate that a clinically relevant daily dose of UC-II when applied immediately after injury can improve the mechanical function of the injured knee and prevent excessive deterioration of articular cartilage Better address joint functionality and impact of disuse and load bearing on cartilage metabolism, use of radiolabeled compound to assess metabolism and tissue distribution of UC-II and use of adequate immunological, histo-chemical and molecular methods to address some of the lingering questions regarding mechanism of action of “slow-acting” product such as UC-II Dai (2018) [ 45 ] NA (The authors, using Cartilage of Peru squid provided by Shanghai Fisheries (The authors Research Institute) Supported by grants from National Natural Science Foundation of China, and Shanghai Sci-Tech Committee Foundation 5 weeks These data suggested that the newly developed SCII could not only avoid the immunogenic risks of collagen derived from terrestrial animals, but more importantly, provide new choice for the control and treatment of OA NA Dai (2018) [ 26 ] NA (The authors, using cartilage of Peru squid provided by Shanghai Fisheries Research Institute) Supported by grants from National Natural Science Foundation of China, Shanghai Sci-Tech Committee Foundation-Pujiang Program, and National Key Research and Development Program of China 5 weeks Our findings show that SCII immunomodulates M2 activation of macrophages to skew the local OA microenvironment towards a pro-chondrogenic atmosphere, and promotes cartilage repair under inflammatory condition. It shows great potential for SCII to be a novel biomaterial for cartilage repair in OA NA Dar (2017) [ 46 ] Pepta...…”

“…Only two of these studies [ 25 , 47 ] evaluated undenatured collagen (UC), also known as native collagen. The other ten studies investigated collagen hydrolysate (CH); two of them used atelocollagen, administered by intra-articular injection [ 26 , 45 ]. The two studies on UC used different rat models of OA, different dosages of orally administered collagen (see Table 1 ), and measured different outcomes [ 25 , 47 ].…”

“…Types of Studies A total of 41 studies have been published on collagen derivatives in OA and cartilage repair so far. Sixteen of these studies were preclinical in vitro and in vivo studies [25,26,[41][42][43][44][45][46][47][48][49][50][51][52][53][54] and 25 were clinical studies (including clinical trials, observational studies, and systematic reviews/ meta-analyses) [27,28,31,. Figure 2 depicts the distribution of the studies by specific study type.…”

New-generation osteoplastic materials based on biological and synthetic matrices

“…Кроме того, коллаген, экстрагированный из ксеногенного матрикса, при недостаточно эффективной химической очистке демонстрирует выраженную имунногенность. У 20% пациентов, получивших имплантат из коллагеновой губки, обнаруживались антитела к коллагену I типа [114,124].…”