Squamous Lesions of the Ovary

Mahé, Etienne; Sur, Monalisa

doi:10.5858/arpa.2010-0640-rs

Cited by 12 publications

(13 citation statements)

References 17 publications

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“…It is often brittle, accompanied by bleeding and necrosis ( 32 ). SCC is the most common malignant transformation histology of MCTs ( 33 ). SCC-MCT shows a varied morphology, ranging from G1 and keratinizing to G3 to anaplastic ( 31 ).…”

Section: Discussionmentioning

confidence: 99%

30-Year Experience With 22 Cases of Malignant Transformation Arising From Ovarian Mature Cystic Teratoma: A Rare Disease

Qin

Shan

et al. 2022

Front. Oncol.

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ObjectiveTo investigate the clinical characteristics and survival outcomes of patients with malignant transformation arising from ovarian mature cystic teratoma (MT-MCT).MethodsThis retrospective study included patients with ovarian MCTs at Peking Union Medical College Hospital (PUMCH) during 1990.01-2020.12. When the pathologic histology was MT-MCT, detailed information was collected.ResultsOverall, 7229 ovarian MCT patients and 22 patients with MT-MCT were enrolled. The rate of malignant transformation of all ovarian MCTs was 0.30%. Most patients with MT-MCT were 51 (21–75) years old, and the tumor mass size was 10 (3–30) cm. The typical clinical symptoms were mainly abdominal pain and distension. The levels of tumor markers were elevated on preoperative examination. Early diagnosis could be made by ultrasonic examination, pelvic enhanced MRI and CT. Most patients underwent debulking surgery and adjuvant chemotherapy. The most common histological type to exhibit malignant transformation was squamous cell carcinoma (59.1%), followed by adenocarcinoma (13.6%), carcinoid (9.1%), and borderline tumor (18.2%). The 5-year RFS and OS rates were 54.5% and 81.8%, respectively. Patients with FIGO stage I had the best RFS (P=0.047) and OS (P=0.018), followed by those with FIGO stage II-IV.ConclusionMT-MCTs mainly occur in elderly females, are rare and have a poor prognosis. Advanced FIGO stage is a risk factor for survival. Although there is no standard treatment, cytoreductive debulking surgery and adjuvant chemotherapy could be considered. Perimenopausal and menopausal women with MCT should receive surgical treatment.

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Section: Discussionmentioning

confidence: 99%

30-Year Experience With 22 Cases of Malignant Transformation Arising From Ovarian Mature Cystic Teratoma: A Rare Disease

Qin

Shan

et al. 2022

Front. Oncol.

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“…Ovarian squamous lesions in women are often associated with teratomas, although it may be found as a metaplastic component in ovarian carcinomas or ovarian endometriosis [5,6]. To the best of our knowledge, squamous metaplasia of the rete ovarii has not been previously diagnosed in human medicine.…”

Section: Introductionmentioning

confidence: 99%

Squamous metaplasia of the rete ovarii in a Zebu cow

et al. 2012

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BackgroundStratified keratinizing squamous epithelium in the ovary has been associated with the diagnosis of ovarian teratoma in cows. Recently, the diagnosis of “epidermoid cyst” has been proposed. A case of squamous metaplasia of the rete ovarii in a Zebu cow is described in this report.Case presentationA crossbreed Zebu cow had both ovaries enlarged with multiple cysts. Most cysts were lined by well differentiated keratinizing stratified squamous epithelium and filled with keratinized lamellar material. Some cysts were lined by an epithelial layer that ranged from single cuboidal, double cuboidal epithelium, stratified non keratinized epithelium, and areas of keratinizing stratified squamous epithelium. Single or double layered cuboidal epithelia of the cysts expressed low molecular weight cytokeratin 7, whose expression was absent in the keratinizing stratified squamous epithelia of same cysts. Conversely, high molecular weight cytokeratins 1, 5, 10, and 14 were strongly expressed by the keratinizing stratified epithelium.ConclusionSquamous metaplasia of the rete ovarii was diagnosed. Squamous metaplasia of the rete ovarii, may account for some of the previously described squamous lesions in the ovary, which may have been misinterpreted as teratoma or epidermoid cysts.

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“…For all asymptomatic women, regardless of whether they are pre- or postmenopausal, a transvaginal ultrasound scan, as was used in this case, is preferred [ 2 ]. Dermoid cysts are fairly simple to recognize on pelvic imaging by the presence of bones or teeth [ 1 ]. However, in some cases, it is easy to confuse these findings with a complex hemorrhagic cyst.…”

Section: Discussionmentioning

confidence: 99%

“…Ovarian dermoid cysts, or mature cystic teratomas (MCT), are the most common benign ovarian tumor in adults and adolescents. They make up 70% of benign masses before menopause and 20% post-menopause [ 1 , 2 ]. They are characterized by adult ectodermal, mesodermal, and endodermal tissue and can contain skin, hair, teeth, fat and muscle, and even thyroid and brain tissue [ 1 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…They make up 70% of benign masses before menopause and 20% post-menopause [ 1 , 2 ]. They are characterized by adult ectodermal, mesodermal, and endodermal tissue and can contain skin, hair, teeth, fat and muscle, and even thyroid and brain tissue [ 1 , 3 ]. When an MCT contains primarily ectodermal tissue, it is described as a dermoid cyst [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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