Squamous intraepithelial lesions in HIV-infected women: prevalence, incidence, progression and regression

Kreitchmann, Régis; Bajotto, Halim Roberto; Silva, Daila Alena Raenck da

doi:10.1007/s00404-013-2871-3

Cited by 10 publications

(12 citation statements)

References 26 publications

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“…In Brazil, approximately 180,000 HIV-positive individuals are undergoing highly active antiretroviral therapy (HAART) administered by the Public Health System [6]. While this therapy has been associated with a substantial reduction in AIDS-related mortality, its role in preventing HPV infection and progression to CC is still poorly studied and controversial [6,7]. …”

Section: Resultsmentioning

confidence: 99%

Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian women

Rocha-Brischiliari

Gimenes

Abreu

et al. 2014

Infect Agents Cancer

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BackgroundHuman Papillomavirus (HPV) infection is particularly burdensome for women infected with human immunodeficiency virus (HIV), which increases their risk of developing cervical lesions and cancer (CC). We conducted a molecular study of the distribution of cervical HPV genotypes and the risk factors for this infection in HIV-infected Brazilian women.FindingsCervical and endocervical samples for Papanicolaou screening and HPV detection were collected from 178 HIV-infected women using highly active antiretroviral therapy (HAART) of Maringá city/Brazil. Risk factors were assessed using a standardized questionnaire, and the data regarding to HIV infection from medical records. HPV was detected by polymerase chain reaction (PCR), and genotyping using PCR-restriction fragment length polymorphism analysis. HIV infection was well controlled, but women with a current CD4+ T lymphocyte count between 200–350 cells/mm3 (37.6%) had a two-fold greater risk of HPV infection than those with > 350 cells/mm3 (26.4%). HPV was associated with parity ≥3, hormonal contraceptive use and current smoker. HPV infection occurred with high frequency (46.6%) but a low frequency of cervical abnormalities was detected (7.30%), mainly low-grade squamous intraephitelial cervical lesions (LSIL) (84.6%). A high frequency of multiple HPV infections was detected (23.0%), and the most frequent HPV genotype was HPV-72 (6.7%), followed by −16, -31 and -51 (6.14% each).ConclusionsWe showed that HAART use does not protect HIV-infected women from HPV, but appear to exert some protection against cervical lesions development. This study provides other important information about risk factors and cervical HPV in HIV-infected women, which can contribute to planning protocols.

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Section: Resultsmentioning

confidence: 99%

Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian women

Rocha-Brischiliari

Gimenes

Abreu

et al. 2014

Infect Agents Cancer

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“…The pattern of increasing relative risk with increasing degree of relatedness found in cervical cancer suggests that susceptibility to HPV-induced cancer is modulated by genetic factors (9). At the same time, the viral etiology of HPV-induced cancers implicates host immunity as a potential susceptibility factor (10), and the higher prevalence of cervical HPV infections, HPV-positive cervical cancer (11), and HPV-positive oropharyngeal cancer (12) in HIV/AIDS individuals suggests that the host immune response is an important determinant of HPV-induced cancer risk. Thus, we hypothesize that genetic variation in immune-related genes is a determinant of susceptibility to oropharyngeal cancer and other HPV-associated cancers.…”

Section: Introductionmentioning

confidence: 99%

TGFβ Receptor 1: An Immune Susceptibility Gene in HPV-Associated Cancer

et al. 2014

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Only a minority of those exposed to human papillomavirus (HPV) develop HPV-related cervical and oropharyngeal cancer. Because host immunity affects infection and progression to cancer, we tested the hypothesis that genetic variation in immune-related genes is a determinant of susceptibility to oropharyngeal cancer and other HPV-associated cancers by performing a multitier integrative computational analysis with oropharyngeal cancer data from a head and neck cancer genome-wide association study (GWAS). Independent analyses, including single-gene, gene-interconnectivity, protein–protein interaction, gene expression, and pathway analysis, identified immune genes and pathways significantly associated with oropharyngeal cancer. TGFβR1, which intersected all tiers of analysis and thus selected for validation, replicated significantly in the head and neck cancer GWAS limited to HPV-seropositive cases and an independent cervical cancer GWAS. The TGFβR1 containing p38–MAPK pathway was significantly associated with oropharyngeal cancer and cervical cancer, and TGFβR1 was overexpressed in oropharyngeal cancer, cervical cancer, and HPV+ head and neck cancer tumors. These concordant analyses implicate TGFβR1 signaling as a process dysregulated across HPV-related cancers. This study demonstrates that genetic variation in immune-related genes is associated with susceptibility to oropharyngeal cancer and implicates TGFβR1/TGFβ signaling in the development of both oropharyngeal cancer and cervical cancer. Better understanding of the immunogenetic basis of susceptibility to HPV-associated cancers may provide insight into host/virus interactions and immune processes dysregulated in the minority of HPV-exposed individuals who progress to cancer.

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“…Getinet et al (17) encontraram na Etiópia, em 197 pacientes HIV positivo, 82,2% de amostras negativas, 5,6% de ASCUS, 6,1% de LSIL, 5,1% de HSIL e 1,0% de carcinoma escamoso. Kreitchmann et al, (18) em Porto Alegre, encontraram amostras negativas em 82,5%, ASCUS em 6,2%, LSIL em 8,7%, HSIL em 2,4% e carcinoma invasor em 0,1%, valores semelhantes aos encontrados em nosso estudo, apenas com a diferença de terem encontrado carcinoma epidermoide.…”

Section: Discussionunclassified

“…Em nosso estudo, os resultados encontrados foram semelhantes aos encontrados por Getinet et al, (17) Chalermchockcharoenkit et al, (16) Silva et al, (13) Kreitchmann et al, (16) Brock (17) e Lemos et al (18) Apenas Camargo et al (21) obtiveram índices inferiores de positividade, com maior índice de LSIL e ASCUS em relação aos demais.…”

Section: Discussionunclassified

Precursor lesions of cervical cancer in HIV-positive women and their relationship with CD4+ and viral load Gaffrée and Guinle University Hospital

Maia¹,

Furtado²,

Carvalho³

et al. 2017

Revista Brasileira De Análises Clínicas

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Lesões precursoras do câncer uterino em mulheres HIV-positivo e sua relação com linfócitos CD4 + e carga viral do Hospital Universitário Gaffrée e Guinle -UNIRIO Precursor lesions of cervical cancer in HIV-positive women and their relationship with CD4 + and viral load Artigo Original/Original Article Resumo Objetivo: Associar as alterações citológicas do colo uterino com a carga viral e a contagem de CD4 + das pacientes portadoras do vírus HIV. Métodos: O estudo realizado foi transversal e prospectivo, sendo 112 mulheres examinadas, e o exame citológico foi colhido no HUGG e corado pela técnica de Papanicolaou na SITEC/ INCA. A carga viral e contagem de CD4 + foram retiradas dos prontuários das pacientes. Resultados: A frequência das alterações citológicas foi de 15,2%, sendo 7,1% de LSIL, 4,5% de ASCUS e 3,6% de HSIL. Pacientes com CD4 + menor que 200 células ou sem adesão ao tratamento apresentaram maior frequência de alterações citológicas; pacientes com CD4 + maior que 500 células e carga viral indetectável apresentaram menor frequência de alterações citológicas. Conclusão: Esses resultados demonstraram que houve maior frequência de alterações citológicas nas mulheres com menor contagem de CD4 + ou sem adesão ao tratamento, demonstrando uma maior associação de alterações citológicas nas mulheres com doenças que provocam imunossupressão e reforçando a importância do rastreamento do câncer de colo uterino nas mulheres HIV positivo. Palavras-chaveNeoplasias do colo do útero; HIV; Citodiagnóstico 1 Mestre em infecção HIV/AIDS e hepatites

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Squamous intraepithelial lesions in HIV-infected women: prevalence, incidence, progression and regression

Abstract: Prevalence and incidence of SIL in HIV-positive women were associated with severity of HIV disease. Interventions to increase access to Pap smears and further diagnostic tests should be implemented and targeted to HIV-positive women.

Cited by 10 publications

References 26 publications

Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian women

Risk factors for cervical HPV infection and genotypes distribution in HIV-infected South Brazilian women

TGFβ Receptor 1: An Immune Susceptibility Gene in HPV-Associated Cancer

Precursor lesions of cervical cancer in HIV-positive women and their relationship with CD4+ and viral load Gaffrée and Guinle University Hospital

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