Squamous-Cell Epithelioma That Simulates Sarcoma

Carcinosarcoma of the larynx.Case report with metastases of epidermoid and sarcomatous elements

“…T h e light microscopic appearance of our autopsy tumor and its metastases is similar to that of Grade IV squamous cell carcinomas of the skin as illustrated by Lever.11 These spindle-cell variants of squamous cell carcinoma have been specifically associated with radiodermatitis in the skin by Underwood et al and by Sins and Kirsch.17. 20 Radiation had always preceded the tumor by many years, however. These tumors are described as difficult to eradicate locally but of relatively benign nature as regards metastases.…”

Histologic Subtyping and Malignancy Assessment of Cutaneous Squamous Cell Carcinoma

“…47,50 The tumor, mostly occurring in males and especially in the elderly, is an ulcerated or exophytic mass that cannot be distinguished clinically from other SCC types. 47,[51][52][53] However, due to the lack of differentiation, the tumor may exhibit more aggressive characteristics with the increased likelihood of metastasis and recurrence. 50,52,54,55…”

Spindle Cell Squamous Cell Carcinoma Showing Continuous Mesenchymal Dedifferentiation in a Single Tumor

“…SCSCC developed in a renal transplant patient (3) and a patient with long‐standing erythoderma (4). The tumor preferentially occurs in the skin of elderly males and is clinically indistinguishable from other SCC types (5, 6). This poorly differentiated SCC of the skin displays elongated oval cells with hyperchromatic nuclei infiltrating into the dermis, sometimes following a whorl‐like pattern (7).…”