Carcinosarcoma of the larynx.Case report with metastases of epidermoid and sarcomatous elements

Abstract

Carcinosarcoma is a rare, controversial lesion reported in many organs including the larynx. This report describes an example of such a mixed tumor with metastases by both the sarcoma and the carcinoma from a laryngeal primary. Death resulted from progressive airway obstruction by recurrent polypoid sarcoma in the tracheal remnant 8 months after radiation and laryngectomy. Examination of the sarcomatous metastases with the electron microscope revealed large numbers of collagen fibers dispersed in a variety of directions immediately external to the plasma membrane of the tumor cells. An occasional malignant cell or group of cells was also surrounded by basal laminar material. One plasma membrane specialization similar to a junctional complex was present.

Spindle cell carcinoma of the gingiva: A rare occurrence

“…[1] SpCC has been referred to by a variety of names such as pseudosarcoma,[2] carcinosarcoma[3] and pleomorphic carcinoma, which reflects the divergent interpretations of the sarcomatoid component as reactive or neoplastic and mesenchymal or epithelial. There is a profound male to female predilection (11:1) and generally occurs in individuals in their seventh decade of life.…”

Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma

“…Proposed explanations of the bi-differentiated appearance include the multiclonal hypothesis on one hand, and on the other hand the "collision theory", suggesting that the two tumor components are derived from separate and distinct malignant cell clones [5,24] . Other investigators suggest a clonal origin (monoclonal hypothesis) of the tumor since common characteristics have been seen between the different cellular populations as well as an observed transitional population [25,26] .…”

“…Over the past 100 years, sarcomatoid carcinomas have been increasingly recognized at different anatomic locations including the head and neck, respiratory tract, and female reproductive organs [1][2][3] . Within the gastrointestinal tract, the oropharynx and esophagus are the most commonly affected areas [1,[4][5][6][7] . To our knowledge, sarcomatoid carcinomas rarely occur in the colon, with only nine cases reported in the English literature [8][9][10][11][12] .…”

Leukoplakia of buccal mucosa with transformation into spindle cell carcinoma: A rare case report

“…[2] SpCC, also called Lane tumor, pseudosarcoma, carcinosarcoma, sarcomatoid carcinoma, collision tumor and pleomorphic carcinoma, is an uncommon poorly differentiated type of SCC. [134] It is a biphasic tumor with a carcinoma that has surface epithelial changes and an underlying spindle-shaped neoplastic proliferation. [5] There has been confusion over the basic nature of the sarcomatoid element, that is, whether it is benign or malignant and mesenchymal or epithelial in origin.…”