Spindle cell carcinoma of the gingiva: A rare occurrence

Abstract

Of the many neoplasms known, squamous cell carcinoma (SCC) is the most common to affect the oral cavity. Spindle cell carcinoma (SpCC) is considered a rare high malignant variant of SCC occurring predominantly in the upper aerodigestive tract. Soft-tissue spindle cell neoplasms are quite uncommon in the oral cavity reportedly accounting for lesser than 1% of all tumors in the oral region. Our case shows an unusual presentation of SpCC involving the mandibular gingiva in a 46-year-old smoker patient, which presented as a firm, erythematous swelling with surface necrosis. An incisional biopsy was performed for microscopic evaluation to confirm the clinical diagnosis and for treatment planning.

Leukoplakia of buccal mucosa with transformation into spindle cell carcinoma: A rare case report

“…Double labeling with keratin and vimentin reflects the versatility of intermediate filament phenotype. [810] In the present case, there was positivity for both vimentin and cytokeratin.…”

“…[ 7 ] It commonly affects men than women, usually in the middle or later decades of life with a mean age of 57 years. [ 10 ] In the present case, the patient is a female in the third decade of life. Although the patient did not have any previous history of irradiation, there was known history of areca nut chewing.…”

Sarcomatoid squamous cell carcinoma of mandible: A report of two cases

“…[ 2 11 ] Alcohol, tobacco, poor oral health and radiation are considered to be the possible predisposing factors. [ 2 4 12 ] Other factors include genetic predisposition, injury and inflammation in patients. [ 13 ] In both our cases, the patients had significant history of tobacco chewing.…”

Unusual recurrent tongue spindle cell carcinoma with marked anaplasia occurring at the site of glossectomy for a well-differentiated squamous cell carcinoma: A case report

“…Another peculiar feature of the present case is that the patient had not received radiotherapy following the partial glossectomy. The occurrence of SpCC is associated with smoking, alcohol consumption, and radiation exposure ( 1 , 5 , 12 ), and instances of SpCC recurrence have been observed following radiotherapy for various primary malignancies, including SCC ( 9 , 11 , 13 ). Radiation is thought to induce EMT in various normal and neoplastic tissues ( 14 – 17 ).…”