Squamous cell carcinomas in situ arising in seborrheic keratoses: an association with concomitant immunosuppression?

Abstract

Immunocompromised patients with SKs appear to carry a greater risk of these otherwise innocuous lesions developing an SCCIS, although given the small number of patients evaluated, further research into this possible association is warranted.

Transformation of Seborrheic Keratosis into Bowenoid Actinic Keratosis via Three Steps of Histological Change in a Patient with Rheumatoid Arthritis Treated with Multiple Immunosuppressants

“…When a malignant cutaneous tumor arises within or in close proximity to SK, there has been a debate over whether the malignant tumor has actually originated from SK or instead represents a collision tumor. In previously reported cases of SK associated with SCC in situ, the region of SCC in situ has been seen on histopathological examination to be in direct contact with the SK region and most authors have considered that SK transforms directly to SCC in situ [1][2][3][4][5][6][7][8][9][10]. On the other hand, in the present case, we have observed two different histopathological regions between the main SK region and the region of bowenoid AK.…”

“…Our patient had been treated with several immunosuppressants before the AK lesion had developed, and immunosuppression has been reported as a risk factor for developing SCC in SK [8,10]. In addition, our patient showed no other AK lesions beyond that arising within the area of SK, whereas AK usually develops as multiple lesions.…”

“…Seborrheic keratosis (SK) has generally been considered a benign tumor, without any apparent potential for malignant transformation. On the other hand, although rare, cases of SK associated with squamous cell carcinoma (SCC) in situ arising within the SK have been reported [1][2][3][4][5][6][7][8][9][10]. Here, we describe a case of SK that transformed into bowenoid actinic keratosis (AK) via three steps of histological change in a 77-year-old woman.…”

Giant seborrheic keratosis of the face – an unusual presentation

“…Despite the benign nature of seborrheic keratosis, various authors have reported the concomitant cases of malignant skin tumours associated within these lesions [5,7,[12][13][14] . This may represent a probability of tumour collision rather than malignant transformation of the seborrheic keratosis; however, it cannot be excluded entirely.…”

“…The growth of the epidermal cells are arrested at the G1 phase, hence maintaining its biologically benign nature [1] . Various authors had reported a concomi-tant occurrence of malignant growth associated with seborrheic keratosis, although without strong association of it [4][5][6][7][8][9] . Unusually large-sized seborrheic keratoses are rarely reported, and their clinical significance is largely unknown.…”