Giant seborrheic keratosis of the face – an unusual presentation

Abstract

Seborrheic keratosis is the most common benign epidermal lesion in the world, especially among the elderly. Its inherent benign nature has precluded the need to remove it for medical reasons. Most of the concerns presented to dermatologists or plastic surgeons are of cosmetic reasons, besides some unusual appearances that necessitate cutaneous malignancy evaluation. Unusually large sizes of seborrheic keratosis are rarely reported, and its clinical significance is largely unknown. It has been proven by recent molecular studies that seborrheic keratosis is true neoplasia rather than a mere epidermal hyperplasia, and various authors have reported several cases of concomitant malignancy arising from seborrheic keratosis. Plastic surgeon expertise is often required when faced with an extensive lesion, requiring reconstructive procedures to preserve good aesthetic and functional outcomes. The purpose of this review is to report a case of an unusually large seborrheic keratosis on the face, highlighting its clinical relevance and surgical management.

Giant Seborrheic Keratosis on the Right Flank Part: A Case Report

“…Giant SK, an atypical SK, is rarely reported on the genitalia, perianal, or face in previous studies (14)(15)(16)(17). However, at the time of this study, no case of giant SK was reported on the flank part.…”

Perioral Clonal Variant of Seborrheic Keratosis: Diagnostic Challenges

“…The gene amyloid precursor protein (APP) expression was found to be expressed higher in the case of UV-exposed SK sites and in increased age groups [ 6 , 7 ]. SK also have acquired oncogenic mutations in tyrosine kinase/AKT-signaling cascades associated with hypersensitivity to AKT inhibition [ 8 ]. Results of recent studies suggest that seborrheic keratosis has a tendency for malignant transformation around 1.4 to 7%.…”