: The current standard of care in glioblastoma multiforme (GBM), as the most morbid brain tumor, is not adequate, despite substantial progress in cancer therapy. Among patients receiving current standard treatments, including surgery, irradiation, and chemotherapy, the overall survival (OS) period with GBM is less than one year. The high mortality frequency of GBM is due to its aggressive nature, including accelerated growth, deregulated apoptosis, and invasion into surrounding tissues. The understanding of the molecular pathogenesis of GBM is, therefore, crucial for identifying, designing, and repurposing potential agents in future therapeutic approaches. In recent decades, it has been apparent that several neurotransmitters, specifically substance P (SP), an undecapeptide in the family of neuropeptides tachykinins, are found in astrocytes. After binding to the neurokinin-1 receptor (NK-1R), the SP controls cancer cell growth, exerts antiapoptotic impacts, stimulates cell invasion/metastasis, and activates vascularization. Since SP/NK-1R signaling pathway is a growth driver in many cancers, this potential mechanism is proposed as an additional target for treating GBM. Following an evaluation of the function of both SP and its NK-1R inhibitors in neoplastic cells, we recommend a unique and promising approach for the treatment of patients with GBM.
Background: Today, information resources play of paramount importance role in providing information and public awareness. COVID-19 is a highly contagious disease and general precautions and identifying the factors influencing the self-care behaviors play an important role in the prevention of the disease. This study aimed to assess the relationship between trust in information resources and self-care behaviors in the prevention of COVID-19 disease on faculty members, staff, or students of Gonabad University of Medical Sciences between May and April 2020. Methods: This was an analytical cross-sectional study, conducted on 192 persons of faculty members, staff, or students of Gonabad University of Medical Sciences between May and April 2020. The sampling method was census We used a valid and reliable questionnaire to assess our goals. Data on demographic variables, information resources trust and self-care behaviors to them were collected using online self-administered questionnaires. Data were analyzed using SPSS software, using Chi-square and Pearson correlation test . Results: in this study of whom 60.2% were male. The mean age was 24.18±7.97 years (range of 18 to 59). The highest levels of trust in the information resources about COVID-19 were related to articles (37.8%) and faculty information (22.2%), and the lowest ones were related to national media (27.3%) and satellite channels (25.5%). The quality of self-care behavior in females was significantly higher than males (p = 0.018). There was no significant relationship between the level of trust in any of the information resources and the quality of self-care behaviors in the prevention of COVID-19 (p>0.05). Conclusions: According to the results of this study, there was no significant relationship between the level of trust in information resources and the quality of self-care behaviors to prevent COVID-19and further investigations are needed to find possible associated factors.
Background: Recently, there has been a global demand toward finding new treatments to control the new pandemic of coronavirus (COVID-19). The aim of this systematic review was to study the effects of ozone therapy on COVID-19 patients, as well as reviewing the available supporting evidence. Methods: Electronic databases including MEDLINE (via PubMed), EMBASE, Cochrane Library (CENTRAL), and TRIP, as well as clinical trial registries and preprint sources were searched for published evidence-based articles. In addition, a hand searching was conducted regarding the attained articles published until 6 April 2020 using MeSH and free text keywords with no language limitation. Articles were screened, categorized and extracted for the relative data, which are reported in a descriptive manner. Results: Among 234 articles, 9 were selected to be reviewed for the inclusion criteria. No previously published original articles were found on the efficacy of ozone therapy on COVID-19. Five review studies on the potential role of systemic ozone therapy were found, in which it was concluded that ozone therapy is effective in controlling COVID-19 due to its antiviral, oxygenating, anti-inflammatory, oxidation balancing and immunomodulation effects. Three ongoing clinical trials were registered in China. Moreover, a preliminary report of an ongoing study in Italy on 46 patients (11 intubated and 35 non-intubated) indicated that 39 patients (84%) showed an improvement for the symptoms of the disease. Conclusion: Despite the promising hypothetical background, opinions of the expert arguing about the benefits of this method, and a preliminary report indicating the effectiveness of ozone therapy as a novel treatment option for COVID-19, there is still not enough evidence to prove it. Hosted file Revised Ozone therapy.docx available at https://authorea.com/users/315183/articles/446123-usingozone-therapy-as-an-option-for-treatment-of-covid-19-patients-a-scoping-review
Background: Irritable bowel syndrome (IBS) is a highly prevalent disorder of the gut interaction characterized by abdominal discomfort and pain associated with altered bowel habits in the absence of structural abnormalities. In spite of IBS' high prevalence and disease burden across the globe, no explanations have been given as to its underlying pathophysiology. As for the treatment of IBS, there is no specific medication, and the most beneficial treatment is usually supportive therapy. Recent animal and human studies have demonstrated the therapeutic potential of curcumin or turmeric in the treatment of IBS. Methods: We systematically reviewed all available evidence supporting curcumin and turmeric's therapeutic potential in relieving IBS symptoms in the present study. For this purpose, a database search was performed using curcumin, turmeric, and IBS and all their equivalents as of the search terms in Web of Science, PubMed, Scopus, Ovid, Embase, and Google Scholar from1990 up to Feb 2021. The investigation was then limited to clinical trials, and then nine articles were collected for data analysis. Results: The findings of the included literature showed that curcumin and turmeric alone or in combination with other medications could improve the severity of IBS as well as the quality of life among people who suffer from IBS symptoms. Conclusion: Overall, medications containing curcumin and turmeric extract due to these compounds' anti-inflammatory effects may improve IBS symptoms, particularly abdominal pain and life quality.
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