Squamous-Cell Carcinoma of the Upper Lip - Analysis of 123 Cases

Calabrese, L; Ionna, Franco; Tradati, Nicoletta; Pizzi, Natalia; Mattavelli, Franco; Greco, Maria Raffaella; Zurrida, Stefano; Cantù, G.

doi:10.3892/ijo.3.4.667

Cited by 2 publications

(5 citation statements)

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“…Unlike previous descriptive studies, [ 2 , 5 ] we observed no local recurrence or distant metastasis. An important explanation for this is that tumor-free resection margins were achieved in all patients, and various reconstructive procedures were available no matter how great the defect was.…”

Section: Discussioncontrasting

confidence: 99%

“…Parotid node metastasis occurred in 2 patients, and although the incidence was low, similar to previous findings, [ 2 , 3 ] it must be considered during the differential diagnosis of parotid tumors. Both of these patients underwent total parotidectomy and postoperative radiotherapy, and neither patient died of the disease in our follow up.…”

Section: Discussionsupporting

confidence: 87%

“…Due to the rare incidence of upper lip SCC, the existing literature was usually descriptive. Calabrese et al [ 2 ] only reported high frequency of early relapses and the importance of regular and careful follow-up without an evaluation of the risk factors affecting regional recurrence. Another study [ 4 ] focused on the demographic data, clinicopathologic features and therapeutic outcome of a series of upper lip malignancies, and the authors concluded that there were some differences regarding the etiology of pathologic type and in survival with respect to those found in the lower lip.…”

Section: Discussionmentioning

confidence: 99%

“…Although upper lip SCC usually has a good prognosis, consistent disease-related death is observed. [ 2 – 8 ] A number of variables, including tumor stage, perineural invasion, tumor subsite, and differentiation extent, have been described as being associated with the chance of mortality in head and neck SCC. [ 9 , 10 ] It is widely accepted that lymphatic metastasis is the most important factor in determining prognosis, and the survival rate can be reduced by 50% if there are cervical positive pathological nodes found at diagnosis.…”

Section: Introductionmentioning

confidence: 99%

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Management of and risk factors for regional recurrence in upper lip squamous cell carcinoma

Liu¹,

Wang

Pang

et al. 2017

Medicine

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Our goal was to evaluate the risk factors for regional recurrence in upper lip squamous cell carcinoma (SCC).A total of 109 patients with upper lip SCC were retrospectively enrolled. Clinical and pathologic information was collected and analyzed.Fifteen (13.8%) patients had a regional metastasis, 2 patients had parotid node metastasis, and no local or distant metastasis was noted. There was neck level I node metastasis in 15 (100%) patients. In multivariate analysis, invasion depth and degree of differentiation were significantly associated with regional metastasis. The 5- and 10-year disease-specific survival rate was 95.4% and 80.1%, respectively.Invasion depth and degree of differentiation have reliable value for predicting regional metastasis.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Management of and risk factors for regional recurrence in upper lip squamous cell carcinoma

Liu¹,

Wang

Pang

et al. 2017

Medicine

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“…Topical treatments include applications of 5-fluorouracil, imiquimod, and 3% Diclofenac in 2.5% hyaluronic acid ( 45 – 47 ). One of the classical approaches for the management of lip SCC is considered to be surgical excision ( 3 – 5 , 48 ). In the present case report, we opted for surgical excision via vermilionectomy, given the fact that it provides a safe, quick, and economically efficient therapeutic option, particularly in the case of lower lip SCC.…”

Section: Discussionmentioning

confidence: 99%

Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip

Lupu

Căruntu

et al. 2018

mol clin onc

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An early diagnosis is of overwhelming importance for the management and prognosis of mucocutaneous cancer. Actinic cheilitis (AC), defined by the clonal expansion of genomically unstable keratinocytes, is the most common potentially malignant lesion affecting the lips. Squamous cell carcinoma (SCC) is the most frequent oral malignancy, and there is strong evidence that the majority of the SCCs of the lip originate from AC. There is considerable difficulty in discerning between dysplasia and invasive carcinomas solely on a clinical basis. Although dermoscopy has become an essential tool for skin tumor evaluation, reflectance confocal microscopy (RCM) is a non-invasive imaging technology that has proved itself extremely useful in the diagnosis and monitoring of several skin diseases, including AC and SCC. The present study aimed to re-emphasize the usefulness of RCM in the early detection of malignant transformation, using AC and SCC of the lips as working examples. Due to the apparent innocuousness of AC for numerous patients, it is not possible to overstress the importance of a correct and early diagnosis, proper treatment and long-term patient follow-up as being essential for preventing the progression to lip SCC, or for its timely diagnosis.

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Squamous-Cell Carcinoma of the Upper Lip - Analysis of 123 Cases

Cited by 2 publications

References 0 publications

Management of and risk factors for regional recurrence in upper lip squamous cell carcinoma

Management of and risk factors for regional recurrence in upper lip squamous cell carcinoma

Non-invasive imaging of actinic cheilitis and squamous cell carcinoma of the lip

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