Squamous cell carcinoma of the extrahepatic bile duct with metachronous para-aortic lymph node metastasis successfully treated with S-1 plus cisplatin

Abstract

The most common histological classification of bile duct cancer is adenocarcinoma and squamous cell carcinoma (SCC) is relatively rare. We report a case of a 78-year-old man with SCC of the extrahepatic bile duct associated with metachronous para-aortic lymph node metastasis. He had undergone subtotal stomach-preserving pancreatoduodenectomy. The pathological findings demonstrated moderately differentiated SCC of the distal extrahepatic bile duct (T1N1M0, stage IIB). 6 months after surgery, recurrence of the para-aortic lymph node was shown in abdominal CT. 5 courses of tegafur/gimeracil/oteracil (S-1) plus cisplatin therapy was performed and the para-aortic lymph node disappeared, confirmed as complete response by imaging findings. The patient is alive without recurrence, 10 months after recurrence and chemotherapy.

Squamous cell carcinoma of the common bile duct: A case report with genomic profiling

“…To date, only 17 cases of pure SCC‐EBD have been reported, including this present case. Several of these reports include literature reviews …”

“…Recent data indicate that tumors harboring FBXW7 could benefit from mTOR kinase inhibitors . Although squamous cell carcinoma of the extrahepatic bile ducts is a rare entity, increased knowledge on these tumors could benefit these patients, as the disease is often advanced at the time of diagnosis with no established chemotherapy or radiation therapy regimens …”

“…Several of these reports include literature reviews. 2,4 The etiology of SCC-EBD is essentially unknown. Four main theories have been proposed: (i) derivation from ectopic squamous epithelium; (ii) derivation from undifferentiated basal cells; (iii) transformation of adenocarcinoma; and (iv) derivation from metaplastic squamous epithelium due to inflammatory irritation of the biliary mucosa.…”

“…Squamous cell carcinoma (SCC) of the extrahepatic bile ducts (SCC‐EBD) is a rare entity. Since 1930, only 17 cases including the case presented here have been reported . The etiology is essentially unknown and with the small number of cases a plausible pathogenesis has been difficult to establish.…”

“…Since 1930, only 17 cases including the case presented here have been reported. [1][2][3][4] The etiology is essentially unknown and with the small number of cases a plausible pathogenesis has been difficult to establish.…”