Extrahepatic biliary obstruction due to bile duct metastasis from primary esophageal squamous cell carcinoma: a rare cause of jaundice

Rana, Surinder Singh; Kapoor, Rakesh; Gupta, Parikshaa; Gupta, Rajesh

doi:10.20524/aog.2019.0397

Cited by 3 publications

(2 citation statements)

References 2 publications

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“…Endoscopic retrograde cholangiopancreatography, intraductal ultrasonography, or spy glass are valuable for the biopsy of extrahepatic lesions[ 14 ]. Even if SCC of the bile duct has been confirmed, gastroenteroscopy and positron emission tomography-CT are still necessary in view of reports of biliary metastasis of esophageal SCC[ 21 , 22 ]. The immunohistochemistry results vary widely among differentiated cases.…”

Section: Discussionmentioning

confidence: 99%

Rare primary squamous cell carcinoma of the intrahepatic bile duct: A case report and review of literature

Ma,

Wang,

Yang

et al. 2024

World J Clin Oncol

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BACKGROUND Cholangiocarcinoma is the most common malignancy of the biliary tree and has a poor prognosis. Adenocarcinoma is the most common pathological type of cholangiocarcinomas, but rare squamous, adenosquamous, and mucinous variants have been reported without adequate clinical data. CASE SUMMARY This report describes a rare case of primary squamous cell carcinoma (SCC) of the intrahepatic bile duct. The patient was admitted with a tumor in the hepatic caudate lobe with no obvious clinical symptoms. Examination revealed hepatitis B surface antigen positivity, a slight increase in alfa-fetoprotein to 16.34 ng/mL, and an irregular slightly heterogeneous enhancing lesion in the hepatic caudate lobe, which was initially thought to be hepatocellular carcinoma. Laparoscopic resection was performed, and the final pathology suggested a rare primary SCC of the intrahepatic bile duct. Immunohistochemistry indicated positivity for villin, partial positivity for p63, and negativity for hepatocyte, CK7, CK8, CK19, and CK20. The Ki-67 index was approximately 60%. The patient received six cycles of Tegio chemotherapy. A new lesion was detected in the liver after 15 months. The surgery was performed, and the patient was followed-up at a local hospital. To date, no new lesions have been observed. CONCLUSION Surgery is the first choice for resectable lesions, and combined chemotherapy based on pathology is essential for increasing overall survival.

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Section: Discussionmentioning

confidence: 99%

Rare primary squamous cell carcinoma of the intrahepatic bile duct: A case report and review of literature

Ma,

Wang,

Yang

et al. 2024

World J Clin Oncol

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“…Esophageal carcinoma tends to spread locally, to the regional lymph nodes (paraesophageal or celiac lymph nodes), and finally to distant organs. It is usually diagnosed in its late stages as the lumen of the esophagus progressively narrows causing dysphagia and unwanted weight loss 6 . Although it is known to spread to the celiac lymph nodes, to the best of our knowledge and search of the literature, there has never been a published case of esophageal squamous carcinoma presenting with a dilated gallbladder and obstructive jaundice, mimicking Courvoisier's Law.…”

Section: Discussionmentioning

confidence: 99%

Extrahepatic biliary obstruction secondary to metastatic esophageal squamous cell carcinoma: An unusual presentation of Courvoisier's law

Atiba¹,

Ramdass²,

Oladiran³

et al. 2021

Clinical Case Reports

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Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

Okamoto¹

2022

WJG

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Malignant biliary obstruction generally results from primary malignancies of the pancreatic head, bile duct, gallbladder, liver, and ampulla of Vater. Metastatic lesions from other primaries to these organs or nearby lymph nodes are rarer causes of biliary obstruction. The most common primaries include renal cancer, lung cancer, gastric cancer, colorectal cancer, breast cancer, lymphoma, and melanoma. They may be difficult to differentiate from primary hepato-pancreato-biliary cancer based on imaging studies, or even on biopsy. There is also no consensus on the optimal method of treatment, including the feasibility and effectiveness of endoscopic intervention or surgery. A thorough review of the literature on pancreato-biliary metastases and malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer is presented. The diagnostic modality and clinical characteristics may differ significantly depending on the type of primary cancer. Different primaries also cause malignant biliary obstruction in different ways, including direct invasion, pancreatic or biliary metastasis, hilar lymph node metastasis, liver metastasis, and peritoneal carcinomatosis. Metastasectomy may hold promise for some types of pancreato-biliary metastases. This review aims to elucidate the current knowledge in this area, which has received sparse attention in the past. The aging population, advances in diagnostic imaging, and improved treatment options may lead to an increase in these rare occurrences going forward.

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Extrahepatic biliary obstruction due to bile duct metastasis from primary esophageal squamous cell carcinoma: a rare cause of jaundice

Cited by 3 publications

References 2 publications

Rare primary squamous cell carcinoma of the intrahepatic bile duct: A case report and review of literature

Rare primary squamous cell carcinoma of the intrahepatic bile duct: A case report and review of literature

Extrahepatic biliary obstruction secondary to metastatic esophageal squamous cell carcinoma: An unusual presentation of Courvoisier's law

Malignant biliary obstruction due to metastatic non-hepato-pancreato-biliary cancer

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