Squamous cell carcinoma of the oral tongue: Distinct epidemiological profile disease

Yosefof, Eyal; Hilly, Ohad; Stern, Sagit; Bachar, Gideon; Shpitzer, Thomas; Mizrachi, Aviram

doi:10.1002/hed.26177

Cited by 18 publications

(17 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Head and neck squamous cell carcinoma (HNSCC) is accounting for approximately 6% of all cancer cases, and it is the 6 th most common malignancy worldwide, responsible for an estimated 1%–2% of all cancer death (Ezhilarasan et al., 2019; Ralli et al., 2020). Oral squamous cell carcinoma (OSCC) occurs in different subsites within the oral cavity and accounts for about 90% of malignant oral lesions (Yosefof et al., 2020). Collectively, oral cancer is one of the most leading cancer responsible for significant morbidity and mortality in the Indian sub‐continent (Sharma et al., 2018; Zhou et al., 2017).…”

Section: Introductionmentioning

confidence: 99%

The ambiguous role of sirtuins in head and neck squamous cell carcinoma

et al. 2021

View full text Add to dashboard Cite

Oral cancer is one of the most leading cancer responsible for significant morbidity and mortality. The sirtuins (SIRTs) are a family of class III histone deacetylases and are known to regulate a variety of molecular signaling associated with different cancer types including oral malignancies. SIRT1 acts as bifunctional in a variety of cancer. In oral cancer, SIRT1 seems to work as a tumor suppressor. The carcinogenic potential of SIRT1 is also reported in oral cancer, and hence, its role is still ambiguous.SIRT2 is also said to play a dual-faced role in different types of cancers. However, in oral cancer, SIRT2 is not studied and its role remains obscure. SIRT3 expression was positively correlated with oral malignancies. However, studies also showed the anticancer role of SIRT3 in oral cancer. SIRT7 loss was observed in oral cancer cells, while its overexpression caused the suppression of oral cancer cells proliferation, migration, and invasiveness. The role of other SIRTs in oral cancer was studied meagerly or reports not available. To date, only the roles of SIRT1, SIRT3, and SIRT7 have been reported in oral malignancies. Therefore, understanding the regulatory mechanisms employed by sirtuins to modulate oral cancer is important for developing potential anti-cancer therapeutic strategies.

show abstract

Section: Introductionmentioning

confidence: 99%

The ambiguous role of sirtuins in head and neck squamous cell carcinoma

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Head and neck cancers (HNCs) are a group of heterogeneous diseases with multifocal and multicellular origins, which occur in the nasal sinuses, nasal cavity, oral cavity, pharynx, throat, salivary glands, thyroid gland, etc. Squamous cell carcinomas comprise 90% of cases and are called head and neck squamous cell carcinoma (HNSCC) [ 1 ]. HNSCC, as the most common cancer type of the head and neck, is the sixth most common cancer worldwide, accounting for almost 5% of all malignant tumors [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Prognostic Markers for Head and NeckSquamous Cell Carcinoma Based on Glycolysis-Related Genes

Ren

Song

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Head and neck squamous cell carcinomas (HNSCCs) comprise a heterogeneous group of tumors. Many patients respond differently to treatment and prognosis due to molecular heterogeneity. There is an urgent need to identify novel biomarkers to predict the prognosis of patients with HNSCC. Glycolysis has an important influence on the progress of HNSCC. Therefore, we investigated the prognostic significance of glycolysis-related genes in HNSCC. Our results showed that ELF3, AURKA, and ADH7 of 20 glycolysis-related DEGs were significantly related to survival and were used to construct the risk signature. The risk score showed high accuracy in distinguishing the overall survival (OS) of HNSCC. The Kaplan–Meier curves demonstrated that the risk score was associated with an unfavorable prognosis in patients with female sex, male sex, grade 3, T1/2 stage, N+ stage, N2 stage, M0 stage, and clinical stage III/IV. Independent prognostic analysis showed that clinical stage and risk score were strongly associated with OS. Moreover, the risk score had higher accuracy in predicting 1-, 3-, and 5-year survival. AURKA and ADH7 were only significantly related to M1 macrophages and neutrophils, respectively, while ELF3 was significantly correlated with M2 macrophages and monocytes (all p < 0.05 ).The ceRNA network demonstrated that miR-335-5p and miR-9-5p may play core roles in the regulation of these three genes in HNSCC. The risk score constructed based on three glycolysis-related genes showed high accuracy in predicting the prognosis and clinicopathological characteristics of HNSCC.

show abstract

“…Tongue squamous cell carcinoma (TSCC) is the most common head and neck cancer [2]. Tobacco and alcohol consumption are the two major risk factors of TSCC [3].…”

Section: Introductionmentioning

confidence: 99%

Synergistic Cytotoxic Effect of Honey Bee Venom and Cisplatin on Tongue Squamous Cell Carcinoma Cell Line

Amar¹,

Elbolok

Elgayar

et al. 2021

Open Access Maced J Med Sci

View full text Add to dashboard Cite

BACKGROUND: Tongue cancer is one of the most common head and neck cancers in the world. Nowadays, natural compounds are important resources of many anti-cancer drugs. Venom from honey bees possesses potent anti-cancer activities. Cisplatin is a chemotherapeutic drug that has been used for decades to treat cancer cells. Recently, combination therapy has been a popular treatment choice for cancer patients. AIM: This study was conducted to evaluate the synergistic cytotoxic effect of honey bee venom (BV) and cisplatin on tongue squamous cell carcinoma 25 (SCC-25) cell lines. METHODS: The cytotoxic effect was determined using methyl thiazol tetrazolium assay, microscopic examination, real-time polymerase chain reaction (RT-PCR), and statistical analysis. RESULTS: The findings revealed that the cytotoxic potential of the tested drugs on SCC-25 cells was dose-dependent. Microscopic examination showed that BV and cisplatin alone and in combination mainly produced apoptotic cell death. Regarding RT-PCR results, P53 and caspase-3 expression levels were significantly increased in SCC-25-treated cells (p = 0.0001). CONCLUSION: The combined use of BV and cisplatin induced a marked synergistic cytotoxic effect on SCC-25 cell line.

show abstract

Squamous cell carcinoma of the oral tongue: Distinct epidemiological profile disease

Cited by 18 publications

References 22 publications

The ambiguous role of sirtuins in head and neck squamous cell carcinoma

The ambiguous role of sirtuins in head and neck squamous cell carcinoma

Identification of Prognostic Markers for Head and NeckSquamous Cell Carcinoma Based on Glycolysis-Related Genes

Synergistic Cytotoxic Effect of Honey Bee Venom and Cisplatin on Tongue Squamous Cell Carcinoma Cell Line

Contact Info

Product

Resources

About