Squamous cell carcinoma of the vulva arising in the setting of chronic hidradenitis suppurativa: A case report

Abstract

HighlightsHighlights the sheer mass of tumor encountered with hidradenitis suppurativa.Reviews the complexity of wound healing with hidradenitis suppurativa.Overview of multi-team approach to a vulvar cancer.

Cutaneous Squamous Cell Carcinoma in Patients with Hidradenitis Suppurativa

“…All the case reports and series met the minimum quality assessment standard and were included in the meta-analysis ( Supplementary Table S1 ) [ 2 , 6 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Selection bias cannot be excluded as most authors did not explicitly explain their selection method; therefore, there is a possibility that some cases of cSCC arising from HS wounds were not reported, underestimating the total number of cases currently in the literature.…”

Vulvar squamous cell carcinoma complicating hidradenitis suppurativa in a young woman

“…In the literature, we identified 7 cases of vulvar SCC in patients with HS (Table I). 7, 8, 9, 10 Among these cases, the mean duration of HS before the SCC was 25 years. In our patient, symptoms were present for 18 years, but the diagnosis of HS was not established.…”

“…This delay can explain why metastatic evolution is frequent: 55.1% of patients in Jourabchi's study 1 Table IReports of vulvar squamous cell carcinoma in patients with HSStudyAge (y)History of HS (y)LocationMetastasisYes/NoTreatmentOutcomeMakris et al, 2017 7 432VulvaNSurgeryAlive 1 year after surgeryRekawek et al, 2016 8 61—Left labiaNSurgeryNot reportedPeña et al, 2015 9 6444Right labiaYRadiotherapy and chemotherapyAlive after 19 mo with signs of progressive diseaseMaclean and Coleman, 2007 10 6140Right vulvaYPalliative radiotherapyDied 2 mo after diagnosisCrain, 2005 (cited in Peña et al 9 )4420Right labiaYPalliative radiotherapyDied 6 mo after diagnosisShort, 2005 (cited in Peña et al 9 )5715Right labia minoraNSurgeryNot reportedManolitsas, 1999 (cited in Peña et al 9 )5230Right vulvaNSurgeryNot reported…”

Neoplastic Implications in Patients Suffering from Hidradenitis Suppurativa under Systemic Treatments

“…The presence of sinus tracts in HS provides an easy route for dissemination of malignant cells, and the detection of malignant transformation may be difficult on the background of chronic tissue inflammation [ 53 ]. Furthermore, cases of SCC arising at the vulvar region [ 14 , 29 , 33 , 48 ], as well as perianal and perineal in women with a long history of the disease are not rare; difficulties in recognition may lead to delay in diagnosis [ 68 ]. The literature suggests that the local invasive recurrence rate for primary tumors (T1) is 7.2% after radical local excision compared with 6.3% after radical vulvectomy.…”

“…Many authors have advocated that HS arising in extra-axillary sites be regarded as a pre-malignant condition and not to be treated conservatively. Close follow-up and repeated skin biopsies should be performed in those with suspected malignancy [ 48 ]. The review of pertinent literature also revealed anecdotical cases of tumours other than SCC arisen on HS lesions or SCCs developing in the setting of syndromic conditions.…”