Vulvar squamous cell carcinoma complicating hidradenitis suppurativa in a young woman

Vulvar cancer in hidradenitis suppurativa

“…Even though it is rare, there are several previously published case reports on women with SCC in an area of HS. Some of them describe patients with only stage 1 vulvar cancer with good outcome after surgery alone without adjuvant treatment ( Rekawek et al, 2016 , Sevray et al, 2019 , Janse et al, 2017 ), however in line with the two cases in this current article there are several publications describing a more aggressive course and a high frequency of metastases at presentation. A review of literature on SCC in HS in 2010 found that almost half of the 38 patients developed lymph node metastases during follow-up compared to only 5–10% of patients with a SCC of the skin of any etiology ( Lavogiez et al, 2010 ).…”

Cutaneous Squamous Cell Carcinoma in Patients with Hidradenitis Suppurativa

“…All the case reports and series met the minimum quality assessment standard and were included in the meta-analysis ( Supplementary Table S1 ) [ 2 , 6 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Selection bias cannot be excluded as most authors did not explicitly explain their selection method; therefore, there is a possibility that some cases of cSCC arising from HS wounds were not reported, underestimating the total number of cases currently in the literature.…”

“…Rarely, patients presented with vulvar, scrotal, scapular, inguinal, and axillary cSCC. In studies where smoking history was obtained, 81.5% (22/27 patients) were active or past smokers [ 2 , 6 , 18 , 19 , 25 , 28 , 35 , 36 , 37 , 40 ].…”

“…Ten studies (36 patients) investigated the presence of HPV by either DNA and RNA in situ hybridization, polymerase chain reaction (PCR) or p16 staining on paraffin-embedded tumor specimens [ 2 , 6 , 15 , 17 , 18 , 19 , 20 , 25 , 35 , 36 ]; HPV was detected in 10 of these patients. In 2 additional patients, HPV infection was confirmed visually given the presence of condyloma acuminata and vulvar intraepithelial neoplasia [ 42 , 43 ].…”

“…Distant metastases were found in 31 patients (31.3%), mainly in the lungs. Tumor node metastasis (TNM) staging was directly reported for only 12 patients from 5 studies [ 6 , 15 , 22 , 25 , 36 ]. In total, 100/131 patients (76.3%) had undergone surgical excision of the tumor, 37/50 patients (74%) received radiotherapy, and 26/43 (60.5%) received polychemotherapy.…”