Squamous cell carcinoma of the penis and scrotum in a patient with chronic scrotal and penile lymphedema

Abhyankar, Suhas V; Kulkarni, Ananta A; Kulkarni, Madhuri; Agarwal, Naveen

doi:10.4103/0019-5154.74563

Cited by 11 publications

(5 citation statements)

References 6 publications

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“…Other uncommon occurrences of SCC on pre-existing dermatological conditions, which have been reported from India include the following: lichen planus (LP)[ 44 ] including LP hypertrophicus,[ 45 ] necrobiosis lipoidica diabeticorum (NLD),[ 46 ] lichen simplex chronicus (LSC),[ 47 ] psoriasis,[ 48 ] chronic lymphedema,[ 49 ] and disseminated porokeratosis. [ 50 ] Various pathogenetic factors have been ascribed to the malignant transformation in these conditions, inter alia , hypoxic status of poorly vascularized cicatricial structures in NLD, chronically irritated skin of LSC, deficiency in afferent lymphatic drainage preventing early recognition of tumor-specific antigen in chronic lymphedema,[ 51 ] and overexpression of p53 in the keratinocytes near the cornoid lamella in the porokeratotic lesion.…”

Section: Clinical Aspectsmentioning

confidence: 99%

Nonmelanoma skin cancer in India: Current scenario

Panda

2010

Indian J Dermatol

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Incidence of skin cancers has been increasing since the last few decades worldwide. Nonmelanoma skin cancer (NMSC) is the commonest variety of cutaneous malignancy. Conventional wisdom has it that the incidence of all varieties of skin cancers is lower among Indians due to the protective effects of melanin. Though national surveys and cross-country data in India are unavailable, there are indirect indications from several smaller reports that NMSCs may be on the rise in India. Reports of quite a few atypical cases lead us to hypothesize that factors other than ultraviolet radiation may be important in the occurrences of these cancers, particularly in the skin types prevalent in India. The descriptive epidemiology and clinical characteristics of squamous and basal cell carcinoma in India, including their variants, are discussed here along with hypotheses on their etiopathogenesis. Novel management techniques currently available in India are also highlighted.

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Section: Clinical Aspectsmentioning

confidence: 99%

Nonmelanoma skin cancer in India: Current scenario

Panda

2010

Indian J Dermatol

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“…Chronic stasis in lymphedema results in alterations in lymphatic protein composition, notably a decrease in the alpha-2 globulin fraction and an increased albumin-globulin ratio. These changes delay protein transportation from the interstitial space to the lymphatic tissue, affecting the tissue's antigenic composition and regional immunological competence [ [10] , [11] , [12] ]. In rare instances, chronic lymphedema can evolve into squamous cell carcinoma, with fewer than 20 cases documented in literature and merely 11 of these involving the lower limbs.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of skin in a case of post-filariasis chronic lower limb lymphedema- a case study and review of literature

Mangla,

Singh,

Goel

2024

International Journal of Surgery Case Reports

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“…SCC has rarely been found to be associated with chronic lymphedema. So far, 4 congenital cases and 9 acquired cases, all arising in the extremities [ 7 , 8 ], as well as 3 cases with penoscrotal involvement [ 9 , 10 , 11 ], have been reported. To the best of our knowledge, this study is the first to report involvement of the labia.…”

Section: Discussionmentioning

confidence: 99%

Labia Majora Share

et al. 2017

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Defects involving specialised areas with characteristic anatomical features, such as the nipple, upper eyelid, and lip, benefit greatly from the use of sharing procedures. The vulva, a complex 3-dimensional structure, can also be reconstructed through a sharing procedure drawing upon the contralateral vulva. In this report, we present the interesting case of a patient with chronic, massive, localised lymphedema of her left labia majora that was resected in 2011. Five years later, she presented with squamous cell carcinoma over the left vulva region, which is rarely associated with chronic lymphedema. To the best of our knowledge, our management of the radical vulvectomy defect with a labia majora sharing procedure is novel and has not been previously described. The labia major flap presented in this report is a shared flap; that is, a transposition flap based on the dorsal clitoral artery, which has consistent vascular anatomy, making this flap durable and reliable. This procedure epitomises the principle of replacing like with like, does not interfere with leg movement or patient positioning, has minimal donor site morbidity, and preserves other locoregional flap options for future reconstruction. One limitation is the need for a lax contralateral vulva. This labia majora sharing procedure is a viable option in carefully selected patients.

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Squamous cell carcinoma of the penis and scrotum in a patient with chronic scrotal and penile lymphedema

Cited by 11 publications

References 6 publications

Nonmelanoma skin cancer in India: Current scenario

Nonmelanoma skin cancer in India: Current scenario

Squamous cell carcinoma of skin in a case of post-filariasis chronic lower limb lymphedema- a case study and review of literature

Labia Majora Share

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