Nonmelanoma skin cancer in India: Current scenario

Panda, Saumya

doi:10.4103/0019-5154.74551

Cited by 53 publications

(30 citation statements)

References 56 publications

(58 reference statements)

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“…Nevertheless, a recent Indian review showed that there are indirect indications that NMSCs may be on the rise in India. [49] Unlike NMSC, the direct association with UV exposure is still under investigation for cutaneous malignant melanoma. Severe sunburn episodes during childhood may cause the development of melanoma on sun-exposed areas.…”

Section: Pigmentationmentioning

confidence: 99%

Cutaneous solar ultraviolet exposure and clinical aspects of photodamage

Battie¹,

Verschoore²

2012

Indian J Dermatol Venereol Leprol

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Solar ultraviolet (UV) radiation reaching the earth is a combination of UVB (290-320 nm) and UVA (320-400 nm) wavelengths. Since UVA is less energetic than UVB, UVB has long been thought to be the factor responsible for the damaging effects of solar radiation. But with modern tools such as in vitro models, it has been proven that UVA plays a major role. The objective of this review is to show how skin may be exposed to UV light and to highlight the clinical aspects of UV-induced skin damages with the respective contribution of UVB or UVA. Even if UVA is less energetic than UVB, it is more abundant and penetrates deeper into the skin, reaching as far as the dermis. Various factors also influence skin exposure to UV light: the latitude, season, and time of the day. Acute as well as chronic sun exposure induces short- and long-term clinical damages. Erythema and pigmentation are immediate responses of normal human skin exposed to UV radiation. The long-term effects are photoaging and photocarcinogenesis. In particular, UVA appears to play a major role in the deterioration of dermal structure leading to the photoaged appearance of the skin.

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Section: Pigmentationmentioning

confidence: 99%

Cutaneous solar ultraviolet exposure and clinical aspects of photodamage

Battie¹,

Verschoore²

2012

Indian J Dermatol Venereol Leprol

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“…1 In Asians, the BCC, which typically presents as pigmented skin lesions with a rolled pearly border and telangiectasia, 1,2 is the most common skin cancer, accounting for ∼70% of all malignant cutaneous tumors. 1,2 Although it rarely metastasizes, BCC can cause significant destruction and disfigurement by local invasion. 3 Melanocytic nevus and seborrheic keratosis (SK) are the two most common benign pigmented skin lesions that, importantly, may mimic BCC clinically.…”

Section: Introductionmentioning

confidence: 99%

Differential diagnosis of nonmelanoma pigmented skin lesions based on harmonic generation microscopy

et al. 2014

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Abstract. In vivo harmonic generation microscopy (HGM) has been applied successfully in healthy human skin and can achieve a submicron resolution, similar to histopathologic examination, even at a penetration depth up to 270 μm. This study aims to investigate the clinical applicability of HGM imaging for differential diagnosis of nonmelanoma pigmented skin lesions. A total of 42 pigmented skin tumors, including pigmented basal cell carcinoma, melanocytic nevus, and seborrheic keratosis were evaluated by HGM ex vivo or in vivo. Based on the standard histopathologic characteristics, we established the corresponding HGM imaging criteria for each pigmented tumor. Diagnostic performance of HGM for differentiating nonmelanoma pigmented skin tumors was evaluated through the observers' direct general assessment (overall evaluation) or the presence of two imaging criteria with the highest sensitivity and specificity (major criteria evaluation). Our results show that, based on the direct general assessment, the sensitivity is 92% [95% confidence interval (CI): 67 to 97%] and the specificity is 96% (95% CI: 83 to 99%); by major criteria evaluation, 94% sensitivity (95% CI: 70 to 99%) and 100% specificity (95% CI: 87 to 100%) are achieved. Our study indicates that HGM serves as a promising histopathological examination tool for noninvasive differential diagnostics of nonmelanoma pigmented skin tumors. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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“…[1] Though NMSC is uncommon in Asians, SCC is the most prevalent skin malignancy reported in India. [2] The exact incidence in India is however unreported in literature. NMSC occupies a small space in the perception of clinical dermatologists in India mainly because of the supposedly protective effects of eumelanin in the brown skin of the Indian population.…”

Section: Introductionmentioning

confidence: 99%

“…However, studies show that a large variety of cases, including atypical forms of NMSC do occur in Indians. [2]…”

Section: Introductionmentioning

confidence: 99%

Ingenol mebutate: A novel topical drug for actinic keratosis

Aditya

Gupta

2013

Indian Dermatol Online J

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The global incidence of non-melanoma skin cancer is rising. Significant morbidity leading to unacceptable cosmetic outcomes and/or functional impairment is a major concern. Search for non-surgical, non-invasive and tissue-sparing treatment modalities has led to development of new therapeutic agents. Actinic keratoses (AK) are one part of a continuous spectrum of benign sun damage to squamous cell carcinoma (SCC). Although it is not possible to predict which AK might progress to SCC, the presence of AK is a biomarker of risk for patients and must be treated to avoid possible morbidity and mortality. Ingenol mebutate is a novel topical drug from the latex sap of a plant-Euphorbia peplus that acts by chemoablative and immunostimulatory properties. Clinical studies have proven it to be safe and efficacious, leading to FDA approval of this chemotherapeutic agent for field therapy of AK in 2012. Current topical agents for field therapy of AK must be applied for weeks, whereas ingenol needs to be applied for three days. Ingenol offers a new therapeutic option that is convenient, safe, effective, acceptable and well-tolerated.

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Nonmelanoma skin cancer in India: Current scenario

Cited by 53 publications

References 56 publications

Cutaneous solar ultraviolet exposure and clinical aspects of photodamage

Cutaneous solar ultraviolet exposure and clinical aspects of photodamage

Differential diagnosis of nonmelanoma pigmented skin lesions based on harmonic generation microscopy

Ingenol mebutate: A novel topical drug for actinic keratosis

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