Squamous Cell Carcinoma of the Oral Tongue in Young Patients: Outcomes and Implications for Treatment

Subramaniam, Narayana; Balasubramanian, Deepak; Low, Tsu-Hui Hubert; Vidhyadharan, Sivakumar; Menon, Anjali Kondur; Murthy, Samskruthi; Thankappan, Krishnakumar; Clark, Jonathan; Gao, Kan; Iyer, Subramania

doi:10.1007/s13193-020-01049-y

Cited by 17 publications

(20 citation statements)

References 23 publications

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“…Table 1 presents the characteristics of the studies ( 20 , 25 – 32 , 43 – 50 ), including one RCT ( 43 ), three prospective cohort studies ( 44 – 46 ), and 13 retrospective studies ( 20 , 25 – 32 , 47 – 50 ). Eight studies were from Asia ( 20 , 30 , 32 , 43 , 44 , 46 , 47 , 50 ), one was Australia ( 45 ), three were from Europe ( 25 , 28 , 29 ), and five were from North America ( 26 , 27 , 31 , 48 , 49 ). The 17 studies included a total of 4445 patients.…”

Section: Resultsmentioning

confidence: 99%

“…Supplementary Table S1 shows that the RCT ( 43 ) had a low risk of bias. Among the cohort studies, three ( 26 , 30 , 49 ) scored 7 stars, four ( 27 , 29 , 47 , 48 ) scored 8 stars, and two ( 44 , 45 ) scored 9 stars ( Supplementary Table S1 ). For the other studies evaluated using MINORS, one ( 32 ) scored 5 points, five ( 20 , 25 , 28 , 31 , 50 ) scored 6 points, and one ( 46 ) scored 8 points ( Supplementary Table S3 ).…”

Section: Resultsmentioning

confidence: 99%

“…The presence of PNI was reported with a worse CSS in the adjusted analysis (20,26,29,43,45) 5 and Table 2).…”

Section: Impact Of Pni On Locoregional Recurrence and Survivalmentioning

confidence: 90%

“…Table 1 presents the characteristics of the studies (20,(25)(26)(27)(28)(29)(30)(31)(32)(43)(44)(45)(46)(47)(48)(49)(50), including one RCT (43), three prospective cohort studies (44)(45)(46), and 13 retrospective studies (20,(25)(26)(27)(28)(29)(30)(31)(32)(47)(48)(49)(50). Eight studies were from Asia (20,30,32,43,44,46,47,50), one was Australia (45), three were from Europe (25,28,29), and five were from North America (26,27,31,48,49).…”

Section: Selection Of the Studiesmentioning

confidence: 99%

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Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Liu

et al. 2021

Front. Oncol.

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ObjectivesA significant number of recently published research has outlined the contribution of perineural invasion (PNI) to clinical outcomes in oral tongue squamous cell carcinoma (OTSCC), but some results remain conflicting. This study aimed to determine whether patients with OTSCC with PNI have a worse prognosis than those without PNI.Materials and MethodsPubMed, Embase, and the Cochrane Library were queried for potentially eligible articles published up to December 2020. The primary outcomes were the hazard ratio (HR) for locoregional recurrence, overall survival (OS), disease-free survival (DFS), and cancer-specific survival (CSS). The random-effect model was used in all analyses.ResultsSeventeen studies (4445 patients) were included. Using adjusted HRs, the presence of PNI was associated with a higher risk of locoregional recurrence (HR=1.73, 95%CI: 1.07-2.79, P=0.025, I2 = 33.1%, Pheterogeneity=0.224), worse OS (HR=1.94, 95%CI: 1.39-2.72, P<0.001, I2 = 0.0%, Pheterogeneity=0.838), worse DFS (HR=2.13, 95%CI: 1.53-2.96, P<0.001, I2 = 48.4%, Pheterogeneity=0.071), and worse CSS (HR=1.93, 95%CI: 1.40-2.65, P<0.001, I2 = 25.5%, Pheterogeneity=0.251). PNI had an impact on locoregional recurrence in early-stage OTSCC but not in all stages, and on OS, DFS, and CSS in all-stage and early-stage OTSCC. The sensitivity analyses showed that the results were robust.ConclusionThe presence of PNI significantly affects the locoregional recurrence and survival outcomes among patients with OTSCC.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…The presence of PNI was reported with a worse CSS in the adjusted analysis (20,26,29,43,45) 5 and Table 2).…”

Section: Impact Of Pni On Locoregional Recurrence and Survivalmentioning

confidence: 90%

Section: Selection Of the Studiesmentioning

confidence: 99%

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Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Liu

et al. 2021

Front. Oncol.

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“…There were 26 studies originated from Asian countries (China, India, Korea, Japan, and Pakistan), and the remaining ten studies were from non-Asian countries (USA, Europe, Australia, Italy and Brazil). Among them, ten studies included oral tongue SCC [14][15][16][17][18][19][20][21][22][23][24] , and the other two studies were focused on floor of mouth cancer 7 and buccal mucosa SCC 25 , respectively. The tumor site of OSCC was mixed in the other 24 studies .…”

Section: Study Characteristics Of Included Studiesmentioning

confidence: 99%

Impact of lymphovascular invasion in oral squamous cell carcinoma: A meta-analysis

Huang

Zhu

Cai

et al. 2021

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Trends in Oral Tongue Cancer Incidence in the US

Burus,

Damgacioglu,

Huang

et al. 2024

JAMA Otolaryngol Head Neck Surg

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ImportanceOral tongue cancer (OTC) incidence has increased rapidly among young (&lt;50 years) non-Hispanic White individuals in the US during the past 2 decades; however, it is unknown if age-associated trajectories have persisted.ObjectiveTo examine US trends in OTC incidence and project future case burden.Design, Setting, and ParticipantsThis cross-sectional analysis of OTC incidence trends used the US Cancer Statistics Public Use Database, which covers approximately 98% of the US population, and included individuals with an OTC diagnosis reported to US cancer registries between January 1, 2001, and December 31, 2019.ExposuresSex, race and ethnicity, and age.Main Outcomes and MeasuresEstimated average annual percentage change in OTC incidence from 2001 to 2019. Given the substantial incidence rate increases among non-Hispanic White individuals compared with those of racial and ethnic minority groups, subsequent analyses were restricted to non-Hispanic White individuals. Forecasted OTC incidence trends and case burden among non-Hispanic White individuals to 2034.ResultsThere were 58 661 new cases of OTC identified between 2001 and 2019. Male individuals (57.6%), non-Hispanic White individuals (83.7%), those aged 60 years or older (58.0%), and individuals with localized stage disease at diagnosis (62.7%) comprised most cases. OTC incidence increased across all age, sex, and racial and ethnic groups, with marked increases observed among non-Hispanic White individuals (2.9% per year; 95% CI, 2.2%-3.7%). Increases among female individuals aged 50 to 59 years were most notable and significantly outpaced increases among younger non-Hispanic White female individuals (4.8% per year [95% CI, 4.1%-5.4%] vs 3.3% per year [95% CI, 2.7%-3.8%]). While all non-Hispanic White birth cohorts from 1925 to 1980 saw sustained increases, rates stabilized among female individuals born after 1980. Should trends continue, the burden of new OTC cases among non-Hispanic White individuals in the US is projected to shift more toward older individuals (from 33.1% to 49.3% among individuals aged 70 years or older) and female individuals (86% case increase vs 62% among male individuals).Conclusions and RelevanceThe results of this cross-sectional study suggest that the period of rapidly increasing OTC incidence among younger non-Hispanic White female individuals in the US is tempering and giving way to greater increases among older female individuals, suggesting a birth cohort effect may have been associated with previously observed trends. Recent increases among non-Hispanic White individuals 50 years or older of both sexes have matched or outpaced younger age groups. Continuing increases among older individuals, particularly female individuals, may be associated with a shift in the OTC patient profile over time.

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Squamous Cell Carcinoma of the Oral Tongue in Young Patients: Outcomes and Implications for Treatment

Cited by 17 publications

References 23 publications

Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Prognostic Value of Perineural Invasion in Oral Tongue Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

Impact of lymphovascular invasion in oral squamous cell carcinoma: A meta-analysis

Trends in Oral Tongue Cancer Incidence in the US

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