Impact of lymphovascular invasion in oral squamous cell carcinoma: A meta-analysis

Huang, Shuojin; Zhu, Yue; Cai, Hao; Zhang, Yadong; Hou, Jinsong

doi:10.1016/j.oooo.2020.10.026

Cited by 40 publications

(43 citation statements)

References 56 publications

(60 reference statements)

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“…As an essential step in tumor metastasis, LVI has been considered a prognostic marker for poor prognosis in patients with OSCC ( 57 ). In the current meta-analysis of 30 studies for OS (30,481 samples), 30 studies for DFS (8,187 samples), and 13 for DSS (4,411 samples), we confirmed the significant prognostic role of LVI for OSCC.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

et al. 2021

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ObjectiveOver many decades, studies on histopathological features have not only presented high-level evidence of contribution for treatment directions and prognosis of oral squamous cell carcinoma (OSCC) but also provided inconsistencies, making clinical application difficult. The 8th TNM staging system of OSCC has acknowledged the importance of some histopathological features, by incorporating depth of invasion (DOI) to T category and extranodal extension (ENE) to N category. The aim of this systematic review with meta-analysis is to determine the most clinically relevant histopathological features for risk assessment and treatment planning of OSCC and to elucidate gaps in the literature.MethodsA systematic review was conducted using PRISMA guidelines, and the eligibility criteria were based on population, exposure, comparison, outcome, and study type (PECOS). PubMed, Cochrane, Scopus, and Web of Science were searched for articles exploring the impact of histopathological features on OSCC outcomes with Cox multivariate analysis. Pooled data were subjected to an inverse variance method with random effects or fixed effect model, and the risk of bias was evaluated using quality in prognosis studies (QUIPS). Quality of evidence was assessed with the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) criteria.ResultsThe study included 172 articles published from 1999 to 2021. Meta-analyses confirmed the prognostic potential of DOI, ENE, perineural invasion, lymphovascular invasion, and involvement of the surgical margins and brought promising results for the association of bone invasion, tumor thickness, and pattern of invasion with increased risk for poor survival. Although with a small number of studies, the results also revealed a clinical significance of tumor budding and tumor-stroma ratio on predicted survival of patients with OSCC. Most of the studies were considered with low or moderate risk of bias, and the certainty in evidence varied from very low to high.ConclusionOur results confirm the potential prognostic usefulness of many histopathological features and highlight the promising results of others; however, further studies are advised to apply consistent designs, filling in the literature gaps to the pertinence of histopathological markers for OSCC prognosis.Systematic Review RegistrationInternational Prospective Register of Systematic Reviews (PROSPERO), identifier CRD42020219630.

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Section: Discussionmentioning

confidence: 99%

The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

et al. 2021

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“…In our study, patients were divided into nodal-negative and -positive groups, with predictive models established separately for each group. In addition to the shortened interval of locoregional control, other independent factors were related to cancer metastasis, such as age, surgical margin, and lymphovascular invasion status ( 30 – 32 ). In the nodal-negative group, although only 5.4% (25/459) of the patients developed DM during the follow-up period, most (77.1% [459/595]) of the patients with OCSCC were in this group, and this first predictive model was established for them.…”

Section: Discussionmentioning

confidence: 99%

Prediction Model of Distant Metastasis in Oral Cavity Squamous Cell Carcinoma With or Without Regional Lymphatic Metastasis

Chiu

Lan

et al. 2022

Front. Oncol.

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Patients with oral cavity squamous cell carcinoma (OCSCC) who develop distant metastasis (DM) face poor outcomes, and effective prediction models of DM are rare. A total of 595 patients with OCSCC were retrospectively enrolled in this study. Because pathological N staging significantly influences the development and mechanisms of DM, the patients were divided into nodal-negative (pN−) and -positive (pN+) groups. Clinical outcomes, prognoses, and prediction models were analyzed separately for both groups. Overall, 8.9% (53/595) of these patients developed DM. Among the DM cases, 84.9% (45/53) of them developed DM within the first 3 years. The median overall survival, locoregional recurrence-free survival, time until DM development, and postmetastatic survival were 19.8, 12.7, 14.6, and 4.1 months, respectively. Distinguishing patients who only developed locoregional recurrence from those with DM according to locoregional conditions was difficult. Age, surgical margin, and early locoregional recurrence were predictors of DM that were independent of time until DM in the pN− group; the lymphocyte-to-monocyte ratio, presence of lymphovascular invasion, and early locoregional recurrence in the pN+ group were determined. If one point was scored for each factor, then two scoring systems were used to classify the patients into low- (score = 0), intermittent- (score = 1), or high- (score = 2 or 3) risk for the pN− and pN+ groups. According to this scoring system, the 3-year DM rates for the low, intermittent, and high risk subgroups were 0.0%, 5.9%, and 17.8% for the pN− group and 7.1%, 44.9%, and 82.5% for the pN+ group, respectively. These systems also effectively predicted DM, and the areas under the curve predicted DM occurring within the first 3 years were 0.744 and 0.820 for the pN− and pN+ groups, respectively. In conclusion, effective scoring models were established for predicting DM.

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“….However younger crowd is showing more inclination towards OSCC nowadays. Therefore potential valuable markers in OSCC must be discovered for risk evaluation [1]. Researchers had studied metastatic invasive prognosticators histopathologically-Perineural invasion, Vascular invasion, Lymph node invasion, Bone invasion, Muscle invasion & Salivary gland invasion singly or in combination of 3 or 4 in H & E stained sections but no potential prognosticator was identified to be a sufficiently strong indicator of 5 years survival.…”

Section: Methodsmentioning

confidence: 99%

“…Many studies have concluded that tumor budding, depth of invasion, and lymphovascular invasion (LVI) are predictors of lymph node metastasis (LNM). In LVI cancer cells invade an endothelium-lined area of vessels [1]. LVI can be seen both 'intratumoral and extratumoral'.…”

Section: Lymphatic and Vascular Invasionmentioning

confidence: 99%

“…However younger population is more succumbed to OSCC now a days. So there is a need for exploring potential valuable markers in OSCC [1]. Researchers had studied metastatic invasive prognosticators histopathologically-Perineural invasion, Vascular invasion, Lymph node invasion, Bone invasion, Muscle invasion & Salivary gland invasion singly or in combination of 3 or 4 in H & E stained sections but no potential prognosticator identified to be a sufficiently strong indicator of 5 years survival.Variations in the criteria of invasive prognosticators in advancing OSCC and potential consequences of treatment suggest a lack of consent regarding postoperative adjuvant therapy, as well as the need for additional study.…”

Section: Introductionmentioning

confidence: 99%

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Correlation of Histopathological Metastatic Invasive Prognosticators with Five Years Survival of Oral Squamous Cell Carcinoma

Patil

2021

JPRI

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Background: OSCC is the 3rd widespread malignancy in India followed by cervical and breast cancer. Histopathological findings in the tumor are the most prominent factors identified for OSCC progression. Clinical and histopathological prognosis in OSCC like perineural invasion, vascular invasion, lymph node invasion have been studied extensively by many researchers separately or in combination since many years. Bone invasion, muscle invasion and salivary gland invasion are explored less. In order to collectively correlate the role of all prognosticators with 5 years survival, the later prognosticators are included in our study in isolation which may predict accurately the probability of 5 year survival of OSCC. Also we have to search role of the prognosticator which is most commonly affecting 5 years survival of OSCC cases so that it may modify the potential consequence of management of OSCC. Objectives: The aim of this study is to assess the relevance of histopathological invasive prognosticators on 5 years survival of oral squamous cell carcinoma (OSCC) patients visiting Sharad Pawar Dental College and Hospital, Sawangi, Wardha (MS). Methodology: Departmental reports will be screened and specimen mounted slides of histopathologically diagnosed 200 OSCC patients, who undergone surgical resection will be observed under binocular microscope. Data of dead and survived OSCC patients undergone surgery 5 years back will be collected by telecommunication. Histopathological invasive prognosticators will be analyzed and correlated with 5-years survival after treatment. Expected Results: Collectively correlating the role of histopathological invasive prognosticators in our study may predict the probability of 5 years survival of OSCC cases more accurately. Discovering diversed histopathological patterns of all metastatic prognosticators and their correlation with 5 years survival. Identification of most effective histopathological invasive prognosticator predicting 5 year survival. Conclusion: The most commonly found prognosticators in OSCC patients who died within 5 years versus others who survived for 5 years will be discovered. In addition the most common histopathological pattern related to dead and survived patients after 5 years will be found which can modify the potential consequence of management of OSCC.

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Impact of lymphovascular invasion in oral squamous cell carcinoma: A meta-analysis

Cited by 40 publications

References 56 publications

The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

The Impact of Histopathological Features on the Prognosis of Oral Squamous Cell Carcinoma: A Comprehensive Review and Meta-Analysis

Prediction Model of Distant Metastasis in Oral Cavity Squamous Cell Carcinoma With or Without Regional Lymphatic Metastasis

Correlation of Histopathological Metastatic Invasive Prognosticators with Five Years Survival of Oral Squamous Cell Carcinoma

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