Squamous Cell Carcinoma of the Ovary. A Case Report.

Shimamatsu, Kazuhide; Iemura, Akihiro; Nakashima, Osamu; Taguchi, Jun; Inoue, Midori; Higaki, Koichi; Kojiro, Masamichi; Kataoka, Akio; Nishida, Takashi; Yakushiji, M

doi:10.2739/kurumemedj.41.177

Cited by 4 publications

(2 citation statements)

References 13 publications

(17 reference statements)

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“…Stepwise serial sections disclosed that the tumor nests were contiguous to the epithelium of inclusion cyst showing squamous metaplasia. The tumor was diagnosed as SCC arising from the epithelium of surface [ 25 ]. Park el al.…”

Section: Discussionmentioning

confidence: 99%

Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

et al. 2017

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ObjectiveThe malignant transformation (MT) of ovarian mature cystic teratoma (MCT) to squamous cell carcinoma (SCC) is very rare. This study analyzed cases from multiple medical centers in Taiwan to investigate the clinicopathologic characteristics, treatment, and prognostic factors of this disease and reviewed related literature.MethodsPathological reports of 16,001 patients with primary ovarian cancer who were treated at Taiwan medical centers from 1990 to 2011 were reviewed. In total, 52 patients with MT of MCT to SCC were identified.ResultsAmong all ovarian MCTs, the incidence of MT to SCC is 0.2%. The median age of patients was 52 years (range, 29–89 years), and the mean tumor size was 10.5 cm (range, 1–40 cm). We analyzed the patients in our study and those in the literature and determined that early identification and complete surgical resection of the tumor are essential for long-term survival. In addition, adjuvant chemotherapy or concurrent chemoradiotherapy can be used to treat this malignancy. Old age, large tumor size (≥15.0 cm), and solid components in MCTs are suitable indicators predicting the risk of MT of MCT to SCC.ConclusionSimilar to general epithelial ovarian cancers, the early detection of MT of MCT to SCC is critical to long-term survival. Therefore, older patients with a large tumor or those with a tumor containing a solid component in a clinically diagnosed MCT should be evaluated to exclude potential MT to SCC.

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Section: Discussionmentioning

confidence: 99%

Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

et al. 2017

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“…Park et al [ 12 ] posited a relationship between ovarian SCC and human papilloma virus infection, because 11 of 27 patients with ovarian SCC had cervical carcinoma in situ, cervical intraepithelial neoplasia, or vulvar intraepithelial neoplasia [ 13 ]. Shimamatsu et al [ 14 ] estimated that the malignant transformation from squamous metaplasia of ovarian epithelial inclusion cysts is one of the causes of ovarian SCC.…”

Section: Discussionmentioning

confidence: 99%

Long-term recurrence-free survival of a patient with advanced pure primary ovarian squamous cell carcinoma treated with dose-dense paclitaxel combined with carboplatin

et al. 2017

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We describe an extremely rare case of advanced pure primary ovarian squamous cell carcinoma (SCC), treated by adjuvant chemotherapy with dose-dense paclitaxel combined with carboplatin (dd-TC) plus the combination chemotherapy with irinotecan and cisplatin (CPT-P), with long-term recurrence-free survival. A 71-year-old woman complaining of lower abdominal pain was referred to our hospital and a 7-cm-diameter solid tumor was identified. She was diagnosed with a left ovarian tumor that was highly suspicious for malignancy based on ultrasonography, magnetic resonance imaging, and contrast-enhanced computed tomography. Bilateral salpingo-oophorectomy, low-anterior colon resection, and colostomy were performed. Intra- and post-operative histopathological diagnosis revealed International Federation of Gynecology and Obstetrics stage IIIc well-differentiated pure ovarian SCC. As adjuvant chemotherapy, 2 courses of dd-TC were administered, followed by 3 courses of CPT-P; the patient then underwent 4 additional courses of dd-TC. Both regimens were effective and there has been no recurrence or metastasis thus far in the 5 years since the operation.

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Prognosis and Treatment of Squamous Cell Carcinoma from a Mature Cystic Teratoma of the Ovary

Chen

Chang

et al. 2008

Journal of the Formosan Medical Association

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Squamous Cell Carcinoma of the Ovary. A Case Report.

Cited by 4 publications

References 13 publications

Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

Malignant transformation of ovarian mature cystic teratoma into squamous cell carcinoma: a Taiwanese Gynecologic Oncology Group (TGOG) study

Long-term recurrence-free survival of a patient with advanced pure primary ovarian squamous cell carcinoma treated with dose-dense paclitaxel combined with carboplatin

Prognosis and Treatment of Squamous Cell Carcinoma from a Mature Cystic Teratoma of the Ovary

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