Long-term recurrence-free survival of a patient with advanced pure primary ovarian squamous cell carcinoma treated with dose-dense paclitaxel combined with carboplatin

Abstract

We describe an extremely rare case of advanced pure primary ovarian squamous cell carcinoma (SCC), treated by adjuvant chemotherapy with dose-dense paclitaxel combined with carboplatin (dd-TC) plus the combination chemotherapy with irinotecan and cisplatin (CPT-P), with long-term recurrence-free survival. A 71-year-old woman complaining of lower abdominal pain was referred to our hospital and a 7-cm-diameter solid tumor was identified. She was diagnosed with a left ovarian tumor that was highly suspicious for malignancy based on ultrasonography, magnetic resonance imaging, and contrast-enhanced computed tomography. Bilateral salpingo-oophorectomy, low-anterior colon resection, and colostomy were performed. Intra- and post-operative histopathological diagnosis revealed International Federation of Gynecology and Obstetrics stage IIIc well-differentiated pure ovarian SCC. As adjuvant chemotherapy, 2 courses of dd-TC were administered, followed by 3 courses of CPT-P; the patient then underwent 4 additional courses of dd-TC. Both regimens were effective and there has been no recurrence or metastasis thus far in the 5 years since the operation.

Oxidative stress induced by carboplatin promotes apoptosis and inhibits migration of HN‑3 cells

“…Among these types of agents, CBDCA, a second-generation platinum anti-cancer agent, was developed to overcome the side effects of cisplatin, including nephrotoxicity and neurotoxicity ( 36 ). CBDCA has notable antitumor activity against a variety of cancer types, including ovarian and small-cell lung cancer ( 31 , 32 ). Previous studies have demonstrated that the oxidative stress caused by ROS promoted the apoptosis of LSCC cells through a number of functional mechanisms ( 16 , 17 , 37 ).…”

A Case Report of Primary Ovarian Squamous Cell Carcinoma: Pathways (And Pitfalls) To A Difficult Diagnosis

“…Hence, whilst tubo-ovarian abscess is most commonly a late sequelae of PID there are other rarer causes, and indeed alternative diagnoses to be con-sidered [9]. With this in mind, the initial diagnosis of diverticulitis is not unreasonable given that this is the most common non-neoplastic GI cause of postmenopausal tubo-ovarian abscess [7,4] and the patient's history of diverticulitis. However, she did not improve with treatment suggesting that this presentation was unlikely to be complicated diverticulitis alone.…”

“…This is particularly important because given the rarity of this condition, established treatment protocols have not yet been established [1,5]. There have been only three reported cases of response to adjuvant chemotherapy; a single reported case of resulting in recurrence-free survival at five years reported by Yazawa et al A patient with FIGO stage IIIc pure primary ovarian SCC and two further cases of survival at 18 and 19 months [7].…”

Primary Squamous Cell Carcinoma of the Ovary

“…MCT is one of the most common benign ovarian tumors and has an incidence of malignant transformation of about 1%-2%. The most common transformation in an MCT is SCC, although adenocarcinoma, sarcoma, and carcinoid have also been rarely reported [4]. Ovarian SCCs arising within a dermoid cyst appear incidentally on histology.…”

“…However, many suspicious morphological changes are identified during follow-up, and as a result, over 60% of the cases are identified at stage I or II of SCC. Moreover, such transformations are also occasionally identified during the postoperative pathological examination of the resected MCT tumors that were originally considered to be benign [4].…”