Squamous cell carcinoma of the temporal bone: Outcomes of radical surgery and postoperative radiotherapy

Leong, Samuel; Youssef, Ahmed; Lesser, T. H. J.

doi:10.1002/lary.24063

Cited by 67 publications

(84 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…6 Despite advances in the management of temporal bone malignancies, staging and prognostic predictors for tumors remain elusive. The Pittsburgh Staging Criteria proposed by Arriaga et al 7 in 1990 is widely utilized, and has been shown to correlate with prognosis in several retrospective studies, [8][9][10][11] although no significant correlation was observed in others. 11 In previous studies, obtaining negative margins as well as lymph node status have been shown to be important predictors of survival.…”

Section: Introductionmentioning

confidence: 99%

Update on Surgical Outcomes of Lateral Temporal Bone Resection for Ear and Temporal Bone Malignancies

et al. 2016

View full text Add to dashboard Cite

Section: Introductionmentioning

confidence: 99%

Update on Surgical Outcomes of Lateral Temporal Bone Resection for Ear and Temporal Bone Malignancies

et al. 2016

View full text Add to dashboard Cite

“…A number of factors other than the tumors stage, poorly differentiated tumors [35], lymph node involvement, and facial nerve palsy [36] have been noted to confer poor prognosis. Possible predisposing factors for the disease are preceding head and neck radiation for nasopharyngeal and skin neoplasms [36].…”

Section: Discussionmentioning

confidence: 99%

Hearing Loss Revealing a Squamous Cell Carcinoma of External Auditory Canal in a Post-Irradiated Patient for Nasopharyngeal Carcinoma

Chafiki¹

2017

MOJBM

View full text Add to dashboard Cite

Background: Primary Carcinoma of external auditory canal (EAC) is a rare disease accounting for less than 2% of head and neck cancers and has an annual incidence of around 1 per million populations. EAC carcinoma in postirradiated nasopharyngeal carcinoma (NPC) patients occurs with an incidence of approximately 0.15%. It arises from the external ear and spreads to the temporal bone and surrounding sites. Although its rarity, it is a life threatening disease with practically a poor constant prognosis. Primary EAC carcinoma can occur with no specific symptoms. Aggressive surgery with postoperative radiation remains the usual treatment until now. We report a rare case of a squamous cell carcinoma (SCC) of EAC revealed by a progressive hearing loss as first presentation of the disease in a post-irradiated woman for NPC. Results:A 47-year-old female with a past medical history of nasopharyngeal carcinoma treated with chemo radiation therapy, presented for repeated leftsided purulent ear discharge and progressive hearing loss. Otoscopic examination revealed a tissue mass filling the left EAC. CT scan revealed a soft tissue density process filling the EAC, encroaching upon the tympanic cavity and coming into contact with the handle of the malleus neither with no acicular lyses nor EAC walls erosion. The biopsy of the mass was consistent with EAC SCC. The patient under went lateral temporal bone resection with homolateral superficial parotidectomy and selective neck dissection and completed by an adjuvant external radiation therapy [RT]. Conclusion:Post-irradiation EAC SCC has similar symptoms and invades similar regions as its primary counterpart. This entity is usually discovered in the early stage in post-irradiated EAC SCC patients comparing to the primary EAC SCC. Aggressive surgical treatment is strongly recommended, but adjuvant radiotherapy for early stage EAC SCC should be provided cautiously to prevent further radiation induced complications.

show abstract

“…23 Facial nerve sacrifice was also related to poor prognosis, 10 both in the condition of clinical preoperative involvement and in the necessity to sacrifice it for oncological reasons in the surgical approach. Dural infiltration was the strongest reported negative factor affecting survival.…”

Section: Discussionmentioning

confidence: 99%

“…10,18 In part, facial nerve involvement continues to be controversial with a significant negative prognostic role found by most 11,12,15,16,[19][20][21][22] but not all groups. 23 Dura mater infiltration evidence (both radiological and/or pathological) was reported in most of the series 10,11,21,22 as the strongest negative prognostic factor affecting survival.…”

Section: Conventional Clinico-pathological Variables and Prognosismentioning

confidence: 96%

See 1 more Smart Citation

Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence

Zanoletti

Marioni

Franchella

et al. 2016

Reports of Practical Oncology & Radiotherapy

View full text Add to dashboard Cite

show abstract

Squamous cell carcinoma of the temporal bone: Outcomes of radical surgery and postoperative radiotherapy

Abstract: 4.

Cited by 67 publications

References 16 publications

Update on Surgical Outcomes of Lateral Temporal Bone Resection for Ear and Temporal Bone Malignancies

Update on Surgical Outcomes of Lateral Temporal Bone Resection for Ear and Temporal Bone Malignancies

Hearing Loss Revealing a Squamous Cell Carcinoma of External Auditory Canal in a Post-Irradiated Patient for Nasopharyngeal Carcinoma

Temporal bone carcinoma: Classical prognostic variables revisited and modern clinico-pathological evidence

Contact Info

Product

Resources

About