Squamous cell carcinoma of the oral cavity in young adults

Amsterdam, James T.; Strawitz, Joseph G.

doi:10.1002/jso.2930190202

Cited by 71 publications

(58 citation statements)

References 5 publications

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“…This is similar to the rate of tobacco use in young patients with head and neck cancer reported in other series. [1][2][3]8,[10][11][12] The older group had a slightly higher smoking prevalence: 58%.…”

Section: Discussionmentioning

confidence: 99%

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Squamous cell carcinoma of the tongue in young patients: A matched-pair analysis

et al. 1998

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Section: Discussionmentioning

confidence: 99%

“…Many authors conclude that these patients have a worse outcome than their older counterparts. [1][2][3][4] Son and Kapp 1 reviewed the Yale-New Haven Medical Center experience from 1958 through 1980. They identified 27 patients below the age of 40 years with SCC of the oral cavity and oropharynx.…”

mentioning

confidence: 99%

Squamous cell carcinoma of the tongue in young patients: A matched-pair analysis

et al. 1998

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“…Studies on whether the age at diagnosis affects the prognosis revealed conflicting data. 5 Son and Kapp, 2 Amsterdam and Strawitz, 6 and Sarkaria and Harari 7 concluded that young patients have worse outcomes than their older counterparts. 5 There is a generally held view that oral cancers in young people are more aggressive and have a worse prognosis.…”

Section: Introductionmentioning

confidence: 98%

Analysis of clinical and histopathological profiles of oral squamous cell carcinoma in young Indian adults: A retrospective study

Acharya

Tayaar

2012

Journal of Dental Sciences

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Background/purpose: Substantial debate exists in the literature regarding the clinical course of young patients with oral squamous cell carcinoma (OSCC). Based on young subjects with OSCC reported at our institution, the clinicopathological features of OSCC in young patients were studied in order to determine if there were any defining characteristics in this population. Materials and methods: All cases of OSCC reported in our institution in 2005e2009 were scrutinized. Clinicopathological features of patients aged 40 years (young patients) at the time of the initial diagnosis were compared to patients aged >40 years (older patients), and there was twice the number of older than younger patients. Results: In a span of 5 years, there were 82 (24.6%) young patients ( 40years) out of 333 OSCC patients reported, and the majority were males. The bulk of OSCC patients had chewing habits of tobacco and areca nut products, and the percentage of patients using commercially available pan-tobacco products among young patients were higher compared to older patients. Exophytic growth was a common morphological presentation in OSCC patients, but young patients showed a significantly higher endophytic presentation compared to older patients. There was no significant difference between study participants when histopathological grading systems of Broder and Anneroth et al were applied. Conclusion: Exposure through behavioral risk factors was similar in young and older patients; although these had less time to act in young patients, the lesions were similar in terms of size and pathology. Demographic and clinical parameters like gender, risky habits, duration of risky Journal of Dental Sciences (2012) 7, 224e230 habits, and tumor morphology were significant predictors in the study groups. Future studies should determine the prognostic values of these parameters.

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“…While the definition of what age constitutes a young head and neck patient is arbitrary, most series have assigned this definition to patients aged less than 40 years [1][2][3] although authors have used 30, 4 35, 5 and 45 6 years as an upper limit for this group.…”

Section: Introductionmentioning

confidence: 99%

Tongue cancer: Do patients younger than 40 do worse?

Hyam

Conway

Sathiyaseelan³

et al. 2003

Australian Dental Journal

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Background: Debate continues as to whether being young confers a worse prognosis for patients with squamous cell carcinoma of the tongue. Recent papers have provided conflicting views in this debate. In this study we aimed to investigate if young age at the time of diagnosis of squamous cell carcinoma of the tongue confers a worse prognosis. Methods: Eligible patients were identified through the computer database of the Department of Radiation Oncology, Westmead Hospital, Sydney. All eligible patients were treated with radical intent. Using age 40 as a cut off multivariate and survival analysis was undertaken to compare age groups. Results: Median age at diagnosis was 60 years (range, 19-86 years) in 84 males (65 per cent) and 45 females (35 per cent). Median follow-up time was 43 months (range, 2.3-203 months). Fifteen patients (12 per cent) were aged <40 years. On univariate analysis stage and age were significant determinants of disease-specific survival. There was no difference in overall survival between the young (<40 years) and middle-aged groups (40-60 years). However, the young and the middle aged were both more likely to survive than the older age group (>60 years). On multivariate analysis age remained a significant factor for determining disease-specific survival, with the older age group 2.9 times more likely to die than the younger groups. Conclusion: Young age (<40 years) did not portend to worse survival in comparison to older tongue cancer patients.

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Squamous cell carcinoma of the oral cavity in young adults

Cited by 71 publications

References 5 publications

Squamous cell carcinoma of the tongue in young patients: A matched-pair analysis

Squamous cell carcinoma of the tongue in young patients: A matched-pair analysis

Analysis of clinical and histopathological profiles of oral squamous cell carcinoma in young Indian adults: A retrospective study

Tongue cancer: Do patients younger than 40 do worse?

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