Squamous Cell Carcinoma of the Buccal Mucosa

Strome, Scott E.; To, Wyatt C.; Strawderman, Myla; Gersten, Kevin; Devaney, Kenneth O.; Bradford, Carol R.; Esclamado, Ramon M.

doi:10.1016/s0194-5998(99)70278-0

Cited by 84 publications

(65 citation statements)

References 7 publications

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“…Studies from North America and Europe have shown a consistently poor prognosis. Strome et al 21 have reported tumor recurrence in nearly 80% of 31 patients within 5 years. Pop et al 22 showed a local recurrence rate of 45% for 40 patients with buccal cancer and 70% for 10 patients with stage IV disease.…”

Section: Discussionmentioning

confidence: 98%

“…This falls within the 29% to 100% incidence reported in the literature. 15,21,23 A previous report from Taiwan on 57 patients concluded that postoperative radiotherapy was effective in decreasing locoregional failure in patients with close surgical margins, tumor thickness greater than 10 mm, high-grade tumors, and positive node and bone invasion. 13 Of the patients in this study, the S group and S + RT group had similar treatment outcomes in both early and advanced stages despite the fact that 20 of the 58 patients who had S + RT had positive or close surgical margins, whereas no patient in the S group had positive margins.…”

Section: Discussionmentioning

confidence: 99%

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Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment

et al. 2006

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Background. In our clinical practice, we have observed a high incidence of locoregional failure in squamous cell carcinoma (SCC) of the buccal mucosa. We analyze our treatment results of this cancer and compare these results with those in the literature. We intend to define the pattern and incidence of failure of buccal cancer and provide information for the design of a better multimodality treatment.Methods. During the period from 1983 through 2003, 121 previously untreated patients with M0 stage SCC of the buccal mucosa were treated with a curative intent at our hospital. Twenty-seven patients received surgery alone, 36 had radiotherapy alone, and 58 underwent surgery plus postoperative radiotherapy.Results. The 5-year locoregional control, overall survival, and cause-specific survival rates for all patients were 36.3%, 34.3%, and 36.9%, respectively. The locoregional recurrence rate was 57% for all patients, with 80% occurring in the primary site alone. Patients with T1 -2N0 disease who received surgery alone still had a high local recurrence incidence of 41%. For patients with locally advanced disease, surgery plus postoperative radiotherapy achieved better overall survival and locoregional control rates than surgery alone or radiotherapy alone. T classification was the only prognostic factor affecting locoregional control and survival in the surgery alone group, whereas N classification and skin invasion predicted a poorer survival for the surgery plus postoperative radiotherapy group.Conclusions. SCC of the buccal mucosa is an aggressive cancer with a high locoregional failure rate even in patients with T1 -2N0 disease. Possible reasons include inadequate treatment and an intrinsically aggressive nature. Postoperative radiotherapy has resulted in a better locoregional control rate for patients with T3 -4 or N+ disease and should also be considered for patients with T1 -2N0 disease for whom adjuvant therapy after radical surgery currently is not recommended by most guidelines. A 2005 Wiley Periodicals, Inc. Head Neck 28: 150 -157, 2006

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment

et al. 2006

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“…6,14,19,20 Strome et al 6 reported nearly 80 per cent of patients having recurred by five years with most (72 per cent) recurrences in the buccal mucosa. In this study most patients underwent Sx alone (61 per cent), with only 29 per cent receiving Sx and adjuvant RT.…”

Section: 12mentioning

confidence: 99%

“…As a result there is a high propensity for lymphatic spread through the rich lymphatic drainage to the jugulodigastric, submental and submandibular lymph nodes. 6 The subsequent development of nodal metastases is a powerful predicator of poor outcome.…”

Section: Introductionmentioning

confidence: 99%

Role of combined modality treatment of buccal mucosa squamous cell carcinoma

Veness

Pearl-Larson

et al. 2005

Aust Dental J

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Background: Squamous cell carcinoma of the buccal mucosa is an oral cancer reported as having a poor prognosis. In many patients combined modality treatment incorporating surgery and adjuvant radiotherapy should be considered best practice. Methods: Patients treated for buccal mucosa squamous cell carcinoma were identified through the computer database in the Department of Radiation Oncology, Westmead Hospital, Sydney. All eligible patients were treated with curative intent. Survival was calculated using the KaplanMeier product limit method.

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“…Buccal SCCA was prevalent in Southeast Asia and India because of tobacco use and the chewing of betel nuts. As buccal carcinoma frequently demonstrated aggressive behaviour, and the buccal mucosa had few anatomical barriers, buccal SCCA could easily extend to neighbouring intraoral subsites and adjacent structures, [2][3][4] which affected its T-staging, surgical resectability and radiation planning.…”

Section: Introductionmentioning

confidence: 99%

Pathways involved in the spread of buccal carcinoma on contrast-enhanced multislice CT

D²,

Zhou³

et al. 2015

Dentomaxillofacial Radiology

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Objectives: To explore how buccal carcinoma spread, using contrast-enhanced multislice CT (CEMSCT). Methods: We retrospectively analysed the extent of lesions in 56 patients with primary buccal squamous cell carcinoma (SCCA). Abnormal manifestations on CEMSCT at oral subsites and involved adjacent structures were documented and evaluated, which were compared with the results of surgery and histopathology. Results: Infiltration and spread to oral subsites and/or adjacent structures was confirmed in 33 patients (58.9%). The opening of the Stensen duct was the most commonly invaded oral subsite (72.7%); other sites included the gingivobuccal sulcus (60.6%), pterygomandibular raphe (54.5%), gingiva (24.2%), retromolar trigone (24.2%), orbicularis oris (18.2%) and the floor of mouth (15.2%). Of the involved adjacent structures, the buccal space was the most common site of spread (69.7%), followed by the masticatory muscles and spaces (57.6%), bone (54.5%), skin and subcutaneous fat (39.4%), pharynx (30.3%), investing fascia (15.2%) and the base of the skull (6.1%). CEMSCT manifestations of the involvement in buccal SCCAs had correlations with pathological findings (p , 0.05). The sensitivities, specificities and accuracies of two radiologists' evaluation on buccal carcinoma involvement were 50.00%, 23.21% and 73.21%; and 51.79%, 32.14% and 83.93%, respectively.

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Squamous Cell Carcinoma of the Buccal Mucosa

Cited by 84 publications

References 7 publications

Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment

Squamous cell carcinoma of the buccal mucosa: An aggressive cancer requiring multimodality treatment

Role of combined modality treatment of buccal mucosa squamous cell carcinoma

Pathways involved in the spread of buccal carcinoma on contrast-enhanced multislice CT

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