Role of combined modality treatment of buccal mucosa squamous cell carcinoma

Abstract

Background: Squamous cell carcinoma of the buccal mucosa is an oral cancer reported as having a poor prognosis. In many patients combined modality treatment incorporating surgery and adjuvant radiotherapy should be considered best practice. Methods: Patients treated for buccal mucosa squamous cell carcinoma were identified through the computer database in the Department of Radiation Oncology, Westmead Hospital, Sydney. All eligible patients were treated with curative intent. Survival was calculated using the KaplanMeier product limit method.

Characterization of Cancer Stem Cells in Moderately Differentiated Buccal Mucosal Squamous Cell Carcinoma

“…Oral cavity squamous cell carcinoma affects the oral tongue, floor of the mouth, buccal mucosa, hard palate, mandibular and maxillary alveolus, vestibule of mouth, and retromolar trigone ( 4 , 5 ). While buccal mucosal squamous cell carcinoma (BMSCC) accounts for <10% of all OCSCC in the Western world ( 4 , 6 ), it is the most prevalent OCSCC in South East Asia and South Asia ( 6 , 7 ). This high prevalence is primarily due to the practice of betel nut chewing ( 6 , 7 ), and/or alcohol consumption ( 8 ) and/or tobacco use ( 5 ), although recent studies suggest other non-lifestyle contributing factors ( 5 ).…”

“…While buccal mucosal squamous cell carcinoma (BMSCC) accounts for <10% of all OCSCC in the Western world ( 4 , 6 ), it is the most prevalent OCSCC in South East Asia and South Asia ( 6 , 7 ). This high prevalence is primarily due to the practice of betel nut chewing ( 6 , 7 ), and/or alcohol consumption ( 8 ) and/or tobacco use ( 5 ), although recent studies suggest other non-lifestyle contributing factors ( 5 ). Due to the particularly aggressive nature of this cancer ( 9 ), patients with BMSCC have a high locoregional recurrence rate of up to 57% with associated poor survival ( 10 ).…”

Survival Following Non Surgical Treatments for Oral Cancer: a Single Institutional Result

“…Metastasis to neck node is the most important prognostic factor for oral cancer. Tumor size and T stage is another factor (Woolgar et al, 1995;Lee, 2005;Murthy et al, ????). In this study the T (p=0.02) and N (p=0.00) stage emerged as independent predictors of survival, which was in agreement with most published results (Montoro et al, 2008;Murthy et al, ????…”

BH3 mimetic Obatoclax (GX15-070) mediates mitochondrial stress predominantly via MCL-1 inhibition and induces autophagy-dependent necroptosis in human oral cancer cells

“…About 40% OSCC patients die from loco-regional disease while 24% develop distant metastases [ 4 ]. However, despite major improvements in cancer therapeutics, the 5-year survival rate of OSCC patients has not shown a significant improvement over the past several years [ 5 ]. Hence, there is an urgent need to identify more effective therapeutic agents for the better management of OSCC.…”