Squamous cell carcinoma of submandibular salivary gland: A rare case report

Manvikar, Vardendra; Ramulu, Surekha; Ravishanker, Shilpa T; Chakravarthy, Chitra

doi:10.4103/0973-029x.140909

Cited by 12 publications

(15 citation statements)

References 3 publications

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“…While all metastatic SCCs involved the parotid gland, primary SCCs affected both parotid and submandibular glands. The parotid gland is the most commonly involved major gland in primary SCC [1,3,14], although many isolated cases of submandibular gland origin have been reported [4,5,16,22,23]. The location of primary SCC as well as the age and sex of the patients were similar to those reported for salivary duct carcinomas.…”

Section: Discussionsupporting

confidence: 61%

“…Primary squamous cell carcinoma (SCC) of the salivary gland is a rare disease, accounting for 1.6% (0.3%-6.9%) of salivary gland neoplasms [1][2][3][4][5]. The salivary gland is histologically composed of secretory, ductal, and myoepithelial cells.…”

mentioning

confidence: 99%

“…Considering previous results, this study intended to determine the expressional characteristics in primary SCC and metastatic SCC [10][11][12]. Although the pathogenesis of primary SCC of the salivary gland is unknown, it can be associated with squamous metaplasia of the salivary duct or previous radiation treatment [4,5]. The aim of this study was to improve our understanding of the pathology and pathogenesis of primary Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma Background: Primary squamous cell carcinoma (SCC) of the salivary gland is a rare disease, and distinguishing primary SCC from metastatic SCC is difficult.…”

mentioning

confidence: 99%

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Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Song

Choi

et al. 2020

J Pathol Transl Med

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Background Primary squamous cell carcinoma (SCC) of the salivary gland is a rare disease, and distinguishing primary SCC from metastatic SCC is difficult. This study investigated the histological and immunohistochemical differences between primary and metastatic salivary gland SCC to improve the accuracy of diagnosis and to explore the pathogenesis of this disease. Methods Data of 16 patients who underwent surgery for SCC of salivary glands between 2000 and 2018 at Asan Medical Center were retrieved. Eight patients had a history of SCC at other sites, and eight patients had only salivary gland SCC. Immunostaining for p16, p53, androgen receptor (AR), gross cystic disease fluid protein 15 (GCDFP-15), and c-erbB2, as well as mucicarmine staining, were compared between the two groups. Results Most tumors were located in the center of the salivary glands with extraparenchymal extension. The histology of primary SCC of the salivary gland was consistent with moderately differentiated SCC with extensive desmoplastic reaction and peritumoral inflammation. Involvement of the salivary gland ducts and transition into the ductal epithelium were observed in two cases. Metastatic SCC resembled the primary tumor histologically and was associated with central necrosis. Both groups exhibited negative mucin staining. Two, one, and one primary SCC case exhibited AR, GCDFP-15, and c-erbB2 positivity, respectively. Conclusions A subset of primary SCCs originated in salivary ducts or was related to salivary duct carcinoma. Distinguishing primary from metastatic SCC of the salivary gland is difficult using histologic features and immunoprofiles. A comprehensive review of the medical history is essential.

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Section: Discussionsupporting

confidence: 61%

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confidence: 99%

mentioning

confidence: 99%

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Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Song

Choi

et al. 2020

J Pathol Transl Med

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“…The patient underwent wide excision and neck dissection for metastatic lymph nodes in neck. Manvikar et al, also reported a case similar to the present one where a 70-year-old female presented with rapidly growing submandibular swelling and was diagnosed as squamous cell carcinoma [7]. According to Rao et al, in a case report of submandibular squamous cell malignancy, the patient expired within 4 months of diagnosis due to pulmonary metastasis, highlighting the aggressive behaviour of these tumours [8].…”

Section: Discussionmentioning

confidence: 77%

Primary Squamous Cell Carcinoma of Submandibular Salivary Gland with Sialo-Cutaneous Fistula: A Rare Case Report

Kulkarni

Thakur

2015

JCDR

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“…They are unusual in patients younger than 20 years, although several cases have been described. Males are more frequently affected than females [3,8]. The major risk factors include smoking, alcohol consumption and Betel quid chewing [1].…”

Section: Discussionmentioning

confidence: 99%

Early Diagnosis of Oral Cavity Carcinomas : The Best Prognostic Factor

Nehmé

Farah²,

Hoyek-Gebeily³

et al. 2017

IAJD

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Oral mucosa neoplasms are most often pre-malignant lesions that evolved in squamous cell carcinoma (90% of cancers of the oral cavity). Tobacco and alcohol are the two most incriminated etiological factors. Other etiologies have also been mentioned, in particular the oncogenicity of certain viruses like the human papillomavirus (HPV). However, other types of cancer may occur mainly in young adults whose starting point is generally a salivary gland (10% of cancers of the oral cavity). From two clinical cases, squamous cell carcinoma and mucoepidermoid carcinoma, we describe the etiopathogenesis and the clinical characteristics as well as the histopathological particularities, diagnosis and prognosis of each of these entities. We also developped the interest of an early detection of the lesions that will provide the patient a better prognosis even though the therapeutic strategy is established in the best conditions.

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Squamous cell carcinoma of submandibular salivary gland: A rare case report

Cited by 12 publications

References 3 publications

Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Primary squamous cell carcinoma of the salivary gland: immunohistochemical analysis and comparison with metastatic squamous cell carcinoma

Primary Squamous Cell Carcinoma of Submandibular Salivary Gland with Sialo-Cutaneous Fistula: A Rare Case Report

Early Diagnosis of Oral Cavity Carcinomas : The Best Prognostic Factor

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