Squamous cell carcinoma in situ arising in mature cystic teratoma of the ovary: a case report

Zakkouri, F. A.; Ouaouch, Saloua; Boutayeb, Saber; Rimani, M.; Gamra, L.; Mrabti, Hind; Errihani, Hassan

doi:10.1186/1757-2215-4-5

Cited by 10 publications

(8 citation statements)

References 6 publications

(10 reference statements)

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“…If preoperative imaging reveals unnatural nodular areas within the cyst wall, histological analysis of frozen sections during the initial operation may avoid the need for a secondary operation for complete removal of the malignancy. Although prognosis depends on the FIGO stage [ 4 , 7 , 12 , 13 ] and malignancy may not be identified in all cases [ 22 ], avoiding a secondary operation has been demonstrated to increase the patient’s quality of life.…”

Section: Discussionmentioning

confidence: 99%

“…However, there have been previously reported cases of other types of malignancies arising from MCT, such as neuroendocrine carcinoma [ 7 – 11 ], which are unable to be identified by preoperative evaluation of SCC antigen. The prognoses of patients with such secondary malignancies depend on their International Federation of Gynecology and Obstetrics (FIGO) stage [ 4 , 7 , 12 , 13 ]. To improve patient quality of life, we investigated the usefulness of frozen section assessment during operation for confirmation of MCT malignant transformation.…”

Section: Introductionmentioning

confidence: 99%

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Relevance of frozen sections and serum markers in invasive squamous cell carcinoma arising from ovarian mature cystic teratoma: two case reports

et al. 2016

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BackgroundOvarian mature cystic teratoma (MCT) is a common neoplasm in women. While malignant transformation of MCT is relatively rare, squamous cell carcinoma is the most frequent malignant neoplasm arising from MCT. Some tumor markers have been reported to be useful for prediction of MCT malignant transformation prior to operation. However, widely accepted use of these markers remains to be established. In the present study, we report the usefulness of frozen section assessment during operation, as well as preoperative measurement of tumor marker levels.Case presentationWe present two cases of squamous cell carcinoma arising from ovarian MCT. The first case was a 45-year-old Asian woman referred to our hospital after her periodical company medical checkup, due to possible ovarian tumor. Image analysis suggested a dermoid cyst, and left salpingo-oophorectomy was performed. Because the cyst was histologically diagnosed as an invasive squamous cell carcinoma arising from an MCT, our patient underwent an additional preventative operation. The TNM classification and FIGO stage were T1aNXM0 and Ia, respectively. The second case was a 53 -year-old Asian woman who visited our hospital due to complaints of abdominal pain and urinary retention. Image analysis and laboratory data showing high serum levels of SCC antigen (normal range: < 1.5 ng/mL) and CA19-9 (normal range: < 37 U/mL), which strongly suggested malignant transformation of MCT. Frozen sections obtained during the operation were histologically analyzed to confirm malignancy, and our patient underwent an additional operation. The TNM classification and FIGO stage were T1aNXM0 and Ia, respectively.ConclusionsWe report the usefulness of frozen section assessment during operation, as well as preoperative measurement of tumor marker levels.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Relevance of frozen sections and serum markers in invasive squamous cell carcinoma arising from ovarian mature cystic teratoma: two case reports

et al. 2016

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“…However, early stage of the disease and performing an optimal cytoreductive surgery are good prognostic factors [15]. …”

Section: Discussionmentioning

confidence: 99%

Appendix and Uterus Metastasis of Squamous Cell Carcinoma Arising from Mature Cystic Teratoma of the Ovary

Balık

Üstüner

Bedir

et al. 2013

Case Reports in Obstetrics and Gynecology

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Mature cystic teratoma of the ovary rarely undergoes malignant transformation. There is no consensus for a treatment modality because of the rarity of the disease. Herein we present a case of squamous cell carcinoma (SCC) arising in a mature cystic teratoma (MCT) in a 66-year-old patient. The patient underwent total hysterectomy and bilateral salpingo-oophorectomy, omentectomy, appendectomy, and bilateral pelvic + paraaortic lymph node dissection. The histopathological examination revealed malignant invasion of the appendix and uterus. The patient, who refused the continuation of treatment initiated with the administration of a single dose of cisplatin, died 5 months later because of the disease. It is imperative that gynecologists consider appendectomy in SCC arising from MCT cases.

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“…Tumors measuring 9.9 cm or more in diameter increase the risk of malignant transformation by 86% [7]. In addition to the patient's age, tumor size and clinical stage of the tumor, there are other factors with significant effect on prediction of survival of patients with squamous cell carcinoma in mature cystic teratomas such as histological differentiation, capsular and vascular invasion and possibility of complete surgical debulking [11,12]. In our case, the tumor diameter was 20 cm, which corresponds to literature.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell carcinoma in mature cystic teratoma of the ovary

et al. 2012

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Squamous cell carcinoma in situ arising in mature cystic teratoma of the ovary: a case report

Cited by 10 publications

References 6 publications

Relevance of frozen sections and serum markers in invasive squamous cell carcinoma arising from ovarian mature cystic teratoma: two case reports

Relevance of frozen sections and serum markers in invasive squamous cell carcinoma arising from ovarian mature cystic teratoma: two case reports

Appendix and Uterus Metastasis of Squamous Cell Carcinoma Arising from Mature Cystic Teratoma of the Ovary

Squamous cell carcinoma in mature cystic teratoma of the ovary

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