Squamous Cell Carcinoma in an Inverted Papilloma of the Buccal Mucosa

Abstract

Inverted papillomas of the oral cavity are rare lesions. Although in the seven oral cases previously reported the lesions were benign, approximately 10% to 15% of inverted papillomas of the nasal cavity and paranasal sinuses develop or are associated with squamous cell carcinoma. This report presents a case of squamous cell carcinoma arising in an inverted papilloma of the buccal mucosa. Histologically, this lesion demonstrated the morphologic features of inverted papilloma in the superficial portion, and squamous carcinoma in deeper sections. This case suggests that although rare, inverted papillomas of the oral cavity should be considered potentially malignant or capable of harboring a malignancy.

Inverted ductal papilloma of the oral cavity secondary to lower lip trauma. A case report and literature review.

“…The patient age at appearance of the lesion is usually between the fourth and fifth decade of life and no particular gender predilection has been observed (1,5). In our review of the literature, the mean age was found to be 44 years, with a range of 27-65 years.…”

“…The postoperative course in our patient was free of complications, and she is presently subjected to periodic controls to detect possible relapse. No relapses or malignization of IDPOC have been documented though a squamous cell carcinoma in an IP of the cheek mucosa has been identified (1). In most cases these complications are a consequence of an incomplete resection of the lesion.…”

“…It normally shows exophytic growth with a poly-poid or verrucous appearance. However, there have been reports of cases characterized by endophytic or inverted growth (1), most often located in the nasal and paranasal sinus mucosa, in the bladder, and in the lacrimal gland (2). Some papillary lesions of the secretory duct of a salivary gland, such as oncocytoma, papillary cystoadenoma, Warthin’s tumor, intraductal papilloma (IP), inverted ductal papilloma and sialoadenoma papilliferum can clinically manifest as tumors of the oral cavity (3).…”

Schneiderian Papillomas of the Pharynx

“…The ectopic occurrence of schneiderian papillomas -that is, outside the sinonasal tract -has been reported in 15 patients. Three of these cases occurred in the nasopharynx, 7-9 2 in cervical lymph nodes, 10 -1 ' 1 in the oropharynx, 12 1 in the oral cavity, 13 1 in the hypopharynx, 14 and 7 in the middle ear and mastoid. 15 " 18 Five of the lesions of the middle ear and mastoid originated from the Otolaryngic Tumor Registry of the Armed Forces Institute of Pathology.…”