Schneiderian Papillomas of the Pharynx

Abstract

Sixteen cases of schneiderian-type mucosal papillomas arising in the nasopharynx and oropharynx are reported. The patients include 11 men and 5 women ranging in age from 45 to 79 years (median 62 years). In 12 patients, the papilloma was discovered as an incidental finding, and 2 patients complained of nasal airway obstruction. In the remaining 2 cases, information regarding the cause that led to discovery was unavailable. None of the patients had a prior or concurrent history of sinonasal (schneiderian) papillomas. Histologically, all of the tumors were identical to sinonasal inverted papillomas. Transnasal or transoral surgical excision was the treatment of choice. In 4 of the patients, recurrent tumor occurred within 6 months of initial resection, necessitating additional surgery. Extended follow-up information was available in 9 cases. Eight of the 9 patients are alive and have been free of disease over periods ranging from 15 to 201 months (median 114 months) from diagnosis. One patient was found to have a separate nasopharyngeal squamous cell carcinoma 14 months after the diagnosis of the schneiderian-type papilloma. This patient died secondary to the squamous cell carcinoma 30 months after his initial evaluation.

Biphasic Low-Grade Nasopharyngeal Papillary Adenocarcinoma with a Prominent Spindle Cell Component: Report of a Case Localized to the Posterior Nasal Septum

“…In this context it should be mentioned that it has been claimed that the papillary variant of PLGA shows a more aggressive behaviour than the nonpapillary variants [30,41]. Schneiderian papillomas (SP) may be seen in the nasopharynx [42,43]. SP occurring in this site display the same histological features (non-keratinizing squamous-, ''transitional-type''-, and pseudostratified epithelium with oncocytoid characteristics), as seen in the sinonasal area and which differ from the hyalinized fibrovascular cores lined by the bland cuboidal to columnar cells in LGPACNP.…”

Schneiderian Papillomas and Nonsalivary Glandular Neoplasms of the Head and Neck

“…They have been recorded in middle ear-mastoid (34), pharynx (35,36), nasopharynx (37), lacrimal sac (38), and possibly in the wall of a branchial cleft cyst (39). It has been suggested that ectopic migration of the Schneiderian membrane during embryogenesis could account for these aberrant papillomas in sites contiguous with the sinonasal tract (2).…”

Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor (VEGF) expression in Sinonasal Inverted Papillomas

“…It amounts, according to different studies, between 5.7-32%[25]. On the other side, the correlation among inverted papilloma and squamous cell carcinomas is well documented.Current literature shows this correlation somewhere between 10-25 %[13][14][15][16].…”