Squamous Cell Carcinoma in a Heel Ulcer in a Patient With Diabetes

Kong, Marie‐France; Jogia, Rajesh; Nayyar, Vidhu; Berrington, Rachel; Jackson, Shawn S.

doi:10.2337/dc08-0284

Cited by 12 publications

(18 citation statements)

References 6 publications

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“…In the current study, the risk was remarkably high, SIR over 5 times in men and women and 9.40 in women, which is in accordance with our previous results showing that skin cancer risks increased after autoimmune diseases [12,27]. As reported, chronic skin inflammation or immunosuppression by medication may promote development of squamous cell skin carcinoma [24]. Patients with T2DM often develop skin infections, whereas those with T1DM are prone to have autoimmune-related lesions, including periungual telangiectasia, necrobiosis lipoidica, bullosis diabeticorum, vitiligo and lichen rubber planus, all of which increase the skin cancer risk [26].…”

Section: Discussionsupporting

confidence: 93%

“…Skin cancer (squamous cell carcinoma) has been reported to be increased in patients with T2DM [24–26], but not after T1DM even in the previous population‐based Swedish study [8]. In the current study, the risk was remarkably high, SIR over 5 times in men and women and 9.40 in women, which is in accordance with our previous results showing that skin cancer risks increased after autoimmune diseases [12,27].…”

Section: Discussionsupporting

confidence: 91%

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Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population‐based cohort study in Sweden

Shu

et al. 2010

Diabetic Medicine

102

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 91%

Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population‐based cohort study in Sweden

Shu

et al. 2010

Diabetic Medicine

102

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“…In conclusion, our case report corroborates and expands previous observations ( 7 , 8 , 9 ), reinforcing the notion that cSCC may be a serious (albeit rare) complication of the diabetic foot in elderly T2DM patients. The diagnosis of cSCC should always be considered and ruled out in a chronic non-healing lesion, especially in consideration of the latest risk factors for the development and progression of cSCC, in order to prevent a procrastination in the diagnosis and treatment and to improve outcome.…”

Section: Discussionsupporting

confidence: 92%

“…To date, in the literature, cSCC developing in association with a diabetic foot ulcer has been already described in some reports ( 7 , 8 , 9 ), but more information is required in order to make the clinicians aware of this rare (albeit possible) complication.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complication

Mantovani

Teobaldi

Stoico

et al. 2018

Endocrinology, Diabetes &Amp; Metabolism Case Reports

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SummaryAfter basal cell carcinoma, the cutaneous squamous cell carcinoma (cSCC) is the second most frequent non-melanoma skin cancer worldwide, and, classically, arises from the upper coats of the epidermis of sun-exposed areas or from skin areas constantly exposed to a chronic inflammatory stimulus. The occurrence of cSCC seems to be linked to several factors, including exposure to sunlight (or other ultraviolet radiations), immunosuppression, chronic scarring conditions and some familial cancer syndromes. Although the majority of cSCCs are adequately eradicated by surgical excision, a subgroup of cSCC may be linked with an increased risk of recurrence, metastasis and death. The incidence of type 2 diabetes mellitus is constantly increasing worldwide. Importantly, diabetes mellitus is a strong risk factor for cancers (including cutaneous tumors) and is highly related with poor cancer outcomes. At present, in the literature, squamous cell carcinoma developing in association with diabetic foot ulcers has been already reported in some reports; however, additional data are needed to make the clinicians aware of this rare, although possible, complication. Therefore, we herein report an unusual case of an elderly man with T2DM and a positive oncological history, presenting a cSCC involving the skin overlying the first toe of left foot. The growing cSCC appeared approximately 3 years after the appearance of a diabetic ulcer.Learning points:Diabetic foot ulcers are an important and severe complication of diabetes mellitus and often can result in foot amputation.Chronic and non-healing diabetic foot ulcers are often observed in clinical practice.Clinicians should always take into consideration the malignant degeneration (e.g., cutaneous squamous cell carcinoma) of any chronic non-healing diabetic foot ulcer in elderly T2DM individuals.Timely surgical resection of a chronic, non-healing diabetic foot ulcer might preclude the development of a cutaneous squamous cell carcinoma.

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“…There is emerging evidence from non-randomised controlled trials (non-RCTs) that feedback and benchmarking exert a positive effect on process, outcome and overall provision of diabetes care [28-31]. However, follow up over time without specific interventions has also demonstrated improvements in diabetes care [32,33].…”

Section: Discussionmentioning

confidence: 99%

Study rationale and design of OPTIMISE, a randomised controlled trial on the effect of benchmarking on quality of care in type 2 diabetes mellitus

Nobels

Debacker²,

Brotons

et al. 2011

Cardiovasc Diabetol

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BackgroundTo investigate the effect of physician- and patient-specific feedback with benchmarking on the quality of care in adults with type 2 diabetes mellitus (T2DM).MethodsStudy centres in six European countries were randomised to either a benchmarking or control group. Physicians in both groups received feedback on modifiable outcome indicators (glycated haemoglobin [HbA1c], glycaemia, total cholesterol, high density lipoprotein-cholesterol, low density lipoprotein [LDL]-cholesterol and triglycerides) for each patient at 0, 4, 8 and 12 months, based on the four times yearly control visits recommended by international guidelines. The benchmarking group also received comparative results on three critical quality indicators of vascular risk (HbA1c, LDL-cholesterol and systolic blood pressure [SBP]), checked against the results of their colleagues from the same country, and versus pre-set targets. After 12 months of follow up, the percentage of patients achieving the pre-determined targets for the three critical quality indicators will be assessed in the two groups.ResultsRecruitment was completed in December 2008 with 3994 evaluable patients.ConclusionsThis paper discusses the study rationale and design of OPTIMISE, a randomised controlled study, that will help assess whether benchmarking is a useful clinical tool for improving outcomes in T2DM in primary care.Trial registrationNCT00681850

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Squamous Cell Carcinoma in a Heel Ulcer in a Patient With Diabetes

Cited by 12 publications

References 6 publications

Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population‐based cohort study in Sweden

Cancer risk among patients hospitalized for Type 1 diabetes mellitus: a population‐based cohort study in Sweden

Cutaneous squamous carcinoma in a patient with diabetic foot: an unusual evolution of a frequent complication

Study rationale and design of OPTIMISE, a randomised controlled trial on the effect of benchmarking on quality of care in type 2 diabetes mellitus

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