Squamous cell carcinoma in a child with xeroderma pigmentosum: Clinical response with photon beam radiation therapy and review of literature

Abdullahi, Adamu; Muhammad, Yusuf Shehu; Ayodeji, Olasinde Tajudeen; Ayorinde, Dawotola David

doi:10.4103/2384-5147.172452

Cited by 3 publications

(3 citation statements)

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“…SCC is the most reported type of malignancy affecting the oral mucosa in patients with XP (Figure 4a,b). 17,19–48 In fact, 93 mucosal SCCs have been reported in 130 pediatric XP patients. The most common sites were the tongue (43/93, 46.2%) and lips (34/93, 36.6%).…”

Section: Resultsmentioning

confidence: 99%

“…Specifically, one limbal SCC and one pigmented mass in limbus, 29,47 two melanomas on medial canthus 21 and conjunctiva, 22 and multiple SCCs on the conjunctiva 17,42,46,76 have been reported in pediatric XP patients. The majority of XP patients with oral mucosal lesions included in this review (110/130, 84.6%) also exhibited ocular findings, such as keratitis, blindness, and symblepharon 17–19,21–24,29–31,40,41,43,45–48,67 . It is worth noting that our literature review focused exclusively on oral mucosal findings in pediatric patients and did not include a specific search for other mucosal areas, such as the genital mucosa or ocular areas.…”

Section: Resultsmentioning

confidence: 99%

“…The majority of XP patients with oral mucosal lesions included in this review (110/ 130, 84.6%) also exhibited ocular findings, such as keratitis, blindness, and symblepharon. [17][18][19][21][22][23][24][29][30][31]40,41,43,[45][46][47][48]67 It is worth noting that our literature review focused exclusively on oral mucosal findings in pediatric patients and did not include a specific search for other mucosal areas, such as the genital mucosa or ocular areas.…”

Section: Non-tumoral Lesionsmentioning

confidence: 99%

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Oral mucosa involvement in pediatric patients with xeroderma pigmentosum: a comprehensive review

Baskurt,

Vural,

Ertekin

et al. 2023

Int J Dermatology

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BackgroundXeroderma pigmentosum (XP) is a rare autosomal recessive disorder presenting with an inability to repair UV‐induced DNA damage. This can lead to the development of neoplasms affecting multiple organ systems, with onset often in childhood. Unfortunately, no cure currently exists for XP, and management strategies focus on sun protection and early intervention for malignancies. Although most skin problems in XP patients are UV induced, various oral lesions are also described. However, the literature has not extensively characterized the oral manifestations and their prognostic significance.MethodsWe conducted a comprehensive review to evaluate the prevalence and nature of oral mucosal lesions in pediatric XP patients.ResultsOur literature search yielded 130 pediatric XP patients with oral involvement and 210 associated tumoral or non‐tumoral lesions. Squamous cell carcinoma was the most common type of oral mucosal tumor reported, with other malignancies including basal cell carcinoma, melanoma, angiosarcoma, fibrosarcoma, and trichilemmal carcinoma.ConclusionGiven the potential morbidity and mortality associated with oral mucosal tumors in XP patients, our study aims to raise awareness of these manifestations. Early diagnosis and treatment are crucial for managing these lesions effectively, and routine oral exams should be considered a critical component of dermatological evaluations for XP patients, especially in the pediatric age group.

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Section: Resultsmentioning

confidence: 99%