Unusual intraoral cancer with unexpected outcome in a patient with xeroderma pigmentosum: An alert for antineoplastic treatment

Severe cisplatin-induced renal toxicity in a patient with xeroderma pigmentosum

“…13,15 Depending on the degree of XP-C inactivity and the damage caused to normal cells, cisplatin can be fatal, especially as a result of renal failure as the kidneys are the principle route of drug elimination. 6,13 Due to the lack of evidence supporting the use of cisplatin in cutaneous SCC and the concerns related to efficacy and toxicity in patients with XP, other treatment options should be explored. A patient with XP and a skin SCC was initially treated with cisplatin and infusional fluorouracil.…”

“…13 In patients with XP, who are potential carriers of defective XP-C, this mechanism, designed to reverse the damage caused by cisplatin chemotherapy in normal cells, can be compromised, resulting in normal cells also undergoing apoptosis. 13,15 Depending on the degree of XP-C inactivity and the damage caused to normal cells, cisplatin can be fatal, especially as a result of renal failure as the kidneys are the principle route of drug elimination. 6,13 Due to the lack of evidence supporting the use of cisplatin in cutaneous SCC and the concerns related to efficacy and toxicity in patients with XP, other treatment options should be explored.…”

“…A 23-year-old woman with a previous history of XP was diagnosed with SCC of the floor of the mouth. 13 The malignant lesion was excised, and the patient commenced chemoradiation with cisplatin (50 mg dose). She presented to the emergency department 2 days later following severe diarrhoea, nausea, and vomiting.…”

“…14 XP complementation group C (XP-C) is an important protein in the altered DNA repair process, mainly because it plays a role in the recognition and repair of damage. 13 In patients with XP, who are potential carriers of defective XP-C, this mechanism, designed to reverse the damage caused by cisplatin chemotherapy in normal cells, can be compromised, resulting in normal cells also undergoing apoptosis. 13,15 Depending on the degree of XP-C inactivity and the damage caused to normal cells, cisplatin can be fatal, especially as a result of renal failure as the kidneys are the principle route of drug elimination.…”

“…13,15 Depending on the degree of XP-C inactivity and the damage caused to normal cells, cisplatin can be fatal, especially as a result of renal failure as the kidneys are the principle route of drug elimination. 6,13…”