Squamous cell carcinoma at an ileostomy site—Fifty-four years following colectomy for ulcerative colitis: A case report and literature review

Abstract

Patients with chronic stomal inflammation, bleeding or persistent induration and/or mass formation should be followed up closely and investigated for recurrence or development of a new malignancy. There should be a low threshold to obtain an early definitive tissue diagnosis by taking biopsies to prevent local or systemic invasion.

Stoma Complications: Corticosteroid and Silver Nitrate-Resistant Inflammation Successfully Treated with Topical Tacrolimus

“…A patch test excluded a contact dermatitis to any of the components of the stoma pouch material or to other related accessories and cleansing products. Even if carcinoma arising at an ileostomy is a rare occurrence [1] , we performed biopsies on the glandular mucosa on the external side of the stoma, which confirmed the absence of any dysplastic change or malignancy. Histology confirmed the presence of florid inflammation and ulceration with fibrino-purulent slough, in keeping with severe ileitis also with ulcerative changes ( Fig.…”

Primary squamous cell carcinoma at ileostomy site. Two case reports and review of literature

“…Primary squamous cell carcinoma at the ileostomy site is an extremely rare tumor. Literature search including PubMed, Google, and Medline, yielded only 6 reported cases prior to our report 1 …”

“…They found only three cases reported, including the one they presented. Since then, Farshid and colleagues published a case report and another literature review in which they reported a total of 6 cases of SCC at the ileostomy site 1 …”

“…The available literature suggests that SCC is a late complication that is usually seen many years after creation of a permanent ileostomy. The earliest presentation was 26 years after ileostomy creation 1,2 …”

“…The main etiology is believed to be chronic irritation 1,4‐7 secondary to toxins in the stool and/or urine, or recurrent skin infections over the years. Both situations could cause a localized chronic response leading to metaplasia that could subsequently progress to carcinoma 1,8 …”